Lipid nanoparticle siRNA systems for silencing the androgen receptor in human prostate cancer in vivo

International Journal of Cancer

Volumn 131, Issue 5, 2012, Pages

  Lee, Justin B ^a   Zhang, Kaixin ^b   Tam, Yuen Yi C ^a   Tam, Ying K ^a   Belliveau, Nathan M ^a   Sung, Vanessa Y C ^a   Lin, Paulo J C ^a   LeBlanc, Eric ^b   Ciufolini, Marco A ^a   Rennie, Paul S ^b   Cullis, Pieter R ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b VANCOUVER PROSTATE CENTRE   (Canada)

Author keywords

Androgen receptor; Lipid nanoparticles; Liposomes; Prostate cancer; siRNA

Indexed keywords

1,3 DIOXOLANE DERIVATIVE; 2,2 DILINOLEYL 4 (2 DIMETHYLAMINOETHYL) [1,3] DIOXOLANE; ANDROGEN RECEPTOR; NANOPARTICLE; PROSTATE SPECIFIC ANTIGEN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG POTENCY; DRUG RELEASE; FEASIBILITY STUDY; GENE EXPRESSION REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; NANOPHARMACEUTICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROSTATE CANCER; RECEPTOR GENE; TUMOR XENOGRAFT; UPREGULATION; WILD TYPE;

ANDROGEN RECEPTOR ANTAGONISTS; DISEASE PROGRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIPIDS; MALE; NANOPARTICLES; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; RNA, SMALL INTERFERING; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84863201108     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.27361     Document Type: Article

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