Toward synthetic viruses: Endosomal pH-Triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo

Molecular Therapy

Volumn 11, Issue 3, 2005, Pages 418-425

  Walker, Greg F ^a   Fella, Carolin ^a   Pelisek, Jaroslav ^a   Fahrmeir, Julia ^a   Boeckle, Sabine ^a   Ogris, Manfred ^a   Wagner, Ernst ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Bioreversible; PEG shielding; Polyethylenimine; Subcutaneous tumors; Systemic gene targeting

Indexed keywords

DNA; EPIDERMAL GROWTH FACTOR; HYDRAZIDE DERIVATIVE; HYDRAZINE DERIVATIVE; HYDRAZONE DERIVATIVE; LIGAND; MACROGOL; POLYLYSINE; PROPIONALDEHYDE; TRANSFERRIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOSOME; FEMALE; GENE EXPRESSION; GENE TARGETING; GENE TRANSFER; GENE VECTOR; GENETIC TRANSFECTION; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PH;

ANIMALS; DNA; ENDOSOMES; GENE TRANSFER TECHNIQUES; HUMANS; HYDROGEN-ION CONCENTRATION; K562 CELLS; MICE; POLYAMINES; POLYETHYLENE GLYCOLS; TIME FACTORS;

EID: 14044252938     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2004.11.006     Document Type: Article

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