MMP-9 gene silencing by a quantum dot-siRNA nanoplex delivery to maintain the integrity of the blood brain barrier

Brain Research

Volumn 1282, Issue , 2009, Pages 142-155

  Bonoiu, Adela ^a   Mahajan, Supriya D ^b   Ye, Ling ^a   Kumar, Rajiv ^a   Ding, Hong ^a   Yong, Ken Tye ^a   Roy, Indrajit ^a   Aalinkeel, Ravikumar ^b   Nair, Bindukumar ^b   Reynolds, Jessica L ^b   Sykes, Donald E ^b   Imperiale, Marco A ^b   Bergey, Earl J ^a   Schwartz, Stanley A ^b   Prasad, Paras N ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

Blood brain barrier; CNS; Matrix metalloproteinases; MMP 9; Nanoplex; Nanotechnology; Quantum dot; siRNA

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 4; COLLAGEN TYPE 5; GELATINASE B; NANOPARTICLE; POLYDIALLYLDIMETHYLAMMONIUM CHLORIDE; QUANTUM DOT; SCLEROPROTEIN; SMALL INTERFERING RNA; TISSUE INHIBITOR OF METALLOPROTEINASE 1; UNCLASSIFIED DRUG;

ARTICLE; BASEMENT MEMBRANE; BLOOD BRAIN BARRIER; BRAIN CELL; CELL INVASION; CELL MEMBRANE PERMEABILITY; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DOWN REGULATION; ENCEPHALITIS; ENDOTHELIUM CELL; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATORY CELL; LEUKOCYTE; MICROVASCULATURE; NEUROMODULATION; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; UPREGULATION;

BASEMENT MEMBRANE; BLOOD-BRAIN BARRIER; CELLS, CULTURED; DOWN-REGULATION; ENCEPHALITIS; ENDOTHELIAL CELLS; EXTRACELLULAR MATRIX PROTEINS; GENE TRANSFER TECHNIQUES; HUMANS; MATRIX METALLOPROTEINASE 9; NANOPARTICLES; QUANTUM DOTS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 67649948599     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2009.05.047     Document Type: Article

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