-
1
-
-
0026042170
-
Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import
-
Adam, S.A. and Gerace, L. 1991. Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import. Cell 66: 837-847.
-
(1991)
Cell
, vol.66
, pp. 837-847
-
-
Adam, S.A.1
Gerace, L.2
-
2
-
-
0842324801
-
The mechanisms of vesicle budding and fusion
-
Bonifacino, J.S. and Glick, B.S. 2004. The mechanisms of vesicle budding and fusion. Cell 116: 153-166.
-
(2004)
Cell
, vol.116
, pp. 153-166
-
-
Bonifacino, J.S.1
Glick, B.S.2
-
3
-
-
0027159260
-
TGN38 is maintained in the trans-Golgi network by a tyrosine-containing motif in the cytoplasmic domain
-
Bos, K., Wraight, C., and Stanley, K.K. 1993. TGN38 is maintained in the trans-Golgi network by a tyrosine-containing motif in the cytoplasmic domain. EMBO J. 12: 2219-2228.
-
(1993)
EMBO J
, vol.12
, pp. 2219-2228
-
-
Bos, K.1
Wraight, C.2
Stanley, K.K.3
-
4
-
-
33751099034
-
RNAi therapeutics: A potential new class of pharmaceutical drugs. Nat
-
Bumcrot, D., Manoharan, M., Koteliansky, V., and Sah, D.W. 2006. RNAi therapeutics: A potential new class of pharmaceutical drugs. Nat Chem. Biol. 2: 711-719.
-
(2006)
Chem. Biol
, vol.2
, pp. 711-719
-
-
Bumcrot, D.1
Manoharan, M.2
Koteliansky, V.3
Sah, D.W.4
-
5
-
-
33645891179
-
Enhanced hepatic uptake and bioactivity of type α 1(I) collagen gene promoter- specific triplex-forming oligonucleotides after conjugation with cholesterol
-
Cheng, K., Ye, Z., Guntaka, R.V., and Mahato, R.I. 2006. Enhanced hepatic uptake and bioactivity of type α 1(I) collagen gene promoter- specific triplex-forming oligonucleotides after conjugation with cholesterol. J. Pharmacol Exp. Ther. 317: 797-805.
-
(2006)
J. Pharmacol Exp. Ther
, vol.317
, pp. 797-805
-
-
Cheng, K.1
Ye, Z.2
Guntaka, R.V.3
Mahato, R.I.4
-
6
-
-
34447559636
-
Interfering with disease: A progress report on siRNA-based therapeutics
-
de Fougerolles, A., Vornlocher, H.P., Maraganore, J., and Lieberman, J. 2007. Interfering with disease: A progress report on siRNA-based therapeutics. Nat. Rev. Drug Discov. 6: 443-453.
-
(2007)
Nat. Rev. Drug Discov
, vol.6
, pp. 443-453
-
-
de Fougerolles, A.1
Vornlocher, H.P.2
Maraganore, J.3
Lieberman, J.4
-
7
-
-
38949184554
-
Delivery of proteins and nucleic acids using a noncovalent peptide-based strategy
-
Deshayes, S., Morris, M., Hertz, F., and Divita, G. 2008. Delivery of proteins and nucleic acids using a noncovalent peptide-based strategy. Adv. Drug Deliv. Rev. 60: 537-547.
-
(2008)
Adv. Drug Deliv. Rev
, vol.60
, pp. 537-547
-
-
Deshayes, S.1
Morris, M.2
Hertz, F.3
Divita, G.4
-
8
-
-
0021100690
-
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
-
Dignam, J.D., Lebovitz, R.M., and Roeder, R.G. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11: 1475-1489.
-
(1983)
Nucleic Acids Res
, vol.11
, pp. 1475-1489
-
-
Dignam, J.D.1
Lebovitz, R.M.2
Roeder, R.G.3
-
9
-
-
3242677639
-
siRNAs: Applications in functional genomics and potential as therapeutics
-
Dorsett, Y. and Tuschl, T. 2004. siRNAs: Applications in functional genomics and potential as therapeutics. Nat. Rev. Drug Discov. 3: 318-329.
-
(2004)
Nat. Rev. Drug Discov
, vol.3
, pp. 318-329
-
-
Dorsett, Y.1
Tuschl, T.2
-
10
-
-
0035803583
-
Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate
-
Elbashir, S.M., Martinez, J., Patkaniowska, A., Lendeckel, W., and Tuschl, T. 2001. Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J. 20: 6877-6888.
-
(2001)
EMBO J
, vol.20
, pp. 6877-6888
-
-
Elbashir, S.M.1
Martinez, J.2
Patkaniowska, A.3
Lendeckel, W.4
Tuschl, T.5
-
11
-
-
0036351317
-
Analysis of gene function in somatic mammalian cells using small interfering RNAs
-
Elbashir, S.M., Harborth, J., Weber, K., and Tuschl, T. 2002. Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods 26: 199-213.
-
(2002)
Methods
, vol.26
, pp. 199-213
-
-
Elbashir, S.M.1
Harborth, J.2
Weber, K.3
Tuschl, T.4
-
12
-
-
0033922714
-
Penetration of protein toxins into cells
-
Falnes, P.O. and Sandvig, K. 2000. Penetration of protein toxins into cells. Curr. Opin. Cell Biol. 12: 407-413.
-
(2000)
Curr. Opin. Cell Biol
, vol.12
, pp. 407-413
-
-
Falnes, P.O.1
Sandvig, K.2
-
13
-
-
2942530436
-
Inhibition of influenza virus production in virus-infected mice by RNA interference
-
Ge, Q., Filip, L., Bai, A., Nguyen, T., Eisen, H.N., and Chen, J. 2004. Inhibition of influenza virus production in virus-infected mice by RNA interference. Proc. Natl. Acad. Sci. 101: 8676-8681.
-
(2004)
Proc. Natl. Acad. Sci
, vol.101
, pp. 8676-8681
-
-
Ge, Q.1
Filip, L.2
Bai, A.3
Nguyen, T.4
Eisen, H.N.5
Chen, J.6
-
14
-
-
33746267422
-
RNA interference-mediated gene silencing of pleiotrophin through polyethylenimine-complexed small interfering RNAs in vivo exerts antitumoral effects in glioblastoma xenografts
-
Grzelinski, M., Urban-Klein, B., Martens, T., Lamszus, K., Bakowsky, U., Hobel, S., Czubayko, F., and Aigner, A. 2006. RNA interference-mediated gene silencing of pleiotrophin through polyethylenimine-complexed small interfering RNAs in vivo exerts antitumoral effects in glioblastoma xenografts. Hum. Gene Ther. 17: 751-766.
-
(2006)
Hum. Gene Ther
, vol.17
, pp. 751-766
-
-
Grzelinski, M.1
Urban-Klein, B.2
Martens, T.3
Lamszus, K.4
Bakowsky, U.5
Hobel, S.6
Czubayko, F.7
Aigner, A.8
-
15
-
-
36749022303
-
Expanding the repertoire of RNA interference screens for developing new anticancer drug targets
-
Haney, S.A. 2007. Expanding the repertoire of RNA interference screens for developing new anticancer drug targets. Expert Opin. Ther. Targets 11: 1429-1441.
-
(2007)
Expert Opin. Ther. Targets
, vol.11
, pp. 1429-1441
-
-
Haney, S.A.1
-
16
-
-
0037062951
-
RNA interference
-
Hannon, G.J. 2002. RNA interference. Nature 418: 244-251.
-
(2002)
Nature
, vol.418
, pp. 244-251
-
-
Hannon, G.J.1
-
17
-
-
0027395956
-
Localization of TGN38 to the trans-Golgi network: Involvement of a cytoplasmic tyrosine-containing sequence
-
Humphrey, J.S., Peters, P.J., Yuan, L.C., and Bonifacino, J.S. 1993. Localization of TGN38 to the trans-Golgi network: Involvement of a cytoplasmic tyrosine-containing sequence.J. CellBiol 120:1123-1135.
-
(1993)
J. CellBiol
, vol.120
, pp. 1123-1135
-
-
Humphrey, J.S.1
Peters, P.J.2
Yuan, L.C.3
Bonifacino, J.S.4
-
18
-
-
0042161890
-
The activity of siRNA in mammalian cells is related to structural target accessibility: A comparison with antisense oligonucleotides
-
Kretschmer-Kazemi Far, R. and Sczakiel, G. 2003. The activity of siRNA in mammalian cells is related to structural target accessibility: A comparison with antisense oligonucleotides. Nucleic Acids Res. 31: 4417-4424.
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 4417-4424
-
-
Kretschmer-Kazemi Far, R.1
Sczakiel, G.2
-
19
-
-
0037444495
-
Distinct caveolae-mediated endocytic pathways target the Golgi apparatus and the endoplasmic reticulum
-
Le, P.U. and Nabi, I.R. 2003. Distinct caveolae-mediated endocytic pathways target the Golgi apparatus and the endoplasmic reticulum.J. Cell Sci. 116: 1059-1071.
-
(2003)
J. Cell Sci
, vol.116
, pp. 1059-1071
-
-
Le, P.U.1
Nabi, I.R.2
-
20
-
-
38949206876
-
Cell penetrating peptide conjugates of steric block oligonucleotides
-
Lebleu, B., Moulton, H.M., Abes, R., Ivanova, G.D., Abes, S., Stein, D.A., Iversen, P.L., Arzumanov, A.A., and Gait, M.J. 2008. Cell penetrating peptide conjugates of steric block oligonucleotides. Adv. Drug Deliv. Rev. 60: 517-529.
-
(2008)
Adv. Drug Deliv. Rev
, vol.60
, pp. 517-529
-
-
Lebleu, B.1
Moulton, H.M.2
Abes, R.3
Ivanova, G.D.4
Abes, S.5
Stein, D.A.6
Iversen, P.L.7
Arzumanov, A.A.8
Gait, M.J.9
-
21
-
-
0037031576
-
Single-stranded antisense siRNAs guide target RNA cleavage in RNAi
-
Martinez, J., Patkaniowska, A., Urlaub, H., Luhrmann, R., and Tuschl, T. 2002. Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell 110: 563-574.
-
(2002)
Cell
, vol.110
, pp. 563-574
-
-
Martinez, J.1
Patkaniowska, A.2
Urlaub, H.3
Luhrmann, R.4
Tuschl, T.5
-
22
-
-
1242318826
-
Sequence-specific inhibition of microRNA-and siRNA-induced RNA silencing
-
Meister, G., Landthaler, M., Dorsett, Y., and Tuschl, T. 2004. Sequence-specific inhibition of microRNA-and siRNA-induced RNA silencing. RNA 10: 544-550.
-
(2004)
RNA
, vol.10
, pp. 544-550
-
-
Meister, G.1
Landthaler, M.2
Dorsett, Y.3
Tuschl, T.4
-
23
-
-
35348861314
-
Cellular uptake and intracellular release are major obstacles to the therapeutic application of siRNA: Novel options by phosphorothioate- stimulated delivery
-
Mescalchin, A., Detzer, A., Wecke, M., Overhoff, M., Wiinsche, W., and Sczakiel, G. 2007. Cellular uptake and intracellular release are major obstacles to the therapeutic application of siRNA: Novel options by phosphorothioate- stimulated delivery. Expert Opin. Biol. Ther. 7: 1531-1538.
-
(2007)
Expert Opin. Biol. Ther
, vol.7
, pp. 1531-1538
-
-
Mescalchin, A.1
Detzer, A.2
Wecke, M.3
Overhoff, M.4
Wiinsche, W.5
Sczakiel, G.6
-
24
-
-
3242733298
-
Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo
-
doi: 10.1093/nar/gnh093
-
Minakuchi, Y., Takeshita, F., Kosaka, N., Sasaki, H., Yamamoto, Y., Kouno, M., Honma, K., Nagahara, S., Hanai, K., Sano, A., et al. 2004. Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo. Nucleic Acids Res. 32: el09. doi: 10.1093/nar/gnh093.
-
(2004)
Nucleic Acids Res
, vol.32
-
-
Minakuchi, Y.1
Takeshita, F.2
Kosaka, N.3
Sasaki, H.4
Yamamoto, Y.5
Kouno, M.6
Honma, K.7
Nagahara, S.8
Hanai, K.9
Sano, A.10
-
25
-
-
23444445660
-
Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs
-
Morrissey, D.V., Lockridge, J.A., Shaw, L., Blanchard, K., Jensen, K., Breen, W., Hartsough, K., Machemer, L., Radka, S., Jadhav, V., et al. 2005. Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. Nat. Biotechnol. 23: 1002-1007.
-
(2005)
Nat. Biotechnol
, vol.23
, pp. 1002-1007
-
-
Morrissey, D.V.1
Lockridge, J.A.2
Shaw, L.3
Blanchard, K.4
Jensen, K.5
Breen, W.6
Hartsough, K.7
Machemer, L.8
Radka, S.9
Jadhav, V.10
-
26
-
-
0023652396
-
A C-terminal signal prevents secretion of luminal ER proteins
-
Munro, S. and Pelham, H.R. 1987. A C-terminal signal prevents secretion of luminal ER proteins. Cell 48: 899-907.
-
(1987)
Cell
, vol.48
, pp. 899-907
-
-
Munro, S.1
Pelham, H.R.2
-
27
-
-
0036636074
-
Nucleic-acid therapeutics: Basic principles and recent applications
-
Opalinska, J.B. and Gewirtz, A.M. 2002. Nucleic-acid therapeutics: Basic principles and recent applications. Nat. Rev. Drug Discov. 1: 503-514.
-
(2002)
Nat. Rev. Drug Discov
, vol.1
, pp. 503-514
-
-
Opalinska, J.B.1
Gewirtz, A.M.2
-
28
-
-
28544444484
-
Phosphorothioate-stimulated uptake of short interfering RNA by human cells
-
Overhoff, M. and Sczakiel, G. 2005. Phosphorothioate-stimulated uptake of short interfering RNA by human cells. EMBO Rep. 6: 1176-1181.
-
(2005)
EMBO Rep
, vol.6
, pp. 1176-1181
-
-
Overhoff, M.1
Sczakiel, G.2
-
29
-
-
85047173190
-
Quantitative detection of siRNA and single-stranded oligonucleotides: Relationship between uptake and biological activity of siRNA
-
doi: 10.1093/nar/gnhl68
-
Overhoff, M., Wünsche, W., and Sczakiel, G. 2004. Quantitative detection of siRNA and single-stranded oligonucleotides: relationship between uptake and biological activity of siRNA. Nucleic Acids Res. 32: el70. doi: 10.1093/nar/gnhl68.
-
(2004)
Nucleic Acids Res
, vol.32
-
-
Overhoff, M.1
Wünsche, W.2
Sczakiel, G.3
-
30
-
-
33845755467
-
Illuminating the silence: Understanding the structure and function of small RNAs
-
Rana, T.M. 2007. Illuminating the silence: Understanding the structure and function of small RNAs. Nat. Rev. Mol. Cell Biol. 8: 23-36.
-
(2007)
Nat. Rev. Mol. Cell Biol
, vol.8
, pp. 23-36
-
-
Rana, T.M.1
-
31
-
-
27344460405
-
A conserved motif in transmembrane helix 1 of diphtheria toxin mediates catalytic domain delivery to the cytosol
-
Ratts, R., Trujillo, C., Bharti, A., vanderSpek, J., Harrison, R., and Murphy, J.R 2005. A conserved motif in transmembrane helix 1 of diphtheria toxin mediates catalytic domain delivery to the cytosol. Proc. Natl. Acad. Sci. 102: 15635-15640.
-
(2005)
Proc. Natl. Acad. Sci
, vol.102
, pp. 15635-15640
-
-
Ratts, R.1
Trujillo, C.2
Bharti, A.3
vanderSpek, J.4
Harrison, R.5
Murphy, J.R.6
-
32
-
-
33746883220
-
A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium
-
Santel, A., Aleku, M., Keil, O., Endruschat, J., Esche, V., Fisch, G., Dames, S., Loffler, K., Fechtner, M., Arnold, W., et al. 2006. A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium. Gene Ther. 13: 1222-1234.
-
(2006)
Gene Ther
, vol.13
, pp. 1222-1234
-
-
Santel, A.1
Aleku, M.2
Keil, O.3
Endruschat, J.4
Esche, V.5
Fisch, G.6
Dames, S.7
Loffler, K.8
Fechtner, M.9
Arnold, W.10
-
33
-
-
0037348329
-
RNA interference targeting Fas protects mice from fulminant hepatitis
-
Song, E., Lee, S.K., Wang, J., Ince, N., Ouyang, N., Min, J., Chen, J., Shankar, P., and Lieberman, J. 2003. RNA interference targeting Fas protects mice from fulminant hepatitis. Nat. Med. 9: 347-351.
-
(2003)
Nat. Med
, vol.9
, pp. 347-351
-
-
Song, E.1
Lee, S.K.2
Wang, J.3
Ince, N.4
Ouyang, N.5
Min, J.6
Chen, J.7
Shankar, P.8
Lieberman, J.9
-
34
-
-
23844474160
-
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
-
Song, E., Zhu, P., Lee, S.K., Chowdhury, D., Kussman, S., Dykxhoorn, D.M., Feng, Y., Palliser, D., Weiner, D.B., Shankar, P., et al. 2005. Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat. Biotechnol. 23: 709-717.
-
(2005)
Nat. Biotechnol
, vol.23
, pp. 709-717
-
-
Song, E.1
Zhu, P.2
Lee, S.K.3
Chowdhury, D.4
Kussman, S.5
Dykxhoorn, D.M.6
Feng, Y.7
Palliser, D.8
Weiner, D.B.9
Shankar, P.10
-
35
-
-
9144247189
-
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
-
Soutschek, J., AkinC., A., Bramlage, B., Charisse, K., Constien, R., Donoghue, M., Elbashir, S., Geick, A., Hadwiger, P., Harborth, J., et al. 2004. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432: 173-178.
-
(2004)
Nature
, vol.432
, pp. 173-178
-
-
Soutschek, J.1
AkinC, A.2
Bramlage, B.3
Charisse, K.4
Constien, R.5
Donoghue, M.6
Elbashir, S.7
Geick, A.8
Hadwiger, P.9
Harborth, J.10
-
36
-
-
24744464786
-
Efficient delivery of small interfering RNA to bone- metastatic tumors by using atelocollagen in vivo
-
Takeshita, F., Minakuchi, Y., Nagahara, S., Honma, K., Sasaki, H., Hirai, K., Teratani, T., Namatame, N., Yamamoto, Y., Hanai, K., et al. 2005. Efficient delivery of small interfering RNA to bone- metastatic tumors by using atelocollagen in vivo. Proc. Natl. Acad. Sci. 102: 12177-12182.
-
(2005)
Proc. Natl. Acad. Sci
, vol.102
, pp. 12177-12182
-
-
Takeshita, F.1
Minakuchi, Y.2
Nagahara, S.3
Honma, K.4
Sasaki, H.5
Hirai, K.6
Teratani, T.7
Namatame, N.8
Yamamoto, Y.9
Hanai, K.10
-
37
-
-
0027174945
-
Complete vesicu- lation of Golgi membranes and inhibition of protein transport by a novel sea sponge metabolite, ilimaquinone
-
Takizawa, P.A., Yucel, J.K., Veit, B., Faulkner, D.J., Deerinck, T., Soto, G., Ellisman, M., and Malhotra, V. 1993. Complete vesicu- lation of Golgi membranes and inhibition of protein transport by a novel sea sponge metabolite, ilimaquinone. Cell 73: 1079-1090.
-
(1993)
Cell
, vol.73
, pp. 1079-1090
-
-
Takizawa, P.A.1
Yucel, J.K.2
Veit, B.3
Faulkner, D.J.4
Deerinck, T.5
Soto, G.6
Ellisman, M.7
Malhotra, V.8
-
38
-
-
11844283922
-
Gene knockdown with intrathecal siRNA of NMDA receptor NR2B subunit reduces formalin-induced nociception in the rat
-
Tan, P.H., Yang, L.C., Shih, H.C., Lan, K.C., and Cheng, J.T. 2005. Gene knockdown with intrathecal siRNA of NMDA receptor NR2B subunit reduces formalin-induced nociception in the rat. Gene Ther. 12: 59-66.
-
(2005)
Gene Ther
, vol.12
, pp. 59-66
-
-
Tan, P.H.1
Yang, L.C.2
Shih, H.C.3
Lan, K.C.4
Cheng, J.T.5
-
39
-
-
48849083479
-
-
Turner, J.J., Williams, D., Owen, D., and Gait, M.J. 2006. Disulfide conjugation of peptides to oligonucleotides and their analogs. In Current protocols in nucleic acid chemistry, Chap. 4, pp. 4.28.21-24.28.21. Wiley, New York.
-
Turner, J.J., Williams, D., Owen, D., and Gait, M.J. 2006. Disulfide conjugation of peptides to oligonucleotides and their analogs. In Current protocols in nucleic acid chemistry, Chap. 4, pp. 4.28.21-24.28.21. Wiley, New York.
-
-
-
-
40
-
-
33845630808
-
RNA targeting with peptide conjugates of oligonucleotides, siRNA and PNA
-
Turner, J.J., Jones, S., Fabani, M.M., Ivanova, G., Arzumanov, A.A., and Gait, M.J. 2007. RNA targeting with peptide conjugates of oligonucleotides, siRNA and PNA. Blood Cells Mol. Dis. 38: 1-7.
-
(2007)
Blood Cells Mol. Dis
, vol.38
, pp. 1-7
-
-
Turner, J.J.1
Jones, S.2
Fabani, M.M.3
Ivanova, G.4
Arzumanov, A.A.5
Gait, M.J.6
-
41
-
-
30644473108
-
Antibody-directed cell-type-specific delivery of siRNA
-
Vomlocher, H.P. 2006. Antibody-directed cell-type-specific delivery of siRNA. Trends Mol. Med. 12: 1-3.
-
(2006)
Trends Mol. Med
, vol.12
, pp. 1-3
-
-
Vomlocher, H.P.1
-
42
-
-
0031443467
-
The AMF-R tubule is a smooth ilimaquinone-sensitive subdomain of the endoplasmic reticulum
-
Wang, H.J., Benlimame, N., and Nabi, I. 1997. The AMF-R tubule is a smooth ilimaquinone-sensitive subdomain of the endoplasmic reticulum. J. Cell Sci. 110: 3043-3053.
-
(1997)
J. Cell Sci
, vol.110
, pp. 3043-3053
-
-
Wang, H.J.1
Benlimame, N.2
Nabi, I.3
-
43
-
-
24644446398
-
Ribo-gnome: The big world of small RNAs
-
Zamore, P.D. and Haley, B. 2005. Ribo-gnome: The big world of small RNAs. Science 309: 1519-1524.
-
(2005)
Science
, vol.309
, pp. 1519-1524
-
-
Zamore, P.D.1
Haley, B.2
-
44
-
-
0036074161
-
RNA interference in human cells is restricted to the cytoplasm
-
Zeng, Y. and Cullen, B.R. 2002. RNA interference in human cells is restricted to the cytoplasm. RNA 8: 855-860.
-
(2002)
RNA
, vol.8
, pp. 855-860
-
-
Zeng, Y.1
Cullen, B.R.2
|