Synthesis, hybridization characteristics, and fluorescence properties of oligonucleotides modified with nucleobase-functionalized locked nucleic acid adenosine and cytidine monomers

Journal of Organic Chemistry

Volumn 79, Issue 13, 2014, Pages 6256-6268

  Kaura, Mamta ^a   Kumar, Pawan ^a   Hrdlicka, Patrick J ^a  

^a UNIVERSITY OF IDAHO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; LOCKS (FASTENERS); MOLECULAR BIOLOGY; MONOMERS; NUCLEIC ACIDS;

BINDING AFFINITIES; BIOPHYSICAL PROPERTIES; ENZYMATIC STABILITY; FLUORESCENCE PROPERTIES; FUNCTIONALIZATIONS; FUTURE DESIGNS; LOCKED NUCLEIC ACID; MEDICINAL CHEMISTRY;

OLIGONUCLEOTIDES;

3 (4 N BENZOYL 5 ETHYNYLCYTOSIN 1 YL) 7 [2 CYANOETHOXY(DIISOPROPYLAMINO)PHOSPHINOXY] 1 (4,4' DIMETHOXYTRITYLOXYMETHYL) 2,5 DIOXABICYCLO[2.2.1]HEPTANE; 3 [4 N BENZOYL 5 (3 TRIFLUOROACETYLAMINOPROPYN 1 YL)CYTOSIN 1 YL] 7 [2 CYANOETHOXY(DIISOPROPYLAMINO)PHOSPHINOXYL] 1 (4,4' DIMETHOXYTRITYLOXYMETHYL) 2,5 DIOXABICYCLO[2.2.1]HEPTANE; 7 [2 CYANOETHOXY(DIISOPROPYLAMINO)PHOSPHINOXY] 1 (4,4' DIMETHOXYTRITYLOXYMETHYL) 3 [6 N [DIMETHYLAMINO]METHYLENE 8 [2 (1 PYRENYL)ETHYNYL]ADENIN 9 YL] 2,5 DIOXABICYCLO[2.2.1]HEPTANE; 7 [2 CYANOETHOXY(DIISOPROPYLAMINO)PHOSPHINOXY] 1 (4,4' DIMETHOXYTRITYLOXYMETHYL) 3 [6 N(DIMETHYLAMINO)METHYLENE 8 VINYLADENIN 9 YL] 2,5 DIOXABICYCLO[2.2.1]HEPTANE; ADENOSINE DERIVATIVE; CYTIDINE DERIVATIVE; DOUBLE STRANDED DNA; LOCKED NUCLEIC ACID; MONOMER; NUCLEIC ACID BASE; OLIGONUCLEOTIDE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; ADENOSINE; CYTIDINE; DNA; NUCLEIC ACID;

ABSORPTION; ARTICLE; BINDING AFFINITY; BIOPHYSICS; DENATURATION; DRUG SYNTHESIS; ENZYME STABILITY; FLUORESCENCE; HYBRIDIZATION; NUCLEAR OVERHAUSER EFFECT; ROTATING FRAME NUCLEAR OVERHAUSER EFFECT CORRELATION SPECTROSCOPY; SONOGASHIRA REACTION; STEADY STATE; CHEMISTRY; CONFORMATION; NUCLEIC ACID HYBRIDIZATION; PROCEDURES; SYNTHESIS;

ADENOSINE; CYTIDINE; DNA; FLUORESCENCE; NUCLEIC ACID CONFORMATION; NUCLEIC ACID HYBRIDIZATION; NUCLEIC ACIDS; OLIGONUCLEOTIDES;

EID: 84903732255     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo500994c     Document Type: Article

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