Functionalized 2̀-amino-α-L-LNA: Directed positioning of intercalators for DNA targeting

Journal of Organic Chemistry

Volumn 74, Issue 3, 2009, Pages 1070-1081

  Kumar, T Santhosh ^a   Madsen, Andreas S ^a   Østergaard, Michael E ^b   Sau, Sujay P ^b   Wengel, Jesper ^a   Hrdlicka, Patrick J ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b UNIVERSITY OF IDAHO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

[CARBONYL; AMINO ALCOHOLS; BIOPHYSICAL CHARACTERIZATIONS; BUILDING BLOCKS; CHEMICALLY MODIFIED; CHEMO-SELECTIVE; CIRCULAR DICHROISM SIGNALS; DETRIMENTAL EFFECTS; DIAGNOSTIC APPLICATIONS; DIASTEREOMER; DNA TARGETS; DUPLEX FORMATIONS; ENTROPIC CONTRIBUTIONS; ENZYMATIC STABILITIES; FUNCTIONALIZATION; FUNCTIONALIZED; INTERCALATORS; LOCKED NUCLEIC ACIDS; MOLECULAR MODELING STUDIES; PHOSPHITYLATION; PHOSPHORAMIDITES; POSITIONAL CONTROLS; PRECISE POSITIONING; PYRENE ABSORPTIONS;

ALCOHOLS; AMINATION; AMINES; AUDIO FREQUENCY AMPLIFIERS; BIOMOLECULES; DICHROISM; DNA; GENES; LOW NOISE AMPLIFIERS; MOLECULAR MODELING; MONOMERS; OLIGONUCLEOTIDES;

NUCLEIC ACIDS;

1 (4,4 DIMETHOXYTRITYLOXYMETHYL) 7 HYDROXY 5 (PYREN 1 YL)CARBONYL 3 (THYMIN 1 YL) 2 OXA 5 AZABICYCLO[2.2.1]HEPTANE; 2 N (PYREN 1 YL)CARBONYL 2 AMINO ALPHA LOCKED NUCLEIC ACID; 2 N ACETYL 2 AMINO ALPHA LOCKED NUCLEIC ACID; 7 (2 CYANOETHOXY DIISOPROPYLAMINO PHOSPHINOXY) 1 (4,4 DIMETHOXYTRITYLOXYMETHYL) 5 (PYREN 1 YL)CARBONYL 3 (THYMIN 1 YL) 2 OXA 5 AZABICYCLO[2.2.1]HEPTANE; ALCOHOL; AMINO ACID DERIVATIVE; HEPTANE DERIVATIVE; INTERCALATING AGENT; LOCKED NUCLEIC ACID; OLIGODEOXYRIBONUCLEOTIDE; PHOSPHORAMIDOUS ACID DERIVATIVE; PYRENE; UNCLASSIFIED DRUG; 7 (2 CYANOETHOXY(DIISOPROPYLAMINO)PHOSPHINOXY) 1 (4,4' DIMETHOXYTRITYLOXYMETHYL) 5 (9' FLUORENYLMETHOXYCARBONYL) 3 (THYMIN 1 YL) 2 OXA 5 AZABICYCLO(2.2.1)HEPTANE; 7-(2-CYANOETHOXY(DIISOPROPYLAMINO)PHOSPHINOXY)-1-(4,4'-DIMETHOXYTRITYLOXYMETHYL)-5-(9'-FLUORENYLMETHOXYCARBONYL)-3-(THYMIN-1-YL)-2-OXA-5-AZABICYCLO(2.2.1)HEPTANE; DNA; DRUG DERIVATIVE; OLIGONUCLEOTIDE; ORGANOPHOSPHORUS COMPOUND; PHOSPHORAMIDOUS ACID; PYRENE DERIVATIVE; THYMIDINE PHOSPHATE;

ARTICLE; CHEMICAL STRUCTURE; CIRCULAR DICHROISM; DENATURATION; DNA HYBRIDIZATION; ENTROPY; GENE TARGETING; MOLECULAR MODEL; SYNTHESIS; TEMPERATURE SENSITIVITY; CHEMISTRY; CONFORMATION; DRUG DELIVERY SYSTEM;

DNA; DRUG DELIVERY SYSTEMS; INTERCALATING AGENTS; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES; ORGANOPHOSPHORUS COMPOUNDS; PYRENES; THYMIDINE MONOPHOSPHATE;

EID: 60649099809     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo802037v     Document Type: Article

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