Conformationally constrained 2′-N,4′-C-ethylene-bridged thymidine (Aza-ENA-T): Synthesis, structure, physical, and biochemical studies of Aza-ENA-T-modified oligonucleotides

Journal of the American Chemical Society

Volumn 128, Issue 47, 2006, Pages 15173-15187

  Varghese, Oommen P ^a   Barman, Jharna ^a   Pathmasiri, Wimal ^a   Plashkevych, Oleksandr ^a   Honcharenko, Dmytro ^a   Chattopadhyaya, Jyoti ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CONFORMATIONS; ETHYLENE; MOLECULAR STRUCTURE; OLIGOMERS; PHYSICAL PROPERTIES; SYNTHESIS (CHEMICAL);

ANTISENSE OLIGONUCLEOTIDES (AON); BICYCLIC AMINES; BLOOD SERUM STABILITY; OLIGONUCLEOTIDES;

AMINES;

2' ARA TRIFLUOROMETHYLSULFONYL 4' CYANOMETHYLENE; 2' DEOXY 2' N,4'C ETHYLENE BRIDGED THYMIDINE; 5 BENZYLOXYMETHYL 8 BENZYLOXY 7 (THYMIN 1 YL) 2 AZA 6 OXABICYCLO[3.2.1]OCTANE; AMINE; ANTISENSE OLIGONUCLEOTIDE; CARBENOID; ETHYLENE DERIVATIVE; HETERODUPLEX; HYDROGEN; NITROGEN; OCTANE; PHOSPHORAMIDOUS ACID DERIVATIVE; PIPERIDINE DERIVATIVE; RIBONUCLEASE; RNA; SULFONYLUREA DERIVATIVE; THYMIDINE DERIVATIVE;

ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION KINETICS; CHIRALITY; CONFORMATIONAL TRANSITION; CYCLIZATION; DIASTEREOISOMER; NONHUMAN; NUCLEOTIDE METABOLISM; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; SOLID; THERMODYNAMICS;

BASE SEQUENCE; BRIDGED COMPOUNDS; DNA; DRUG STABILITY; HUMANS; KINETICS; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHODIESTERASE I; STEREOISOMERISM; THERMODYNAMICS; THYMIDINE;

EID: 33845224051     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0634977     Document Type: Article

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