An overview of sugar-modified oligonucleotides for antisense therapeutics

Chemistry and Biodiversity

Volumn 8, Issue 9, 2011, Pages 1616-1641

  Prakash, Thazha P ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

Antisense therapeutics; BNA; Nucleic acids; Oligonucleotides; RNA

Indexed keywords

2' DEOXY 2' FLUORORIBONUCLEOSIDE; 2' O (2 AMINO 2 OXOETHYL) ANTISENSE OLIGONUCLEOTIDE; 2' O [2 (AMINOOXY)ETHYL] ANTISENSE OLIGONUCLEOTIDE; 2' O [2 (DIMETHYLAMINO) 2 OXOETHYL] ANTISENSE OLIGONUCLEOTIDE; 2' O [2 (GUANIDINIUM)ETHYL] ANTISENSE OLIGONUCLEOTIDE; 2' O [2 (METHOXY)ETHYL] ANTISENSE OLIGONUCLEOTIDE; 2' O [2 (METHYLAMINO) 2 OXOETHYL] ANTISENSE OLIGONUCLEOTIDE; 2' O [2 (METHYLTHIO)ETHYL] ANTISENSE OLIGONUCLEOTIDE; 2' O [2 [(DIMETHYLAMINO)OXY]ETHYL] ANTISENSE OLIGONUCLEOTIDE; 2' O [2 [2 (DIMETHYLAMINO)ETHOXY]ETHYL] ANTISENSE OLIGONUCLEOTIDE; 2' O [2 [[(2 AMINOETHYL)(METHYL)AMINO]OXY]ETHYL] ANTISENSE OLIGONUCLEOTIDE; 2' O [2 [[(DIETHYL)AMINO]OXY]ETHYL] ANTISENSE OLIGONUCLEOTIDE; 2' O [2 [[(ISOPROPYL)(METHYL)AMINO]OXY]ETHYL] ANTISENSE OLIGONUCLEOTIDE; 2' O [2 [[2 (DIMETHYLAMINO)ETHYL]AMINO] 2 OXOETHYL) ANTISENSE OLICONUCLEOTIDE; ANTISENSE OLIGONUCLEOTIDE; ARABINO NUCLEIC ACID; BRIDGED NUCLEIC ACID; COMPLEMENTARY RNA; DNA; DOUBLE STRANDED DNA; FOMIVIRSEN; FURANOSE; MIPOMERSEN; NUCLEIC ACID; PHOSPHODIESTERASE; RIBONUCLEASE H; RNA; SUGAR; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ANTISENSE THERAPY; BINDING AFFINITY; CHEMICAL MODIFICATION; CIRCULAR DICHROISM; CRYSTAL STRUCTURE; DOSE RESPONSE; DRUG BINDING; DRUG CONFORMATION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; DRUG STABILITY; DRUG STRUCTURE; DRUG TARGETING; FAMILIAL HYPERCHOLESTEROLEMIA; GENE EXPRESSION; HUMAN; HYPERGLYCEMIA; HYPERLIPIDEMIA; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; NEOPLASM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PKA; PROTEIN EXPRESSION; REVIEW; RNA BINDING; RNA CLEAVAGE; STEREOCHEMISTRY; STRUCTURE ANALYSIS; THERMOSTABILITY;

CARBOHYDRATES; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES; OLIGONUCLEOTIDES, ANTISENSE; RIBONUCLEASE H;

EID: 80052913097     PISSN: 16121872     EISSN: 16121880     Source Type: Journal    
DOI: 10.1002/cbdv.201100081     Document Type: Review

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