Synthesis of cis - And trans-α-l-[4.3.0]bicyclo-DNA monomers for antisense technology: Methods for the diastereoselective formation of bicyclic nucleosides

Journal of Organic Chemistry

Volumn 78, Issue 18, 2013, Pages 9051-9063

  Hanessian, Stephen ^a   Schroeder, Benjamin R ^a   Merner, Bradley L ^a   Chen, Bin ^a   Swayze, Eric E ^b   Seth, Punit P ^b  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE PRECURSORS; ALLYLATION REACTIONS; ANTISENSE TECHNOLOGY; DIASTEREOSELECTIVE; DNA OLIGONUCLEOTIDES; OLIGONUCLEOTIDE SEQUENCES; RING CLOSING METATHESIS; THERMAL DENATURATIONS;

ALLYLATION; BIOMOLECULES; CARBOHYDRATES; CONDENSATION REACTIONS; DNA; OLIGONUCLEOTIDES;

STEREOSELECTIVITY;

BICYCLO COMPOUND; CARBOHYDRATE; COMPLEMENTARY DNA; COMPLEMENTARY RNA; DNA; LEWIS ACID; NUCLEIC ACID; NUCLEOSIDE DERIVATIVE; OLIGONUCLEOTIDE; PROLINE;

ALDOL REACTION; ALLYLATION; ARTICLE; CONFORMATIONAL TRANSITION; DENATURATION; GENE TECHNOLOGY; GRIGNARD REACTION; HUMAN; NUCLEOTIDE SEQUENCE; PROTEIN STABILITY; RING CLOSING METATHESIS; STEREOCHEMISTRY; SYNTHESIS; THERMOSTABILITY;

EID: 84884569654     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo401166q     Document Type: Article

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