Synthesis of 2′,4′-propylene-bridged (Carba-ENA) thymidine and its analogues: The engineering of electrostatic and steric effects at the bottom of the minor groove for nuclease and thermodynamic stabilities and elicitation of RNase H

Journal of Organic Chemistry

Volumn 75, Issue 21, 2010, Pages 7112-7128

  Liu, Yi ^a   Xu, Jianfeng ^a   Karimiahmadabadi, Mansoureh ^a   Zhou, Chuanzheng ^a   Chattopadhyaya, Jyoti ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL NATURE; DESTABILIZATION EFFECTS; DNA DUPLEXES; HIGH EFFICIENCY; HYBRID DUPLEX; MINOR GROOVES; OLIGODEOXYNUCLEOTIDES; RADICAL ADDITION; RNA DUPLEXES; RNASE H; SMALL VARIATIONS; STERIC EFFECT; THERMAL STABILITY; THERMAL STABILIZATION;

CHEMICAL STABILITY; ETHERS; PROPYLENE; THERMODYNAMIC STABILITY;

RNA;

2',4' PROPYLENE; ANTISENSE OLIGODEOXYNUCLEOTIDE; COMPLEMENTARY DNA; COMPLEMENTARY RNA; ETHER DERIVATIVE; LOCKED NUCLEIC ACID; NUCLEASE; NUCLEOSIDE DERIVATIVE; PROPYLENE; RIBONUCLEASE H; THYMIDINE DERIVATIVE; UNCLASSIFIED DRUG; ALKENE; DEOXYRIBONUCLEASE; DNA; EXONUCLEASE; OLIGODEOXYRIBONUCLEOTIDE; PHOSPHATE; RIBONUCLEASE; RNA; SPLEEN EXONUCLEASE; THYMIDINE;

ADDITION LINE; ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; CONTROLLED STUDY; ENZYME STABILITY; HUMAN; HYBRIDIZATION; INTERMETHOD COMPARISON; MALE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RING CLOSING METATHESIS; STATIC ELECTRICITY; STEREOCHEMISTRY; SYNTHESIS; THERMODYNAMICS; THERMOSTABILITY; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; NUCLEIC ACID HYBRIDIZATION; NUCLEOTIDE SEQUENCE; STEREOISOMERISM;

ALKENES; BASE SEQUENCE; DEOXYRIBONUCLEASES; DNA; EXONUCLEASES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; NUCLEIC ACID HYBRIDIZATION; OLIGODEOXYRIBONUCLEOTIDES; PHOSPHATES; RIBONUCLEASE H; RIBONUCLEASES; RNA; STATIC ELECTRICITY; STEREOISOMERISM; THERMODYNAMICS; THYMIDINE;

EID: 78049491301     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo101207d     Document Type: Article

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