Free-radical ring closure to conformationally locked α-l-carba-LNAs and synthesis of their oligos: Nuclease stability, target RNA specificity, and elicitation of RNase H

Journal of Organic Chemistry

Volumn 75, Issue 18, 2010, Pages 6122-6140

  Li, Qing ^a   Yuan, Fengfeng ^a   Zhou, Chuanzheng ^a   Plashkevych, Oleksandr ^a   Chattopadhyaya, Jyoti ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDES; EXONUCLEASE; GLYCOSIDIC TORSION; HETERODUPLEX; HIGHER EFFICIENCY; HUMAN BLOODS; HYBRID DUPLEX; INTRAMOLECULAR CYCLIZATIONS; LOCKED NUCLEIC ACID; MODIFIED NUCLEOTIDES; PHOSPHORAMIDITES; RADICAL RING; RNASE H; THERMAL DENATURATIONS; THERMAL STABILITY;

NUCLEIC ACIDS; OLIGONUCLEOTIDES; RNA; SUGAR (SUCROSE);

STABILITY;

6',7' ALPHA LEVO RIBO LOCKED NUCLEIC THYMIDINE; ALPHA LEVO CARBA LOCKED NUCLEIC ACID; ALPHA LEVO RIBO LOCKED NUCLEIC THYMIDINE; ANTISENSE OLIGONUCLEOTIDE; DNA; FREE RADICAL; NUCLEASE; NUCLEOSIDE; PHOSPHORAMIDOUS ACID DERIVATIVE; RIBONUCLEASE H; RNA; SPLEEN EXONUCLEASE; THYMIDINE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CIRCULAR DICHROISM; CONFORMATION; CONTROLLED STUDY; CYCLIZATION; DENATURATION; ENZYME STABILITY; HUMAN; HYDROPHOBICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PURIFICATION; SOLVATION; STRUCTURE ANALYSIS; SUBSTITUTION REACTION; SYNTHESIS; TEMPERATURE SENSE;

CYCLIZATION; FREE RADICALS; HUMANS; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES; OLIGONUCLEOTIDES, ANTISENSE; RIBONUCLEASE H; STEREOISOMERISM;

EID: 77956556303     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo100900v     Document Type: Article

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