C5-functionalized LNA: Unparalleled hybridization properties and enzymatic stability

ChemBioChem

Volumn 10, Issue 17, 2009, Pages 2740-2743

  Østergaard, Michael E ^a   Kumar, Pawan ^a,b   Baral, Bharat ^a   Raible, Daniel J ^a   Kumar, T Santhosh ^a,c   Anderson, Brooke A ^a   Guenther, Dale C ^a   Deobald, Lee ^a   Paszczynski, Andrzej J ^a   Sharma, Pawan K ^b   Hrdlicka, Patrick J ^a  

^a UNIVERSITY OF IDAHO   (United States)

^b KURUKSHETRA UNIVERSITY   (India)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Antisense agents; Bridged nucleic acids; Locked nucleic acids; Oligonucleotides; RNA targeting

Indexed keywords

LOCKED NUCLEIC ACID; MONOMER; PHOSPHODIESTERASE; PHOSPHORAMIDOUS ACID DERIVATIVE; SNAKE VENOM;

ARTICLE; BASE PAIRING; BINDING AFFINITY; CONTROLLED STUDY; DNA STRAND; ENZYMATIC DEGRADATION; ENZYME DEGRADATION; ENZYME STABILITY; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HYDROPHOBICITY; NUCLEAR MAGNETIC RESONANCE; NUCLEIC ACID HYBRIDIZATION; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN PURIFICATION; ULTRAVIOLET RADIATION;

BASE PAIRING; DNA; ENZYME STABILITY; MOLECULAR STRUCTURE; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES; ORGANOPHOSPHORUS COMPOUNDS; RNA;

EID: 73149109309     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200900500     Document Type: Article

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