Intramolecular free-radical cyclization reactions on pentose sugars for the synthesis of carba-LNA and carba-ENA and the application of their modified oligonucleotides as potential RNA targeted therapeutics

Chemical Reviews

Volumn 112, Issue 7, 2012, Pages 3808-3832

  Zhou, Chuanzheng ^a   Chattopadhyaya, Jyoti ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ENVIRONMENT; CYCLIZATION REACTIONS; FUNCTIONALIZATIONS; GRUBBS' CATALYST; HYDROPHILIC AND HYDROPHOBIC; LOCKED NUCLEIC ACID; MODIFIED OLIGONUCLEOTIDES; PENTOSE SUGARS; RING CLOSING METATHESIS; RNA RECOGNITION; VINYLMAGNESIUM BROMIDE;

ALDEHYDES; BROMINE COMPOUNDS; CYCLIZATION; ETHYLENE; OLIGONUCLEOTIDES; SCAFFOLDS;

RNA;

FREE RADICAL; LOCKED NUCLEIC ACID; OLIGONUCLEOTIDE; PENTOSE; RNA;

ANIMAL; CHEMISTRY; CYCLIZATION; GENETICS; HUMAN; METABOLISM; METHODOLOGY; MOLECULARLY TARGETED THERAPY; NUCLEOTIDE SEQUENCE; REVIEW; SYNTHESIS;

ANIMALS; BASE SEQUENCE; CHEMISTRY TECHNIQUES, SYNTHETIC; CYCLIZATION; FREE RADICALS; HUMANS; MOLECULAR TARGETED THERAPY; OLIGONUCLEOTIDES; PENTOSES; RNA;

EID: 84865092874     PISSN: 00092665     EISSN: 15206890     Source Type: Journal    
DOI: 10.1021/cr100306q     Document Type: Review

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