Analogues of a locked nucleic acid with three-carbon 2′,4′- linkages: Synthesis by ring-closing metathesis and influence on nucleic acid duplex stability and structure

Journal of Organic Chemistry

Volumn 71, Issue 20, 2006, Pages 7731-7740

  Albæk, Nanna ^a   Petersen, Michael ^a   Nielsen, Poul ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL MODIFICATION; MONOMERS; SATURATION (MATERIALS COMPOSITION); SYNTHESIS (CHEMICAL);

BICYCLIC MOIETY; LOCKED NUCLEIC ACID (LNA); OLIGODEOXYNUCLEOTIDE SEQUENCES;

NUCLEIC ACIDS;

2' DEOXYNUCLEOSIDE; 8 HYDROXY 1 HYDROXYMETHYL 6 (URACIL 1 YL) 7 OXABICYCLO[3.2.1]OCT 2 ENE; 8 HYDROXY 1 HYDROXYMETHYL 6 (URACIL 1 YL) 7 OXABICYCLO[3.2.1]OCTANE; BICYCLO COMPOUND; DOUBLE STRANDED DNA; MONOMER; NUCLEIC ACID; NUCLEOSIDE DERIVATIVE; OLIGODEOXYNUCLEOTIDE; OXYGEN; UNCLASSIFIED DRUG; URIDINE DERIVATIVE;

ARTICLE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; DNA RNA HYBRIDIZATION; MOLECULAR STABILITY; NUCLEIC ACID STRUCTURE; NUCLEOTIDE SEQUENCE; RING CLOSING METATHESIS; SYNTHESIS; ULTRAVIOLET RADIATION;

BASE SEQUENCE; CIRCULAR DICHROISM; DNA; NUCLEIC ACID DENATURATION; OLIGONUCLEOTIDES; OLIGONUCLEOTIDES, ANTISENSE; RNA; TEMPERATURE; URIDINE;

EID: 33749122260     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo061225g     Document Type: Article

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