Synthesis and pairing properties of oligodeoxynucleotides containing bicyclo-RNA and bicyclo-ANA modifications

Journal of Organic Chemistry

Volumn 77, Issue 14, 2012, Pages 5861-5869

  Haziri, Arben I ^a   Leumann, Christian J ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOCYCLIC RINGS; CONFORMATIONAL ANALYSIS; FURANOSE RING; H NMR SPECTROSCOPY; OH GROUP; OLIGODEOXYNUCLEOTIDES; PAIRING PROPERTIES; PHOSPHORAMIDITES; STERIC INTERACTIONS; SUGAR RESIDUES;

BIOMOLECULES; RNA;

CONFORMATIONS;

1 (2' ACETOXY 3',5' O DIBENZYL 3',5' ETHANO BETA DEXTRO RIBOFURANOSYL)THYMIDINE; 1 (2' HYDROXY 3',5' O DIBENZYL 3',5' ETHANO BETA DEXTRO ARABINOFURANOSYL)THYMIDINE; 1 (2' HYDROXY 3',5' O DIBENZYL 3',5' ETHANO BETA DEXTRO RIBOFURANOSYL)THYMIDINE; 1 (2' O METHYLSULFONYL 3',5' O DIBENZYL 3',5' ETHANO BETA DEXTRO ARABINOFURANOSYL)THYMIDINE; 1 (2' O TERT BUTYDIMETHYLSILYL 3',5' O DIBENZYL 3',5' ETHANO BETA DEXTRO ARABINOFURANOSYL)THYMIDINE; 1 (2' O TERT BUTYDIMETHYLSILYL 3',5' O DIBENZYL 3',5' ETHANO BETA DEXTRO RIBOFURANOSYL)THYMIDINE; 1 [3' HYDROXY 5' O (4,4' DIMETHOXYTRIPHENYLMETHYL) 2' O (TERT BUTYLDIMETHYLSILYL) 3',5' ETHANO BETA DEXTRO ARABINOFURANOSYL]THYMIDINE; 1 [3' HYDROXY 5' O [(4,4' DIMETHOXYTRIPHENYL)METHYL] 2' O (TERT BUTYLDIMETHYLLSILYL) 3',5' ETHANO BETA DEXTRO RIBOFURANOSYL]THYMIDINE; 1 [3' O (CYANOETHOXYDIISOPROPYLAMINOPHOSPHINO) 5' O [(4,4' DIMETHOXYTRIPHENYL)METHYL] 2' O (TERT BUTYLDIMETHYLSILYL) 3',5' ETHANO BETA DEXTRO ARABINOFURANOSYL]THYMIDINE; 1 [3' O [(CYANOETHOXY)(DIISOPROPYLAMINO)PHOSPHINO] 5' O [(4,4' DIMETHOXYTRIPHENYL)METHYL] 2' O (TERTBUTYLDIMETHYLLSILYL) 3',5' ETHANO BETA DEXTRO RIBOFURANOSYL)]THYMIDINE; 1 [3',5' DIHYDROXY 2' O (TERT BUTYLDIMETHYLSILYL) 3',5' ETHANO BETA DEXTRO ARABINOFURANOSYL]THYMIDINE; 1 [3',5' DIHYDROXY 2' O (TERT BUTYLDIMETHYLSILYL) 3',5' ETHANO BETA DEXTRO RIBOFURANOSYL]THYMIDINE; 2,2' ANHYDRO 1 (3',5' O DIBENZYL 3',5' ETHANO BETA DEXTRO ARABINOFURANOSYL)THYMIDINE; 3A,6 BIS(BENZYLOXY) 2 METHOXYHEXAHYDRO 2H CYCLOPENTA[B]FURAN 3 YL ACETATE; BICYCLO ARABINOTHYMIDINE; BICYCLO RIBOTHYMIDINE; COMPLEMENTARY DNA; COMPLEMENTARY RNA; N 4 BENZOYL 1 (2' ACETOXY 3',5' O DIBENZYL 3',5' ETHANO BETA DEXTRO RIBOFURANOSYL)CYTIDINE; N 4 BENZOYL 1 (2' HYDROXY 3',5' O DIBENZYL 3',5' ETHANO BETA DEXTRO RIBOFURANOSYL)CYTIDINE; N 4 BENZOYL 1 (2' O TERT BUTYDIMETHYLSILYL 3',5' O DIBENZYL 3',5' ETHANO BETA DEXTRO RIBOFURANOSYL)CYTIDINE; OLIGODEOXYNUCLEOTIDE; PHOSPHORAMIDOUS ACID DERIVATIVE; RNA; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DNA STRUCTURE; NUCLEOTIDE BINDING SITE; NUCLEOTIDE METABOLISM; PROTON NUCLEAR MAGNETIC RESONANCE;

BICYCLO COMPOUNDS; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; OLIGODEOXYRIBONUCLEOTIDES; RNA;

EID: 84864059335     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo300554w     Document Type: Article

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