Structure-based design of a highly constrained nucleic acid analogue: Improved duplex stabilization by restricting sugar pucker and torsion angle γ

Angewandte Chemie - International Edition

Volumn 51, Issue 45, 2012, Pages 11242-11245

  Hanessian, Stephen ^a   Schroeder, Benjamin R ^a   Giacometti, Robert D ^a   Merner, Bradley L ^a   Ostergaard, Michael ^b   Swayze, Eric E ^b   Seth, Punit P ^b  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b ISIS PHARMACEUTICALS   (United States)

Author keywords

antisense agents; conformational restriction; nucleosides; oligonucleotides; structure based design

Indexed keywords

ANTISENSE AGENT; CONFORMATIONAL RESTRICTION; CONSTRAINED NUCLEIC ACIDS; FURANOSE RING; NUCLEOSIDES; OLIGONUCLEOTIDE DUPLEXES; SINGLE MODE; STRUCTURE-BASED; SUGAR PUCKER; TORSION ANGLE;

NUCLEIC ACIDS; OLIGONUCLEOTIDES; SCAFFOLDS; SUGARS;

TORSIONAL STRESS;

NUCLEIC ACID; OLIGONUCLEOTIDE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; THERMODYNAMICS;

MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEIC ACID CONFORMATION; NUCLEIC ACIDS; OLIGONUCLEOTIDES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 84868149455     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201203680     Document Type: Article

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