Fine tuning of electrostatics around the internucleotidic phosphate through incorporation of modified 2′,4′-carbocyclic-LNAs and -ENAs leads to significant modulation of antisense properties

Journal of Organic Chemistry

Volumn 74, Issue 1, 2009, Pages 118-134

  Zhou, Chuanzheng ^a   Liu, Yi ^a   Andaloussi, Mounir ^a   Badgujar, Naresh ^a   Plashkevych, Oleksandr ^a   Chattopadhyaya, Jyoti ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI SENSES; ANTISENSE OLIGONUCLEOTIDES; BRIDGED NUCLEIC ACIDS; CHEMICAL EQUATIONS; CLEAVAGE RATES; CLEAVAGE SITES; DNA SYNTHESIS; ELECTROSTATIC INTERACTIONS; ENZYMATIC STABILITIES; FINE ADJUSTMENTS; FINE TUNING; HETERODUPLEX; HYBRID DUPLEXES; HYDROXYL GROUPS; LOCKED NUCLEIC ACIDS; METHYL SUBSTITUENTS; MINOR GROOVES; NUCLEASE RESISTANCES; PHOSPHATE LINKAGES; PHOSPHODIESTER; RNA CLEAVAGES; RNA INTERFERENCE TECHNOLOGIES; RNA TRANSLATIONS; RNASE H; SYNTHESIS OF;

AUDIO FREQUENCY AMPLIFIERS; CHEMICAL PROPERTIES; CHEMICAL REACTIONS; DNA; ELECTROSTATICS; ENZYMES; ETHYLENE; GENE EXPRESSION; GENES; LOW NOISE AMPLIFIERS; MODULATION; OLIGONUCLEOTIDES; ORGANIC ACIDS; RNA; TARGETS;

NUCLEIC ACIDS;

ACIDS, CARBOCYCLIC; DNA; ETHYLENES; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHATES; RNA; STATIC ELECTRICITY; STEREOISOMERISM; TIME FACTORS;

EID: 58149316214     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo8016742     Document Type: Article

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