A constrained tricyclic nucleic acid analogue of α-l-LNA: Investigating the effects of dual conformational restriction on duplex thermal stability

Journal of Organic Chemistry

Volumn 78, Issue 18, 2013, Pages 9064-9075

  Hanessian, Stephen ^a   Wagger, Jernej ^a   Merner, Bradley L ^a   Giacometti, Robert D ^a   Østergaard, Michael E ^b   Swayze, Eric E ^b   Seth, Punit P ^b  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONAL RESTRICTIONS; DUAL MODES; NUCLEIC ACID ANALOGUES; OLIGONUCLEOTIDE SEQUENCES; SUGAR MOIETY; THERMAL DENATURATIONS;

X RAY CRYSTALLOGRAPHY;

NUCLEIC ACIDS;

COMPLEMENTARY DNA; COMPLEMENTARY RNA; NUCLEIC ACID; OLIGONUCLEOTIDE; TRICYCLIC NUCLEIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ACETYLATION; ALDOL REACTION; ARTICLE; BENZYLATION; CONFORMATION; CRYSTAL STRUCTURE; CYCLIZATION; DENATURATION; GLYCOSYLATION; HYDROGENOLYSIS; HYDROLYSIS; ION EXCHANGE CHROMATOGRAPHY; NUCLEOTIDE SEQUENCE; OXIDATION; STEREOCHEMISTRY; SYNTHESIS; THERMOSTABILITY; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION;

EID: 84884553201     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo401170y     Document Type: Article

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