Antimicrobial activities of LL-37 and its truncated variants against Burkholderia thailandensis

International Journal of Antimicrobial Agents

Volumn 36, Issue 5, 2010, Pages 447-452

  Kanthawong, Sakawarat ^a   Bolscher, Jan G M ^b   Veerman, Enno C I ^b   van Marle, Jan ^c   Nazmi, Kamran ^b   Wongratanacheewin, Surasakdi ^a   Taweechaisupapong, Suwimol ^a,d  

^a KHON KAEN UNIVERSITY   (Thailand)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d KHON KAEN UNIVERSITY   (Thailand)

Author keywords

Antimicrobial peptide; Burkholderia pseudomallei; Burkholderia thailandensis; LL 37; Truncated variants

Indexed keywords

CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; IG 19; LL 31; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIAL MEMBRANE; BACTERICIDAL ACTIVITY; BACTERIUM TRANSFORMATION; BURKHOLDERIA; BURKHOLDERIA PSEUDOMALLEI; BURKHOLDERIA THAILANDENSIS; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE PERMEABILITY; COLONY FORMING UNIT F; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG POTENCY; DRUG SYNTHESIS; ELECTRON MICROSCOPY; HEMOLYSIS; HUMAN; HUMAN CELL; MEMBRANE DAMAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION;

ANTIMICROBIAL CATIONIC PEPTIDES; BURKHOLDERIA; CELL MEMBRANE; HUMANS; MICROBIAL VIABILITY; MICROSCOPY, ELECTRON, TRANSMISSION; MUTANT PROTEINS; SEQUENCE DELETION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77957652053     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2010.06.031     Document Type: Article

References (13)

1. Cheng A.C., Currie B.J. Melioidosis: epidemiology, pathophysiology, and management. Clin Microbiol Rev 2005, 18:383-416.
2. Thibault F.M., Hernandez E., Vidal D.R., Girardet M., Cavallo J.D. Antibiotic susceptibility of 65 isolates of Burkholderia pseudomallei and Burkholderia mallei to 35 antimicrobial agents. J Antimicrob Chemother 2004, 54:1134-1138.
3. Sorensen O.E., Follin P., Johnsen A.H., Calafat J., Tjabringa G.S., Hiemstra P.S., et al. Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3. Blood 2001, 97:3951-3959.
4. Travis S.M., Anderson N.N., Forsyth W.R., Espiritu C., Conway B.D., Greenberg E.P., et al. Bactericidal activity of mammalian cathelicidin-derived peptides. Infect Immun 2000, 68:2748-2755.
5. Kanthawong S., Nazmi K., Wongratanacheewin S., Bolscher J.G., Wuthiekanun V., Taweechaisupapong S. In vitro susceptibility of Burkholderia pseudomallei to antimicrobial peptides. Int J Antimicrob Agents 2009, 34:309-314.
6. Brett P.J., DeShazer D., Woods D.E. Burkholderia thailandensis sp. nov., a Burkholderia pseudomallei-like species. Int J Syst Bacteriol 1998, 48:317-320.
7. Smith M.D., Angus B.J., Wuthiekanun V., White N.J. Arabinose assimilation defines a nonvirulent biotype of Burkholderia pseudomallei. Infect Immun 1997, 65:4319-4321.
8. Haraga A., West T.E., Brittnacher M.J., Skerrett S.J., Miller S.I. Burkholderia thailandensis as a model system for the study of the virulence-associated type III secretion system of Burkholderia pseudomallei. Infect Immun 2008, 76:5402-5411.
9. Den Hertog A.L., van Marle J., Veerman E.C., Valentijn-Benz M., Nazmi K., Kalay H., et al. The human cathelicidin peptide LL-37 and truncated variants induce segregation of lipids and proteins in the plasma membrane of Candida albicans. Biol Chem 2006, 387:1495-1502.
10. Van der Kraan M.I., van Marle J., Nazmi K., Groenink J., van't Hof W., Veerman E.C., et al. Ultrastructural effects of antimicrobial peptides from bovine lactoferrin on the membranes of Candida albicans and Escherichia coli. Peptides 2005, 26:1537-1542.
11. Oren Z., Lerman J.C., Gudmundsson G.H., Agerberth B., Shai Y. Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity. Biochem J 1999, 341:501-513.
12. Glass M.B., Gee J.E., Steigerwalt A.G., Cavuoti D., Barton T., Hardy R.D., et al. Pneumonia and septicemia caused by Burkholderia thailandensis in the United States. J Clin Microbiol 2006, 44:4601-4604.
13. Molhoek E.M., den Hertog A.L., de Vries A-MBC, Nazmi K., Veerman E.C.I., Hartgens F.C., et al. Structure-function relationship of the human antimicrobial peptide LL-37 and LL-37 fragments in the modulation of TLR responses. Biol Chem 2009, 390:295-303.