Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response

Science

Volumn 311, Issue 5768, 2006, Pages 1770-1773

  Liu, Philip T ^a,b   Stenger, Steffen ^c   Li, Huiying ^a   Wenzel, Linda ^c   Tan, Belinda H ^a,b   Krutzik, Stephan R ^b   Ochoa, Maria Teresa ^b   Schauber, Jürgen ^d   Wu, Kent ^a   Meinken, Christoph ^c   Kamen, Diane L ^e   Wagner, Manfred ^f   Bals, Robert ^g   Steinmeyer, Andreas ^h   Zügel, Ulrich ^h   Gallo, Richard L ^d   Eisanberg, David ^a   Hewison, Martin ⁱ   Hollis, Bruce W ^e   Adams, John S ⁱ   Bloom, Barry R ^j   Modlin, Robert L ^a,b   more..

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^f KLINIKUM NÜRNBERG   (Germany)

^g PHILIPPS UNIVERSITY MARBURG   (Germany)

^h BAYER PHARMA AG   (Germany)

ⁱ CEDARS SINAI MEDICAL CENTER   (United States)

^j HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BACTERIA; GENES; IMMUNOLOGY; MICROBIOLOGY; RNA;

IMMUNITY; PEPTIDE CATHELICIDIN; RNA INDUCTION; VITAMIN D;

VITAMINS;

25 HYDROXYVITAMIN D; CATHELICIDIN; MESSENGER RNA; NITRIC OXIDE; OXYGENASE; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; VITAMIN D; VITAMIN D 1 HYDROXYLASE; VITAMIN D RECEPTOR;

ANTIMICROBIAL ACTIVITY;

AFRICAN AMERICAN; ANTIMICROBIAL ACTIVITY; ARTICLE; GENE INDUCTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFECTION SENSITIVITY; MACROPHAGE; MONOCYTE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; RECEPTOR UPREGULATION; TUBERCULOSIS;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; AFRICAN AMERICANS; ANTIMICROBIAL CATIONIC PEPTIDES; CALCITRIOL; COLONY COUNT, MICROBIAL; DENDRITIC CELLS; DISEASE SUSCEPTIBILITY; HUMANS; IMMUNITY, NATURAL; MACROPHAGES; MONOCYTES; MYCOBACTERIUM TUBERCULOSIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, CALCITRIOL; RNA, MESSENGER; STEROID HYDROXYLASES; TOLL-LIKE RECEPTORS; TUBERCULOSIS; UP-REGULATION;

MURINAE; MYCOBACTERIUM TUBERCULOSIS;

EID: 33645224419     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1123933     Document Type: Article

References (20)

1. S. Tauszig, E. Jouanguy, J. A. Hoffmann, J. L. Imler, Proc. Natl. Acad. Sci. U.S.A. 97, 10520 (2000).
2. R. L. Modlin, G. Cheng, Nat. Med. 10, 1173 (2004).
3. J. Chan, Y. Xing, R. S. Magliozzo, B. R. Bloom, J. Exp. Med. 175, 1111 (1992).
4. J. D. MacMicking et al., Cell 81, 641 (1995).
5. S. Thoma-Uszynski et al., Science 291, 1544 (2001).
6. Materials and methods are available as supporting material on Science Online.
7. J. Roth, T. Vogl, C. Sorg, C. Sunderkotter, Trends Immunol. 24, 155 (2003).
8. T. T. Wang et al., J. Immunol. 173, 2909 (2004).
9. K. A. Rockett et al., Infect. Immun. 66, 5314 (1998).
10. L. M. Sly, M. Lopez, W. M. Nauseef, N. E. Reiner, J. Biol. Chem. 276, 35482 (2001).
11. L. Y. Matsuoka, J. Wortsman, J. G. Haddad, P. Kolm, B. W. Hollis, Arch. Dermatol. 127, 536 (1991).
12. W. W. Stead, J. W. Senner, W. T. Reddick, J. P. Lofgren, N. Engl. J. Med. 322, 422 (1990).
13. A. R. Rich, The Pathogenesis of Tuberculosis (Charles C Thomas, Springfield, IL, 1944).
14. All volunteers in the study were categorized by self-identification or visual determination as African Americans or Caucasians (non-Hispanic, White). There were 19 African Americans and 14 Caucasians studied in Fig. 4, D and E. Although the studies were performed using samples from African Americans, we believe that the implications are likely to be relevant for all individuals of African descent and possibly of Asian decent. Future studies will be directed towards comparing responses according to measured skin pigmentation.
15. S. Stenger et al., Science 282, 121 (1998).
16. P. F. Barnes, R. L. Modlin, D. D. Bikle, J. S. Adams, J. Clin. Invest. 83, 1527 (1989).
17. C. J. Hertz et al., J. Immunol. 171, 6820 (2003).
18. E. Giovannucci, Cancer Causes Control 16, 83 (2005).
19. L. Bornman et al., J. Infect. Dis. 190, 1631 (2004).
20. We would like to thank G. Cheng at UCLA for his helpful discussion and O. Sorensen for the cathelicidin antibody. This work was supported by NIH grants AI47868, AI22553, HD043921, AR50626, AI48176, AI052453, AR45676, and RR00425; and also by the Deutsche Forschungsgemeinschaft (SFB 643 and GRK 592); Deutsche Akademie der Naturforscher Leopoldina; and U.S. Department of Veterans Affairs Merit Award.