Transmembrane pores formed by human antimicrobial peptide LL-37

Biophysical Journal

Volumn 100, Issue 7, 2011, Pages 1688-1696

  Lee, Chang Chun ^a   Sun, Yen ^a   Qian, Shuo ^b   Huang, Huey W ^a  

^a RICE UNIVERSITY   (United States)

^b OAK RIDGE NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79959644039     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2011.02.018     Document Type: Article

References (50)

1. Zanetti, M. 2004 Cathelicidins, multifunctional peptides of the innate immunity. J. Leukoc. Biol. 39:39-48. (Pubitemid 38166778)
2. Turner, J., Y. Cho,..., R. I. Lehrer. 1998 Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils. Antimicrob. Agents Chemother. 2206:2206-2214. (Pubitemid 28420351)
3. Scott, M. G., D. J. Davidson,..., R. E. Hancock. 2002 The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses. J. Immunol. 3883:3883-3891.
4. Koczulla, R., G. von Degenfeld,..., R. Bals. 2003 An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J. Clin. Invest. 1665:1665-1672. (Pubitemid 38057748)
5. Zaiou, M. 2007 Multifunctional antimicrobial peptides: therapeutic targets in several human diseases. J. Mol. Med. 317:317-329. (Pubitemid 46452258)
6. De, Y., Q. Chen,..., O. Chertov. 2000 LL-37, the neutrophil granuleand epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J. Exp. Med. 1069:1069-1074.
7. Zasloff, M. 2002 Antimicrobial peptides of multicellular organisms. Nature. 389:389-395. (Pubitemid 34100944)
8. Oren, Z., J. C. Lerman,..., Y. Shai. 1999 Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity. Biochem. J. 501:501-513. (Pubitemid 29389178)
9. Porcelli, F., R. Verardi,..., G. Veglia. 2008 NMR structure of the cathelicidin-derived human antimicrobial peptide LL-37 in dodecylphosphocholine micelles. Biochemistry. 5565:5565-5572. (Pubitemid 351705167)
10. Henzler Wildman, K. A., D. K. Lee, and A. Ramamoorthy. 2003 Mechanism of lipid bilayer disruption by the human antimicrobial peptide, LL-37. Biochemistry. 6545:6545-6558. (Pubitemid 36665830)
11. Sood, R., Y. Domanov,..., P. K. Kinnunen. 2008 Binding of LL-37 to model biomembranes: insight into target vs host cell recognition. Biochim. Biophys. Acta. 983:983-996.
12. Caillé, A. 1972 Physique cristalline: remarques sur la diffusion des rayons X dans les smectiques A. C. R. Acad. Sci. Paris Ser. B. 891:891-893.
13. Lei, N., C. R. Safinya, and R. F. Bruinsma. 1995 Discrete harmonic model for stacked membranes: theory and experiment. J. Phys. II. 1155:1155-1163.
14. Safinya, C. R., D. Roux,..., A. M. Bellocq. 1986 Steric interactions in a model multimembrane system: a synchrotron X-ray study. Phys. Rev. Lett. 2718:2718-2721.
15. Wack, D. C., and W. W. Webb. 1989 Measurement by X-ray diffraction methods of the layer compressional elastic constant B in the lyotropic smectic-A (L-α) phase of the lecithin-water system. Phys. Rev. A. 1627:1627-1636.
16. Wu, Y., H. W. Huang, and G. A. Olah. 1990 Method of oriented circular dichroism. Biophys. J. 797:797-806. (Pubitemid 20111238)
17. Huang, H. W. 2000 Action of antimicrobial peptides: two-state model. Biochemistry. 8347:8347-8352. (Pubitemid 30489931)
18. Lee, M. T., W. C. Hung,..., H. W. Huang. 2008 Mechanism and kinetics of pore formation in membranes by water-soluble amphipathic peptides. Proc. Natl. Acad. Sci. USA. 5087:5087-5092. (Pubitemid 351738514)
19. Ludtke, S., K. He, and H. Huang. 1995 Membrane thinning caused by magainin 2. Biochemistry. 16764:16764-16769. (Pubitemid 26011801)
20. Yang, L., and H. W. Huang. 2003 A rhombohedral phase of lipid containing a membrane fusion intermediate structure. Biophys. J. 1808:1808-1817. (Pubitemid 36322942)
21. He, K., S. J. Ludtke,..., H. W. Huang. 1996 Neutron scattering in the plane of membranes: structure of alamethicin pores. Biophys. J. 2659:2659-2666. (Pubitemid 26000964)
22. Powers, L., and P. S. Pershan. 1977 Monodomain samples of dipalmitoyl phosphatidylcholine with varying concentrations of water and other ingredients. Biophys. J. 137:137-152. (Pubitemid 8220668)
23. Ladokhin, A. S., and S. H. White. 2004 Interfacial folding and membrane insertion of a designed helical peptide. Biochemistry. 5782:5782-5791. (Pubitemid 38623612)
24. Burck, J., S. Roth,..., A. S. Ulrich. 2008 Conformation and membrane orientation of amphiphilic helical peptides by OCD. Biophys. J. 3872:3872-3881.
25. Cheng, J. T., J. D. Hale,..., S. K. Straus. 2009 Effect of membrane composition on antimicrobial peptides aurein 2.2 and 2.3 from Australian southern bell frogs. Biophys. J. 552:552-565.
26. Lynn, G. W., W. T. Heller,..., D. A. Myles. 2006 Bio-SANS-a dedicated facility for neutron structural biology at Oak Ridge National Laboratory. Condens. Matter. 385-880:880-882. (Pubitemid 44792912)
27. Lee, C. C., Y. Sun, and H. W. Huang. 2010 Membrane-mediated peptide conformation change from a-monomers to b-aggregates. Biophys. J. 2236:2236-2245.
28. Yang, L., T. M. Weiss, and H. W. Huang. 2000 Crystallization of antimicrobial pores in membranes: Magainin and protegrin. Biophys. J. 2002:2002-2009.
29. Sun, Y., W. C. Hung,..., H. W. Huang. 2009 Interaction of tea catechin (-)-epigallocatechin gallate with lipid bilayers. Biophys. J. 1026:1026-1035.
30. Chen, F. Y., W. C. Hung, and H. W. Huang. 1997 Critical swelling of phospholipid bilayers. Phys. Rev. Lett. 4026:4026-4029. (Pubitemid 127645145)
31. Johansson, J., G. H. Gudmundsson,..., B. Agerberth. 1998 Conformation-dependent antibacterial activity of the naturally occurring human peptide LL-37. J. Biol. Chem. 3718:3718-3724. (Pubitemid 28109800)
32. Terwilliger, T. C., L. Weissman, and D. Eisenberg. 1982 The structure of melittin in the form I crystals and its implication for melittin's lytic and surface activities. Biophys. J. 353:353-361. (Pubitemid 12150028)
33. Fox, Jr., R. O., and F. M. Richards. 1982 A voltage-gated ion channel model inferred from the crystal structure of alamethicin at 1.5-A resolution. Nature. 325:325-330. (Pubitemid 13196895)
34. Yang, L., T. A. Harroun,..., H. W. Huang. 2001 Barrel-stave model or toroidal model? a case study on melittin pores. Biophys. J. 1475:1475-1485. (Pubitemid 32783588)
35. Ludtke, S. J., K. He,..., H. W. Huang. 1996 Membrane pores induced by magainin. Biochemistry. 13723:13723-13728. (Pubitemid 26363914)
36. Yang, L., T. A. Harroun,..., H. W. Huang. 1998 Neutron off-plane scattering of aligned membranes. I. Method of measurement. Biophys. J. 641:641-645. (Pubitemid 28357506)
37. Yang, L., T. M. Weiss,..., H. W. Huang. 1999 Supramolecular structures of peptide assemblies in membranes by neutron off-plane scattering: method of analysis. Biophys. J. 2648:2648-2656. (Pubitemid 29519510)
38. Qian, S., W. Wang,..., H. W. Huang. 2008 Structure of transmembrane pore induced by Bax-derived peptide: evidence for lipidic pores. Proc. Natl. Acad. Sci. USA. 17379:17379-17383.
39. Qian, S., W. Wang,..., H. W. Huang. 2008 Structure of the alamethicin pore reconstructed by X-ray diffraction analysis. Biophys. J. 3512:3512-3522.
40. Mecke, A., D. K. Lee,..., M. M. Banaszak Holl. 2005 Membrane thinning due to antimicrobial peptide binding: an atomic force microscopy study of MSI-78 in lipid bilayers. Biophys. J. 4043:4043-4050. (Pubitemid 41725624)
41. Pabst, G., S. Danner,..., J. Katsaras. 2007 Entropy-driven softening of fluid lipid bilayers by alamethicin. Langmuir. 11705:11705-11711. (Pubitemid 350133018)
42. Huang, H. W. 2009 Free energies of molecular bound states in lipid bilayers: lethal concentrations of antimicrobial peptides. Biophys. J. 3263:3263-3272.
43. Lee, M. T., F. Y. Chen, and H. W. Huang. 2004 Energetics of pore formation induced by membrane active peptides. Biochemistry. 3590:3590-3599. (Pubitemid 38391714)
44. Tamba, Y., and M. Yamazaki. 2005 Single giant unilamellar vesicle method reveals effect of antimicrobial peptide magainin 2 on membrane permeability. Biochemistry. 15823:15823-15833. (Pubitemid 41746913)
45. Kwok, R., and E. Evans. 1981 Thermoelasticity of large lecithin bilayer vesicles. Biophys. J. 637:637-652. (Pubitemid 11053380)
46. Longo, M. L., A. J. Waring,..., D. A. Hammer. 1998 Area expansion and permeation of phospholipid membrane bilayer by influenza fusion peptides and melittin. Langmuir. 2385:2385-2395. (Pubitemid 128567702)
47. Sun, Y., C. C. Lee,..., H. W. Huang. 2008 The bound states of amphipathic drugs in lipid bilayers: study of curcumin. Biophys. J. 2318:2318-2324.
48. Tamba, Y., H. Ariyama,..., M. Yamazaki. 2010 Kinetic pathway of antimicrobial peptide magainin2 induced pore formation in lipid membranes. J. Phys. Chem. B. 12018:12018-12026.
49. Fuertes, G., A. J. Garcia-Saez,..., J. Salgado. 2010 Pores formed by baxa5 relax to a smaller size and keep at equilibrium. Biophys. J. 2917:2917-2925.
50. Soscia, S. J., J. E. Kirby,..., R. D. Moir. 2010 The Alzheimer's disease-associated amyloid b-protein is an antimicrobial peptide. PLoS ONE. 5:e9505.