Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils

Antimicrobial Agents and Chemotherapy

Volumn 42, Issue 9, 1998, Pages 2206-2214

  Turner, Jeffrey ^a   Cho, Yoon ^a   Dinh, Nhu Nguyen ^a   Waring, Alan J ^a   Lehrer, Robert I ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; DEFENSIN; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BURKHOLDERIA CEPACIA; CANDIDA ALBICANS; ESCHERICHIA COLI; LISTERIA MONOCYTOGENES; MEMBRANE PERMEABILITY; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEUS MIRABILIS; PSEUDOMONAS AERUGINOSA; SALMONELLA TYPHIMURIUM; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

EID: 0031686776     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.42.9.2206     Document Type: Article

References (53)

1. Agerberth, B., H. Gunne, J. Odeberg, P. Kogner, H. G. Boman, and G. H. Gudmundsson. 1995. FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis. Proc. Natl. Acad. Sci. USA 92:195-199.
2. Bruch, M. D., M. M. Dhingra, and L. M. Gierasch. 1991. Side chain-back-bone hydrogen bonding contributes to helix stability in peptides derived from an α-helical region of carboxypeptidase A. Proteins Struct. Funct. Genet. 10: 130-139.
3. Chen, C., R. Brock, F. Luh, P.-J. Chou, J. W. Larrick, R.-F. Huang, and T.-H. Huang. 1995. The solution structure of the active domain of CAP18 - a lipopolysaccharide binding protein from rabbit leukocytes. FEBS Lett. 370: 46-52.
4. Chen, Y. H., J. T. Yang, and K. H. Chau. 1974. Determination of the helix and β form of proteins in aqueous by circular dichroism. Biochemistry 13: 3350-3359.
5. DeLeo, F. R., and M. T. Quinn. 1996. Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins. J. Leukocyte Biol. 60: 677-691.
6. Eisenberg, D., R. M. Weiss, T. C. Terwillinger, and W. Wilcox. 1982. Hydrophobic moments and protein structure. Faraday Symp. Chem. Soc. 17: 109-116.
7. 106-138-IgG. that binds and neutralizes endotoxin and kills gram-negative bacteria. J. Infect. Dis. 175:621-632.
8. Frohm, M., B. Agerberth, G. Ahangari, M. Stahle-Backdahl, S. Liden, H. Wigzell, and G. H. Gudmundsson. 1997. The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders. J. Biol. Chem. 272:15258-15263.
9. Gallo, R. L., K. J. Kim, M. Bernfield, C. A. Kozak, M. Zanetti, L. Merluzzi, and R. Gennaro. 1997. Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse. J. Biol. Chem. 272:13088-13093.
10. Ganz, T., and R. I. Lehrer. 1997. Antimicrobial peptides of leukocytes. Curr. Opin. Hematol. 4:53-58.
11. Greenfield, N., and G. Fasman. 1967. Computed circular dichroism spectra for the evaluation of protein conformation. Biochemistry 8:4108-4115.
12. Groisman, E. A., F. Heffron, and F. Solomon. 1992. Molecular genetic analysis of the Escherichia coli phoP locus. J. Bacteriol. 174:486-491.
13. Gudmundsson, G. H., B. Agerberth, J. Odeberg, T. Bergman, B. Olsson, and R. Salcedo. 1996. The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes. Eur. J. Biochem. 238:325-332.
14. Guo, L., K. B. Lim, J. S. Gunn, B. Bainbridge, R. P. Darveau, M. Hackett, and S. I. Miller. 1997. Regulation of lipid A modifications by Salmonella typhimurium virulence genes phoP-phoQ. Science 276:250-253.
15. Hampton, M. B., A. J. Kettle, and C. C. Winterbourn. 1996. Involvement of superoxide and myeloperoxidase in oxygen-dependent killing of Staphylococcus aureus by neutrophils. Infect. Immun. 64:3512-3517.
16. Harwig, S. S. L., T. Ganz, and R. I. Lehrer. 1994. Neutrophil defensins: purification, characterization and antimicrobial testing. Methods Enzymol. 236:163-172.
17. Harwig, S. S. L., A. J. Waring, H. J. Yang, Y. Cho, L. Tan, and R. I. Lehrer. 1996. Intramolecular disulfide bonds enhance the antimicrobial and lytic activities of protegrins at physiological sodium chloride concentrations. Eur. J. Biochem. 240:352-357.
18. Hirata, M., Y. Shimomura, M. Yoshida, J. G. Morgan, L. I. Palings, D. Wilson, M. H. Yen, S. C. Wright, and J. W. Larrick. 1994. Characterization of a rabbit cationic protein (CAP18) with lipopolysaccharide-inhibitory activity. Infect. Immun. 62:1421-1426.
19. Johnson, W. C., Jr. 1990. Protein secondary structure and circular dichroism: a practical guide. Proteins Struct. Funct. Genet. 7:205-214.
20. Johnston, C., D. A. Pegues, C. J. Hueck, A. Lee, and S. I. Miller. 1996. Transcriptional activation of Salmonella typhimurium invasion genes by a member of the phosphorylated response-regulator superfamily. Mol. Microbiol. 22:715-727.
21. Kokryakov, V. N., S. S. L. Harwig, E. A. Panyutich, A. A. Shevchenko, G. M. Aleshina, O. V. Shamova, H. A. Korneva, and R. I. Lehrer. 1993. Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins. FEBS Lett. 327:231-236.
22. Kopitar, M., A. Ritonja, T. Popovic, D. Gabrijelcic, I. Krizaj, and V. Turk. 1989. A new type of low-molecular mass cysteine proteinase inhibitor from pig leukocytes. Hoppe-Seyler's Biol. Chem. 370:1145-1151.
23. Larrick, J. W., M. Hirata, R. F. Balint, J. Lee, J. Zhong, and S. C. Wright. 1995. Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein. Infect. Immun. 63:1291-1297.
24. Larrick, J. W., M. Hirata, Y. Shimomoura, M. Yoshida, H. Zheng, J. Zhong, and S. C. Wright. 1993. Antimicrobial activity of rabbit CAP18-derived peptides. Antimicrob. Agents Chemother. 37:2534-2539.
25. Larrick, J. W., M. Hirata, H. Zheng, J. Zhong, D. Bolin, J.-M. Cavaillon, H. S. Warren, and S. C. Wright. 1994. A novel granulocyte-derived peptide with lipopolysaccharide-neutralizing activity. J. Immunol. 152:231-240.
26. Larrick, J. W., J. G. Morgan, I. Palings, M. Hirata, and M. H. Yen. 1991. Complementary DNA sequence of rabbit CAP-18. A unique lipopolysaccharide binding protein. Biochem. Biophys. Res. Commun. 179:170-175.
27. Lehrer, R. I., A. Barton, K. A. Daher, S. S. L. Harwig, T. Ganz, and M. E. Selsted. 1989. Interaction of human defensins with Escherichia coli: mechanism of bactericidal activity. J. Clin. Invest. 84:553-561.
28. Lehrer, R. I., A. Barton, and T. Ganz. 1988. Concurrent assessment of inner and outer membrane permeabilization and bacteriolysis in E. coli by multiple-wavelength spectrophotometry. J. Immunol. Methods 108:153-158.
29. Levy, O. 1996. Antibiotic proteins of polymorphonuclear leukocytes. Eur. J. Haematol. 56:263-277.
30. Levy, O., C. E. Ooi, P. Elsbach, M. E. Doerfler, R. I. Lehrer, and J. Weiss. 1995. Antibacterial proteins of granulocytes differ in interaction with endotoxin. Comparison of bactericidal/permeability-increasing protein, p15s, and defensins. J. Immunol. 154:5403-5410.
31. Levy, O., C. E. Ooi, J. Weiss, R. I. Lehrer, and P. Elsbach. 1994. Individual and synergistic effects of rabbit gianulocyte proteins on Escherichia coli. J. Clin. Invest. 94:672-682.
32. Mardiney, M., III, S. H. Jackson, S. K. Spratt, F. Li, S. M. Holland, and H. L. Malech. 1997. Enhanced host defense after gene transfer in the murine p47phox-deficient model of chronic granulomatous disease. Blood 89:2268-2275.
33. Moore, R. A., N. C. Bates, and R. E. W. Hancock. 1986. Interaction of polycationic antibiotics with Pseudomonas aeruginosa lipopolysaccharide and lipid A studied by using dansyl-polymyxin. Antimicrob. Agents Chemother. 29:496-500.
34. National Committee for Clinical Laboratory Standards. 1993. Document M7-A3. National Committee for Clinical Laboratory Standards. Wayne, Pa.
35. Panyutich, A., J. Shi, P. L. Boutz, C. Zhao, and T. Ganz. 1997. Porcine polymorphonuclear leukocytes generate extracellular microbicidal activity by elastase-mediated activation of secreted proprotegrins. Infect. Immun. 65: 978-985.
36. Rice, W. G., T. Ganz, J. M. Kinkade, Jr., M. E. Selsted, R. I. Lehrer, and R. T. Parmley. 1987. Defensin-rich granules of human neutrophils. Blood 70: 757-765.
37. Ritonja, A., M. Kopitar, R. Jerala, and V. Turk. 1989. Primary structure of a new cysteine proteinase inhibitor from pig leukocytes. FEBS Lett. 255:211-214.
38. Rost, B., and C. Sander. 1993. Prediction of protein secondary structure at better the 70% accuracy. J. Mol. Biol. 232:584-599.
39. Schindler, M., and M. J. Osborn. 1979. Interaction of divalent cations and polymyxin B with lipopolysaccharide. Biochemistry 18:4425-4430.
40. Scocchi, M., B. Skerlavaj, D. Romeo, and R. Gennaro. 1992. Proteolytic cleavage by neutrophil elastase converts inactive storage proforms to antibacterial bactenecins. Eur. J. Biochem. 209:589-595.
41. Sorensen, O., K. Arnljots, J. B. Cowland, D. F. Bainton, and N. Borregaard. 1997. The human antibacterial cathelicidin, hCAP-18, is synthesized in myelocytes and metamyelocytes and localized to specific granules in neutrophils. Blood 90:2796-2803.
42. Sorensøn, O., J. B. Cowland, J. Askaa, and N. Borregaard. 1997. An ELISA for hCAP-18, the cathelicidin present in human neutrophils and plasma. J. Immunol. Methods 206:53-59.
43. Speert, D. P., M. Bond, R. C. Woodman, and J. T. Curnutte. 1994. Infection with Pseudomonas cepacia in chronic granulomatous disease: role of non-oxidative killing by neutrophils in host defense. J. Infect. Dis. 170:1524-1531.
44. Steinberg, D., and R. I. Lehrer. 1997. Designer assays for antimicrobial peptides. Methods Mol. Biol. 78:169-186.
45. Tasaka, S., A. Ishizaka, T. Urano, K. Sayama, F. Sakamaki, H. Nakamura, T. Terashima, Y. Waki, K. Soejima, M. Nakamura, H. Matsubara, S. Fujishima, M. Kanazawa, and J. W. Larrick. 1996. A derivative of cationic antimicrobial protein attenuates lung injury by suppressing cell adhesion. Am. J. Respir. Cell. Mol. Biol. 15:738-744.
46. Teuber, M., and I. R. Miller. 1977. Selective binding of polymyxin B to negatively charged lipid monolayers. Biochim. Biophys. Acta 467:280-289.
47. Tossi, A., M. Scocchi, B. Skerlavaj, and R. Gennaro. 1994. Identification and characterization of a primary antibacterial domain in CAP18, a lipopolysaccharide binding protein from rabbit leukocytes. FEBS Lett. 339:108-112.
48. VanderMeer, T. J., M. J. Menconi, J. Zhuang, H. Wang, R. Murtaugh, C. Bouza, P. Stevens, and M. P. Fink. 1995. Protective effects of a novel 32-amino acid C-terminal fragment of CAP18 in endotoxemic pigs. Surgery 117:656-662.
49. Waring, A. J., S. S. L. Harwig, and R. I. Lehrer. 1996. Structure and activity of protegrin-1 in model lipid membranes. Protein Peptide Lett. 3:177-184.
50. White, S. H., W. C. Wimley, and M. E. Selsted. 1995. Structure, function, and membrane integration of defensins. Curr. Opin. Struct. Biol. 5:521-527.
51. Woody, R. W. 1985. Circular dichroism of peptides, p. 15-114. In S. Udenfriend, J. Meienhofer, and V. J. Hruby (ed.), The peptides: synthesis and biology, vol. 7. Academic Press, Inc., New York, N.Y.
52. Zanetti, M., R. Gennaro, and D. Romeo. 1995. Cathelicidins: a novel protein family with a common proregion and a variable C-termmal antimicrobial domain. FEBS Lett. 374:1-5.
53. Zhao, C., T. Ganz, and R. I. Lehrer. 1995. The structure of porcine protegrin genes. FEBS Lett. 368:197-202.