Boosting innate immunity: Development and validation of a cell-based screening assay to identify LL-37 inducers

Innate Immunity

Volumn 20, Issue 4, 2014, Pages 364-376

  Nylén, Frank ^a   Miraglia, Erica ^a   Cederlund, Andreas ^a   Ottosson, Håkan ^a   Strömberg, Roger ^a   Gudmundsson, Gudmundur H ^b   Agerberth, Birgitta ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF ICELAND   (Iceland)

Author keywords

Antimicrobial peptides; CAMP gene; chemical library screening; HT 29 cell line; luciferase

Indexed keywords

CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; HISTONE DEACETYLASE INHIBITOR; ANTIMICROBIAL CATIONIC PEPTIDE; ARYLBUTYRIC ACID DERIVATIVE; BUTYRIC ACID DERIVATIVE; CAP18 LIPOPOLYSACCHARIDE-BINDING PROTEIN; MOLECULAR LIBRARY;

ARTICLE; CELL LINE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; INNATE IMMUNITY; LUCIFERASE ASSAY; PROTEIN EXPRESSION; SCREENING; STABLE TRANSFECTION; TRANSLATION INITIATION; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; EPITHELIUM CELL; FOOD AND DRUG ADMINISTRATION; GENE EXPRESSION REGULATION; GENETICS; HT 29 CELL LINE; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; MOLECULAR LIBRARY; PROCEDURES; REPORTER GENE; UNITED STATES; VALIDATION STUDY;

ANTIMICROBIAL CATIONIC PEPTIDES; BUTYRATES; DRUG DISCOVERY; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; GENES, REPORTER; HIGH-THROUGHPUT SCREENING ASSAYS; HT29 CELLS; HUMANS; IMMUNITY, INNATE; PHENYLBUTYRATES; SMALL MOLECULE LIBRARIES; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION;

EID: 84898936628     PISSN: 17534259     EISSN: 17534267     Source Type: Journal    
DOI: 10.1177/1753425913493338     Document Type: Article

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