Structure, dynamics, and antimicrobial and immune modulatory activities of human LL-23 and its single-residue variants mutated on the basis of homologous primate cathelicidins

Biochemistry

Volumn 51, Issue 2, 2012, Pages 653-664

  Wang, Guangshun ^a   Elliott, Melissa ^b   Cogen, Anna L ^c   Ezell, Edward L ^d   Gallo, Richard L ^c   Hancock, Robert E W ^b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID RESIDUES; AMPHIPATHIC; ANTI-BACTERIAL ACTIVITY; ANTI-MICROBIAL ACTIVITY; BACKBONE DYNAMICS; CATHELICIDIN; CHEMOKINES; CYTOKINES; HELICAL STRUCTURES; HETERONUCLEAR; HOST DEFENSE; HOT SPOT; HUMAN PERIPHERAL BLOOD; HYDROGEN-DEUTERIUM EXCHANGE; HYDROPHOBIC SURFACES; IMMUNE MODULATORS; LIPOPOLYSACCHARIDES; MAMMALIAN CELLS; N-TERMINALS; NATURAL PEPTIDE; NMR STRUCTURES; SECONDARY STRUCTURES; TWO DOMAINS;

AMINO ACIDS; BIOMIMETICS; DEUTERIUM; DYNAMICS; HYDROGEN; HYDROPHOBICITY; MAMMALS; MICELLES; MICROORGANISMS; PEPTIDES; POLYPEPTIDES; SURFACE CHEMISTRY;

NUCLEAR MAGNETIC RESONANCE;

ALANINE; AMINO ACID; BACTERIUM LIPOPOLYSACCHARIDE; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CYTOKINE; DIOCTANOYLPHOSPHATIDYLGLYCEROL; DODECYLPHOSPHORYLCHOLINE; GLYCEROL; SERINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VALINE;

ANTIMICROBIAL ACTIVITY; ARTICLE; DEUTERIUM HYDROGEN EXCHANGE; DRUG DESIGN; HOST RESISTANCE; HUMAN; HUMAN CELL; IMMUNOMODULATION; MAMMAL CELL; MICELLE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; ANTI-INFECTIVE AGENTS; CATHELICIDINS; CHEMOKINES; DEUTERIUM EXCHANGE MEASUREMENT; HUMANS; IMMUNOLOGIC FACTORS; LEUKOCYTES, MONONUCLEAR; MEMBRANE POTENTIALS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE FRAGMENTS; PRIMATES; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; STAPHYLOCOCCUS AUREUS;

BACTERIA (MICROORGANISMS); MAMMALIA; PRIMATES;

EID: 84862907676     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2016266     Document Type: Article

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