Antibacterial activity of the human host defence peptide LL-37 and selected synthetic cationic lipids against bacteria associated with oral and upper respiratory tract infections

Journal of Antimicrobial Chemotherapy

Volumn 68, Issue 3, 2013, Pages 610-618

  Leszczyńska, Katarzyna ^a   Namiot, Dorota ^a   Byfield, Fitzroy J ^b   Cruz, Katrina ^b   Zendzian Piotrowska, Małgorzata ^a   Fein, David E ^c   Savage, Paul B ^d   Diamond, Scott ^c   Mcculloch, Christopher A ^e   Janmey, Paul A ^b   Bucki, Robert ^b  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d Brigham Young University   (United States)

^e UNIVERSITY OF TORONTO   (Canada)

Author keywords

Ceragenins; D2S; Microbiological assay; Oral infection

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; ANTIINFECTIVE AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CERAGENIN CSA 13; CERAGENIN CSA 90; CERAGENIN CSA 92; DEXAMETHASONE DERIVATIVE; DEXAMETHASONE DERIVATIVE D2S; INTERLEUKIN 8; LACTATE DEHYDROGENASE; LIPID; PROTEINASE; SPERMINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BACTERIAL GROWTH; BACTERICIDAL ACTIVITY; CELL GROWTH; CONTROLLED STUDY; CYTOTOXICITY; ENTEROCOCCUS FAECALIS; ENZYME DEGRADATION; FIBROBLAST; FUSOBACTERIUM NUCLEATUM; HAEMOPHILUS INFLUENZAE; HELICOBACTER PYLORI; HOST RESISTANCE; HUMAN; HUMAN CELL; INFLAMMATION; INNATE IMMUNITY; KERATINOCYTE; LACTOBACILLUS CASEI; MICROBIOLOGY; MINIMUM INHIBITORY CONCENTRATION; MORAXELLA CATARRHALIS; MOUTH INFECTION; NEISSERIA MENINGITIDIS; NONHUMAN; PORPHYROMONAS GINGIVALIS; PROTEIN DEGRADATION; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STREPTOCOCCUS MUTANS; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; STREPTOCOCCUS SALIVARIUS; STREPTOCOCCUS SANGUINIS; TANNERELLA FORSYTHENSIS; UPPER RESPIRATORY TRACT INFECTION;

ADOLESCENT; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIA; HUMANS; MICROBIAL SENSITIVITY TESTS; MICROBIAL VIABILITY; MOUTH; RESPIRATORY TRACT INFECTIONS;

EID: 84873571921     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dks434     Document Type: Article

References (26)

1. Dale BA, Fredericks LP. Antimicrobial peptides in the oral environment: expression and function in health and disease. Curr Issues Mol Biol 2005; 7: 119-33.
2. Larrick JW, Hirata M, Balint RF et al. Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein. Infect Immun 1995; 63: 1291-7.
3. Leszczynska K, Namiot A, Janmey PA et al. Modulation of exogenous antibiotic activity by host cathelicidin LL-37. APMIS 2010; 118: 830-6.
4. Sandgren S, Wittrup A, Cheng F et al. The human antimicrobial peptide LL-37 transfers extracellular DNA plasmid to the nuclear compartment of mammalian cells via lipid rafts and proteoglycan-dependent endocytosis. J Biol Chem 2004; 279: 17951-6.
5. Koczulla R, von Degenfeld G, Kupatt C et al. An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J Clin Invest 2003; 111: 1665-72.
6. Lai XZ, Feng Y, Pollard J et al. Ceragenins: cholic acid-based mimics of antimicrobial peptides. Acc Chem Res 2008; 41: 1233-40.
7. Malabarba A, Ciabatti R, Kettenring J et al. Synthesis and antibacterial activity of a series of basic amides of teicoplanin and deglucoteicoplanin with polyamines. J Med Chem 1992; 35: 4054-60.
8. Isogai E, Isogai H, Takahashi K et al. Ceragenin CSA-13 exhibits antimicrobial activity against cariogenic and periodontopathic bacteria. Oral Microbiol Immunol 2009; 24: 170-2.
9. Saha S, Savage PB, Bal M. Enhancement of the efficacy of erythromycin in multiple antibiotic-resistant gram-negative bacterial pathogens. J Appl Microbiol 2008; 105: 822-8.
10. Fein DE, Limberis MP, Maloney SF et al. Cationic lipid formulations alter the in vivo tropism of AAV2/9 vector in lung. Mol Ther 2009; 17: 2078-87.
11. Bucki R, Leszczynska K, Byfield FJ et al. Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate. Antimicrob Agents Chemother 2010; 54: 2525-33.
12. Ding B, Guan Q, Walsh JP et al. Correlation of the antibacterial activities of cationic peptide antibiotics and cationic steroid antibiotics. J Med Chem 2002; 45: 663-9.
13. Leszczynska K, Namiot DB, Namiot Z et al. Application of immunoassay for detection of Helicobacter pylori antigens in the dental plaque. Adv Med Sci 2009; 54: 194-8.
14. Sieprawska-Lupa M, Mydel P, Krawczyk K et al. Degradation of human antimicrobial peptide LL-37 by Staphylococcus aureus-derived proteinases. Antimicrob Agents Chemother 2004; 48: 4673-9.
15. Saran S, Isar J, Saxena RK. A modified method for the detection of microbial proteases on agar plates using tannic acid. J Biochem Biophys Methods 2007; 70: 697-9.
16. Leszczynska K, Namiot A, Cruz K et al. Potential of ceragenin CSA-13 and its mixture with pluronic F-127 as treatment of topical bacterial infections. J Appl Microbiol 2011; 110: 229-38.
17. Oudhoff MJ, Blaauboer ME, Nazmi K et al. The role of salivary histatin and the human cathelicidin LL-37 in wound healing and innate immunity. Biol Chem 2010; 391: 541-8.
18. Aas JA, Griffen AL, Dardis SR et al. Bacteria of dental caries in primary and permanent teeth in children and young adults. J Clin Microbiol 2008; 46: 1407-17.
19. Altman H, Steinberg D, Porat Y et al. In vitro assessment of antimicrobial peptides as potential agents against several oral bacteria. J Antimicrob Chemother 2006; 58: 198-201.
20. Pettigrew MM, Gent JF, Revai K et al. Microbial interactions during upper respiratory tract infections. Emerg Infect Dis 2008; 14: 1584-91.
21. Ouhara K, Komatsuzawa H, Kawai T et al. Increased resistance to cationic antimicrobial peptide LL-37 in methicillin-resistant strains of Staphylococcus aureus. J Antimicrob Chemother 2008; 61: 1266-9.
22. Epand RF, Pollard JE, Wright JO et al. Depolarization, bacterial membrane composition, and the antimicrobial action of ceragenins. Antimicrob Agents Chemother 2010; 54: 3708-13.
23. Epand RF, Savage PB, Epand RM. Bacterial lipid composition and the antimicrobial efficacy of cationic steroid compounds (ceragenins). Biochim Biophys Acta 2007; 1768: 2500-9.
24. Shaykhiev R, Beisswenger C, Kandler K et al. Human endogenous antibiotic LL-37 stimulates airway epithelial cell proliferation and wound closure. Am J Physiol Lung Cell Mol Physiol 2005; 289: L842-8.
25. Lande R, Gregorio J, Facchinetti V et al. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 2007; 449: 564-9.
26. Bucki R, Leszczynska K, Namiot A et al. Cathelicidin LL-37: a multitask antimicrobial peptide. Arch Immunol Ther Exp (Warsz) 2010; 58: 15-25.