Antimicrobial and chemoattractant activity, lipopolysaccharide neutralization, cytotoxicity, and inhibition by serum of analogs of human cathelicidin LL-37

Antimicrobial Agents and Chemotherapy

Volumn 49, Issue 7, 2005, Pages 2845-2850

  Ciornei, Cristina D ^a,b   Sigurdardóttir, Thorgerdur ^a   Schmidtchen, Artur ^a   Bodelsson, Mikael ^a,b  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BMAP 27; CATHELICIDIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CELL DNA; CHEMOATTRACTANT; GLYCYLARGINYLPHENYLALANYLLYSYLARGINYLPHENYLALANYLARGINYLLYSYLLYSYLPHENYLALA NYLLYSYLLYSYLLEUCYLPHENYLALANYLLYSYLLYSYLLEUCYLSERYLPROLYLVALYLISOLEUCYLPROLYLLE UCYLLEUCYLHISTIDYLLEUCINAMIDE; LIPOPOLYSACCHARIDE; LYSYLLEUCYLPHENYLALANYLLYSYLARGINYLISOLEUCYLVALYLLYSYLARGINYLISOLEUCYLLEUCY LLYSYLPHENYLALANYLLEUCYLARGINYLLYSYLLEUCYLVALINE; NITRIC OXIDE; POLYMYXIN B; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG BINDING; DRUG CYTOTOXICITY; ERYTHROCYTE; ESCHERICHIA COLI; HEMOLYSIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RAT; SEPSIS; SEPTIC SHOCK; SERUM; STAPHYLOCOCCUS AUREUS; VASCULAR SMOOTH MUSCLE;

AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIA; BLOOD BACTERICIDAL ACTIVITY; CANDIDA ALBICANS; CATTLE; CHEMOTAXIS, LEUKOCYTE; HUMANS; HYDROPHOBICITY; LIPOPOLYSACCHARIDES; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEINS;

EID: 21444456146     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.49.7.2845-2850.2005     Document Type: Article

References (29)

1. Agerberth, B., J. Charo, J. Werr, B. Olsson, F. Idali, L. Lindbom, R. Kiessling, H. Jörnvall, H. Wigzell, and G. H. Gudmundsson. 2000. The human antimicrobial and chemotactic peptides LL-37 and α-defensins are expressed by specific lymphocyte and monocyte populations. Blood 96:3086-3093.
2. Ciornei, C. D., A. Egesten, and M. Bodelsson. 2003. Effects of human cathelicidin antimicrobial peptide LL-37 on lipopolysaccharide-induced nitric oxide release from rat aorta in vitro. Acta Anaesthesiol. Scand. 47:213-220.
3. Cohen, J. 2002. The immunopathogenesis of sepsis. Nature 420:885-891.
4. Fleming, I., G. A. Gray, G. Julou-Schaeffer, J. R. Parratt, and J. C. Stoclet. 1990. Incubation with endotoxin activates the L-arginine pathway in vascular tissue. Biochem. Biophys. Res. Commun. 171:562-568.
5. Fukomoto, K., I. Nagaoka, A. Yamataka, H. Kobayashi, T. Yanai, Y. Kato, and T. Miyano. 2005. Effect of antibacterial cathelicidin peptide CAP18/LL-37 on sepsis in neonatal rats. Pediatr. Surg. Int. 121:20-24.
6. Gudmundsson, G. H., B. Agerberth, J. Odeberg, T. Bergman, B. Olsson, and R. Salcedo. 1996. The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes. Eur. J. Biochem. 238:325-332.
7. Hechtman, D. H., M. I. Cybulsky, H. J. Fuchs, J. B. Baker, and M. A. Gimbrone, Jr. 1991. Intravascular IL-8. Inhibitor of polymorphonuclear leukocyte accumulation at sites of acute inflammation. J. Immunol. 147:883-892.
8. Johansson, J., G. H. Gudmundsson, M. E. Rottenberg, K. D. Berndt, and B. Agerberth. 1998. Conformation-dependent antibacterial activity of the naturally occurring human peptide LL-37. J. Biol. Chem. 273:3718-3724.
9. Kelm, M. 1999. Nitric oxide metabolism and breakdown. Biochim. Biophys. Acta 1411:273-289.
10. Larrick, J. W., M. Hirata, R. F. Balint, J. Lee, J. Zhong, and S. C. Wright. 1995. Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein. Infect. Immun. 63:1291-1297.
11. Larrick, J. W., M. Hirata, J. Zhong, and S. C. Wright. 1995. Anti-microbial activity of human CAP18 peptides. Immunotechnology 1:65-72.
12. Lehrer, R. I., M. Rosenman, S. S. S. L. Harwig, R. Jackson, and P. Eisenhauer. 1991. Ultrasensitive assays for endogenous antimicrobial polypeptides. J. Immunol. Methods 137:167-173.
13. Ley, K., J. B. Baker, M. I. Cybulsky, M. A. Gimbrone, Jr., and F. W. Luscinskas. 1993. Intravenous interleukin-8 inhibits granulocyte emigration from rabbit mesenteric venules without altering L-selectin expression or leukocyte rolling. J. Immunol. 151:6347-6357.
14. Luu, N. T., G. E. Rainger, and G. B. Nash. 2000. Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils. J. Immunol. 164:5961-5969.
15. Murakami, M., B. Lopez-Garcia, M. Braff, R. A. Dorschner, and R. L. Gallo. 2004. Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense. J. Immunol. 172:3070-3077.
16. Nagaoka, I., S. Hirota, F. Niyonsaba, M. Hirata, Y. Adachi, H. Tamura, S. Tanaka, and D. Heumann. 2002. Augmentation of the lipopolysaccharide- neutralizing activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by replacement with hydrophobic and cationic amino acid residues. Clin. Diagn. Lab. Immunol. 9:972-982.
17. Nagaoka, I., S. Hirota, S. Yomogida, A. Ohwada, and M. Hirata. 2000. Synergistic actions of antibacterial neutrophil defensins and cathelicidins. Inflamm. Res. 49:73-79.
18. Oren, Z., J. C. Lerman, G. H. Gudmundsson, B. Agerberth, and Y. Shai. 1999. Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity. Biochem. J. 341:501-513.
19. Risso, A., M. Zanetti, and R. Gennaro. 1998. Cytotoxicity and apoptosis mediated by two peptides of innate immunity. Cell. Immunol. 189:107-115.
20. Schindler, M., and M. J. Osborn. 1979. Interaction of divalent cations and polymyxin B with lipopolysaccharide. Biochemistry 18:4425-4430.
21. Scott, M. G., D. J. Davidson, M. R. Gold, D. Bowdish, and R. E. Hancock. 2002. The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses. J. Immunol. 169:3883-3891.
22. Skerlavaj, B., R. Gennaro, L. Bagella, L. Merluzzi, A. Risso, and M. Zanetti. 1996. Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities. J. Biol. Chem. 271:28375-28381.
23. Sørensen, O., K. Arnljots, J. B. Cowland, D. F. Bainton, and N. Borregaard. 1997. The human antibacterial cathelicidin, hCAP-18, is synthesized in myelocytes and metamyelocytes and localized to specific granules in neutrophils. Blood 90:2796-2803.
24. Sørensen, O., T. Bratt, A. H. Johnsen, M. T. Madsen, and N. Borregaard. 1999. The human antibacterial cathelicidin, hCAP-18, is bound to lipoproteins in plasma. J. Biol. Chem. 274:22445-22451.
25. Tavares-Murta, B. M., M. Zaparoli, R. B. Ferreira, M. L. Silva-Vergara, C. H. B. Oliveira, E. F. C. Murta, S. H. Ferreira, and F. Q. Cunha. 2002. Failure of neutrophil chemotactic function in septic patients. Crit. Care. Med. 30:1056-1061.
26. Travis, S. M., N. N. Anderson, W. R. Forsyth, C. Espiritu, B. D. Conway, E. P. Greenberg, P. B. McCray, Jr., R. I. Lehrer, M. J. Welsh, and B. F. Tack. 2000. Bactericidal activity of mammalian cathelicidin-derived peptides. Infect. Immun. 68:2748-2755.
27. Turner, J., Y. Cho, N. N. Dinh, A. J. Waring, and R. I. Lehrer. 1998. Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils. Antimicrob. Agents Chemother. 42:2206-2214.
28. Wang, Y., B. Agerberth, A. Löthgren, A. Almstedt, and J. Johansson. 1998. Apolipoprotein A-I binds and inhibits the human antibacterial/cytotoxic peptide LL-37. J. Biol. Chem. 273:33115-33118.
29. Yang, D., Q. Chen, A. P. Schmidt, G. M. Anderson, J. M. Wang, J. Wooters, J. J. Oppenheim, and O. Chertov. 2000. LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J. Exp. Med. 192:1069-1074.