Rigid nanoparticle-based delivery of anti-cancer siRNA: Challenges and opportunities

Biotechnology Advances

Volumn 32, Issue 4, 2014, Pages 831-843

  Wang, Zhiyong ^a,b   Liu, Gang ^a   Zheng, Hairong ^b   Chen, Xiaoyuan ^c  

^a XIAMEN UNIVERSITY   (China)

^b SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY   (China)

^c NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

Author keywords

Gene delivery; Gene therapy; Nanoparticles; RNA interference (RNAi); Small interfering RNA (siRNA)

Indexed keywords

CELL MEMBRANES; CYTOLOGY; GENE THERAPY; GENE TRANSFER; MEDICAL NANOTECHNOLOGY; NANOPARTICLES;

CARBON NANO-MATERIALS; CONTROLLABLE SIZE; GENE DELIVERY; HIGH SURFACE AREA; INORGANIC NANOPARTICLE; INTRACELLULAR COMPARTMENTS; RNA INTERFERENCE; SMALL INTERFERING RNA (SIRNA);

RNA;

CANCER; DISEASE TREATMENT; GENETIC ENGINEERING; NANOTECHNOLOGY; PHYSICAL PROPERTY; PROTEIN; RNA;

ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER; CALCIUM PHOSPHATE; CARBON NANOTUBE; FERRIC ION; FERRIC OXIDE; GOLD; LIGAND; NANOPARTICLE; QUANTUM DOT; SILICON DIOXIDE; SMALL INTERFERING RNA;

CELL MEMBRANE; CHEMISTRY; GENE SILENCING; GENE THERAPY; GENE TRANSFER; HUMAN; INNATE IMMUNITY; METABOLISM; NANOTECHNOLOGY; NEOPLASMS; PROCEDURES; RNA INTERFERENCE; SURFACE PROPERTY;

ANTINEOPLASTIC AGENTS; BIOLOGICAL MARKERS; CALCIUM PHOSPHATES; CELL MEMBRANE; FERRIC COMPOUNDS; GENE SILENCING; GENE TRANSFER TECHNIQUES; GENETIC THERAPY; GOLD; HUMANS; IMMUNITY, INNATE; LIGANDS; NANOPARTICLES; NANOTECHNOLOGY; NANOTUBES, CARBON; NEOPLASMS; QUANTUM DOTS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SILICON DIOXIDE; SURFACE PROPERTIES;

EID: 84901980156     PISSN: 07349750     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biotechadv.2013.08.020     Document Type: Article

References (166)

1. Ai H., Flask C., Weinberg B., Shuai X., Pagel M.D., Farrell D., et al. Magnetite-loaded polymeric micelles as ultrasensitive magnetic-resonance probes. Adv Mater 2005, 17:1949-1952.
2. Alivisatos A.P. Semiconductor clusters, nanocrystals, and quantum dots. Science 1996, 271:933-937.
3. Anderson D.C., Nichols E., Manger R., Woodle D., Barry M., Fritzberg A.R. Tumor-cell retention of antibody fab fragments is enhanced by an attached Hiv Tat protein-derived peptide. Biochem Biophys Res Commun 1993, 194:876-884.
4. Bae Y.H., Park K. Targeted drug delivery to tumors: myths, reality and possibility. J Control Release 2011, 153:198-205.
5. Bergers G., Benjamin L.E. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 2003, 3:401-410.
6. Bhattacharyya S., Kudgus R.A., Bhattacharya R., Mukherjee P. Inorganic nanoparticles in cancer therapy. Pharm Res 2011, 28:237-259.
7. Bianco A., Hoebeke J., Godefroy S., Chaloin O., Pantarotto D., Briand J.P., et al. Cationic carbon nanotubes bind to CpG oligodeoxynucleotides and enhance their immunostimulatory properties. J Am Chem Soc 2005, 127:58-59.
8. Bigall N.C., Curcio A., Leal M.P., Falqui A., Palumberi D., Di Corato R., et al. Magnetic nanocarriers with tunable pH dependence for controlled loading and release of cationic and anionic payloads. Adv Mater 2011, 23:5645-5650.
9. Cai H.C., Li Z.B., Huang C.W., Shahinian A.H., Wang H., Park R., et al. Evaluation of Copper-64 labeled AmBaSar conjugated cyclic RGD peptide for improved MicroPET imaging of integrin alpha(v)beta(3) expression. Bioconjug Chem 2010, 21:1417-1424.
10. Calzolari A., Oliviero I., Deaglio S., Mariam G., Biffoni M., Sposi N.M., et al. Transferrin receptor 2 is frequently expressed in human cancer cell lines. Blood Cells Mol Dis 2007, 39:82-91.
11. Carmeliet P., Jain R.K. Angiogenesis in cancer and other diseases. Nature 2000, 407:249-257.
12. Castro S.L., Bailey S.G., Raffaelle R.P., Banger K.K., Hepp A.F. Synthesis and characterization of colloidal CuInS2 nanoparticles from a molecular single-source precursor. J Phys Chem B 2004, 108:12429-12435.
13. Cedervall T., Lynch I., Foy M., Berggad T., Donnelly S.C., Cagney G., et al. Detailed identification of plasma proteins adsorbed on copolymer nanoparticles. Angew Chem Int Ed 2007, 46:5754-5756.
14. Chan L.W., Wang Y.N., Lin L.Y., Upton M.P., Hwang J.H., Pun S.H. Synthesis and characterization of anti-EGFR fluorescent nanoparticles for optical molecular imaging. Bioconjug Chem 2013, 24:167-175.
15. Chen Q.Z., Wong C.T., Lu W.W., Cheung K.M., Leong J.C., Luk K.D. Strengthening mechanisms of bone bonding to crystalline hydroxyapatite in vivo. Biomaterials 2004, 25:4243-4254.
16. Chen G., Chen W., Wu Z., Yuan R., Li H., Gao J., et al. MRI-visible polymeric vector bearing CD3 single chain antibody for gene delivery to T cells for immunosuppression. Biomaterials 2009, 30:1962-1970.
17. Cheng Z.L., Al Zaki A., Hui J.Z., Muzykantov V.R., Tsourkas A. Multifunctional nanoparticles: cost versus benefit of adding targeting and imaging capabilities. Science 2012, 338:903-910.
18. Cheung W., Pontoriero F., Taratula O., Chen A.M., He H.X. DNA and carbon nanotubes as medicine. Adv Drug Deliv Rev 2010, 62:633-649.
19. Chiu Y.L., Ali A., Chu C.Y., Cao H., Rana T.M. Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells. Chem Biol 2004, 11:1165-1175.
20. Cho K.J., Wang X., Nie S.M., Chen Z., Shin D.M. Therapeutic nanoparticles for drug delivery in cancer. Clin Cancer Res 2008, 14:1310-1316.
21. Collnot E.M., Baldes C., Wempe M.F., Hyatt J., Navarro L., Edgar K.J., et al. Influence of vitamin E TPGS poly(ethylene glycol) chain length on apical. efflux transporters in Caco-2 cell monolayers. J Control Release 2006, 111:35-40.
22. Crow D.M., Williams L., Colcher D., Wong J.Y.C., Raubitschek A., Shively J.E. Combined radioimmunotherapy and chemotherapy of breast tumors with Y-90-labeled anti-Her2 and anti-CEA antibodies with Taxol. Bioconjug Chem 2005, 16:1117-1125.
23. Curcio A., Marotta R., Riedinger A., Palumberi D., Falqui A., Pellegrino T. Magnetic pH-responsive nanogels as multifunctional delivery tools for small interfering RNA (siRNA) molecules and iron oxide nanoparticles (IONPs). Chem Commun 2012, 48:2400-2402.
24. Danhier F., Feron O., Preat V. To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery. J Control Release 2010, 148:135-146.
25. de Fougerolles A., Vornlocher H.P., Maraganore J., Lieberman J. Interfering with disease: a progress report on siRNA-based therapeutics. Nat Rev Drug Discov 2007, 6:443-453.
26. del Pino P., Munoz-Javier A., Vlaskou D., Rivera Gil P., Plank C., Parak W.J. Gene silencing mediated by magnetic lipospheres tagged with small interfering RNA. Nano Lett 2010, 10:3914-3921.
27. DeLong R.K., Akhtar U., Sallee M., Parker B., Barber S., Zhang J., et al. Characterization and performance of nucleic acid nanoparticles combined with protamine and gold. Biomaterials 2009, 30:6451-6459.
28. Derfus A.M., Chen A.A., Min D.H., Ruoslahti E., Bhatia S.N. Targeted quantum dot conjugates for siRNA delivery. Bioconjug Chem 2007, 18:1391-1396.
29. Desgrosellier J.S., Cheresh D.A. Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer 2010, 10:9-22.
30. Dufes C., Uchegbu I.F., Schatzlein A.G. Dendrimers in gene delivery. Adv Drug Deliv Rev 2005, 57:2177-2202.
31. Edelstein M.L., Abedi M.R., Wixon J. Gene therapy clinical trials worldwide to 2007 - an update. J Gene Med 2007, 9:833-842.
32. Elbakry A., Zaky A., Liebkl R., Rachel R., Goepferich A., Breunig M. Layer-by-layer assembled gold nanoparticles for siRNA delivery. Nano Lett 2009, 9:2059-2064.
33. Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001, 411:494-498.
34. Elias D.R., Poloukhtine A., Popik V., Tsourkas A. Effect of ligand density, receptor density, and nanoparticle size on cell targeting. Nanomedicine: NBM 2013, 9:194-201.
35. Ferrara N., Hillan K.J., Novotny W. Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy. Biochem Biophys Res Commun 2005, 333:328-335.
36. Fire A., Xu S.Q., Montgomery M.K., Kostas S.A., Driver S.E., Mello C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998, 391:806-811.
37. Fonseca S.B., Pereira M.P., Kelley S.O. Recent advances in the use of cell-penetrating peptides for medical and biological applications. Adv Drug Deliv Rev 2009, 61:953-964.
38. Frank P.G., Marcel Y.L. Apolipoprotein A-I: structure-function relationships. J Lipid Res 2000, 41:853-872.
39. Gao X.H., Cui Y.Y., Levenson R.M., Chung L.W.K., Nie S.M. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat Biotechnol 2004, 22:969-976.
40. Gao J., Liu W., Xia Y., Li W., Sun J., Chen H.W., et al. The promotion of siRNA delivery to breast cancer overexpressing epidermal growth factor receptor through anti-EGFR antibody conjugation by immunoliposomes. Biomaterials 2011, 32:3459-3470.
41. Gao J.H., Chen K., Miao Z., Ren G., Chen X.Y., Gambhir S.S., et al. Affibody-based nanoprobes for HER2-expressing cell and tumor imaging. Biomaterials 2011, 32:2141-2148.
42. Gao L., Xie L., Long X., Wang Z., He C.-Y., Chen Z.-Y., et al. Efficacy of MRI visible iron oxide nanoparticles in delivering minicircle DNA into liver via intrabiliary infusion. Biomaterials 2013, 34:3688-3696.
43. Gatter K.C., Brown G., Trowbridge I.S., Woolston R.E., Mason D.Y. Transferrin receptors in human-tissues - Their distribution and possible clinical relevance. J Clin Pathol 1983, 36:539-545.
44. Hashida M., Mahato R.I., Kawabata K., Miyao T., Nishikawa M., Takakura Y. Pharmacokinetics and targeted delivery of proteins and genes. J Control Release 1996, 41:91-97.
45. Heine M., Freund B., Nielsen P., Jung C., Reimer R., Hohenberg H., et al. High interstitial fluid pressure is associated with low tumour penetration of diagnostic monoclonal antibodies applied for molecular imaging purposes. PLoS One 2012, 7:e36258.
46. Heldin C.H., Rubin K., Pietras K., Ostman A. High interstitial fluid pressure - An obstacle in cancer therapy. Nat Rev Cancer 2004, 4:806-813.
47. Hellstrand E., Lynch I., Andersson A., Drakenberg T., Dahlback B., Dawson K.A., et al. Complete high-density lipoproteins in nanoparticle corona. FEBS J 2009, 276:3372-3381.
48. Herbst R.S., Shin D.M. Monoclonal antibodies to target epidermal growth factor receptor-positive tumors - A new paradigm for cancer therapy. Cancer 2002, 94:1593-1611.
49. Hill E., Shukla R., Park S.S., Baker J.R. Synthetic PAMAM-RGD conjugates target and bind to odontoblast-like MDPC 23 cells and the predentin in tooth organ cultures. Bioconjug Chem 2007, 18:1756-1762.
50. Hom C., Lu J., Liong M., Luo H.Z., Li Z.X., Zink J.I., et al. Mesoporous silica nanoparticles facilitate delivery of siRNA to shutdown signaling pathways in mammalian cells. Small 2010, 6:1185-1190.
51. Huang X.H., Peng X.H., Wang Y.Q., Wang Y.X., Shin D.M., El-Sayed M.A., et al. A reexamination of active and passive tumor targeting by using rod-shaped gold nanocrystals and covalently conjugated peptide ligands. ACS Nano 2010, 4:5887-5896.
52. Ishida T., Ichihara M., Wang X., Yamamoto K., Kimura J., Majima E., et al. Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes. J Control Release 2006, 112:15-25.
53. Iversen T.G., Skotland T., Sandvig K. Endocytosis and intracellular transport of nanoparticles: present knowledge and need for future studies. Nano Today 2011, 6:176-185.
54. Janssen M., Oyen W.J.G., Massuger L.F.A.G., Frielink C., Dijkgraaf I., Edwards D.S., et al. Comparison of a monomeric and dimeric radiolabeled RGD-peptide for tumor targeting. Cancer Biother Radiopharm 2002, 17:641-646.
55. Jiang W., Kim B.Y.S., Rutka J.T., Chan W.C.W. Nanoparticle-mediated cellular response is size-dependent. Nat Nanotechnol 2008, 3:145-150.
56. Jiang X.M., Wang L.M., Wang J., Chen C.Y. Gold nanomaterials: preparation, chemical modification, biomedical applications and potential risk assessment. Appl Biochem Biotechnol 2012, 166:1533-1551.
57. Jordan M., Schallhorn A., Wurm F.M. Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation. Nucleic Acids Res 1996, 24:596-601.
58. Kakizawa Y., Furukawa S., Kataoka K. Block copolymer-coated calcium phosphate nanoparticles sensing intracellular environment for oligodeoxynucleotide and siRNA delivery. J Control Release 2004, 97:345-356.
59. Kano M.R., Bae Y., Iwata C., Morishita Y., Yashiro M., Oka M., et al. Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling. Proc Natl Acad Sci U S A 2007, 104:3460-3465.
60. Ke C.Y., Mathias C.J., Green M.A. Targeting the tumor-associated folate receptor with an In-111-DTPA conjugate of pteroic acid. J Am Chem Soc 2005, 127:7421-7426.
61. Kievit F.M., Zhang M.Q. Cancer nanotheranostics: improving imaging and therapy by targeted delivery across biological barriers. Adv Mater 2011, 23:H217-H247.
62. Kievit F.M., Veiseh O., Bhattarai N., Fang C., Gunn J.W., Lee D., et al. PEI-PEG-chitosan-copolymer-coated iron oxide nanoparticles for safe gene delivery: synthesis, complexation, and transfection. Adv Funct Mater 2009, 19:2244-2251.
63. Kim S.H., Jeong J.H., Lee S.H., Kim S.W., Park T.G. PEG conjugated VEGF siRNA for anti-angiogenic gene therapy. J Control Release 2006, 116:123-129.
64. Kim S.T., Chompoosor A., Yeh Y.C., Agasti S.S., Solfiell D.J., Rotello V.M. Dendronized gold nanoparticles for siRNA delivery. Small 2012, 8:3253-3256.
65. Klein S., Zolk O., Fromm M.F., Schrodl F., Neuhuber W., Kryschi C. Functionalized silicon quantum dots tailored for targeted siRNA delivery. Biochem Biophys Res Commun 2009, 387:164-168.
66. Knipe J.M., Peters J.T., Peppas N.A. Theranostic agents for intracellular gene delivery with spatiotemporal imaging. Nano Today 2013, 8:21-38.
67. Kuenen B., Witteveen P.O., Ruijter R., Giaccone G., Dontabhaktuni A., Fox F., et al. A Phase I pharmacologic study of Necitumumab (IMC-11F8), a fully human IgG(1) monoclonal antibody directed against EGFR in patients with advanced solid malignancies. Clin Cancer Res 2010, 16:1915-1923.
68. Kwon Y.J. Before and after endosomal escape: roles of stimuli-converting siRNA/polymer interactions in determining gene silencing efficiency. Acc Chem Res 2012, 45:1077-1088.
69. Kwon I.K., Lee S.C., Han B., Park K. Analysis on the current status of targeted drug delivery to tumors. J Control Release 2012, 164:108-114.
70. Law W.C., Mahajan S.D., Kopwitthaya A., Reynolds J.L., Liu M.X., Liu X., et al. Gene silencing of human neuronal cells for drug addiction therapy using anisotropic nanocrystals. Theranostics 2012, 2:695-704.
71. Layzer J.M., McCaffrey A.P., Tanner A.K., Huang Z., Kay M.A., Sullenger B.A. In vivo activity of nuclease-resistant siRNAs. RNA 2004, 10:766-771.
72. Lee S.H., Bae K.H., Kim S.H., Lee K.R., Park T.G. Amine-functionalized gold nanoparticles as non-cytotoxic and efficient intracellular siRNA delivery carriers. Int J Pharm 2008, 364:94-101.
73. Lee S.K., Han M.S., Asokan S., Tung C.H. Effective gene silencing by multilayered siRNA-coated gold nanoparticles. Small 2011, 7:364-370.
74. Li S.D., Huang L. Nanoparticles evading the reticuloendothelial system: role of the supported bilayer. BBA-Biomembranes 2009, 1788:2259-2266.
75. Li S.D., Huang L. Stealth nanoparticles: high density but sheddable PEG is a key for tumor targeting. J Control Release 2010, 145:178-181.
76. Li W.J., Szoka F.C. Lipid-based nanoparticles for nucleic acid delivery. Pharm Res 2007, 24:438-449.
77. Li J., Chen Y.C., Tseng Y.C., Mozumdar S., Huang L. Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery. J Control Release 2010, 142:416-421.
78. Li J.M., Zhao M.X., Su H., Wang Y.Y., Tan C.P., Ji L.N., et al. Multifunctional quantum-dot-based siRNA delivery for HPV18 E6 gene silence and intracellular imaging. Biomaterials 2011, 32:7978-7987.
79. Liu Z., Winters M., Holodniy M., Dai H.J. siRNA delivery into human T cells and primary cells with carbon-nanotube transporters. Angew Chem Int Ed 2007, 46:2023-2027.
80. Liu Z.F., Yan Y.J., Chin F.T., Wang F., Chen X.Y. Dual integrin and gastrin-releasing peptide receptor targeted tumor imaging using F-18-labeled PEGylated RGD-Bombesin Heterodimer F-18-FB-PEG(3)-Glu-RGD-BBN. J Med Chem 2009, 52:425-432.
81. Liu Z.F., Yan Y.J., Liu S.L., Wang F., Chen X.Y. F-18, Cu-64, and Ga-68 labeled RGD-Bombesin heterodimeric peptides for PET imaging of breast cancer. Bioconjug Chem 2009, 20:1016-1025.
82. Liu G., Wang Z.Y., Lu J., Xia C.C., Gao F.B., Gong Q.Y., et al. Low molecular weight alkyl-polycation wrapped magnetite nanoparticle clusters as MRI probes for stem cell labeling and in vivo imaging. Biomaterials 2011, 32:528-537.
83. Liu G., Xie J., Zhang F., Wang Z., Luo K., Zhu L., et al. N-Alkyl-PEI-functionalized iron oxide nanoclusters for efficient siRNA delivery. Small 2011, 7:2742-2749.
84. Liu Y., Chen Z., Liu C., Yu D., Lu Z., Zhang N. Gadolinium-loaded polymeric nanoparticles modified with anti-VEGF as multifunctional MRI contrast agents for the diagnosis of liver cancer. Biomaterials 2011, 32:5167-5176.
85. Liu G., Choi K.Y., Bhirde A., Swierczewska M., Yin J., Lee S.W., et al. Sticky nanoparticles: a platform for siRNA delivery by a Bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate. Angew Chem Int Ed 2012, 51:445-449.
86. Luo D., Saltzman W.M. Synthetic DNA delivery systems. Nat Biotechnol 2000, 18:33-37.
87. Lynch I., Salvati A., Dawson K.A. Protein-nanoparticle interactions what does the cell see?. Nat Nanotechnol 2009, 4:546-547.
88. Maeda H. The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. Adv Enzyme Regul 2001, 41:189-207.
89. Malam Y., Loizidou M., Seifalian A.M. Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer. Trends Pharmacol Sci 2009, 30:592-599.
90. Massoud T.F., Gambhir S.S. Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Gene Dev 2003, 17:545-580.
91. Matsumura Y., Maeda H. A new concept for macromolecular therapeutics in cancer-chemotherapy - Mechanism of tumoritropic accumulation of proteins and the antitumor agent Smancs. Cancer Res 1986, 46:6387-6392.
92. Meng H.A., Liong M., Xia T.A., Li Z.X., Ji Z.X., Zink J.I., et al. Engineered design of mesoporous silica nanoparticles to deliver doxorubicin and P-Glycoprotein siRNA to overcome drug resistance in a cancer cell line. ACS Nano 2010, 4:4539-4550.
93. Mickler F.M., Mockl L., Ruthardt N., Ogris M., Wagner E., Brauchle C. Tuning nanoparticle uptake: live-cell imaging reveals two distinct endocytosis mechanisms mediated by natural and artificial EGFR targeting ligand. Nano Lett 2012, 12:3417-3423.
94. Milosevic A., Fyles A., Hedley D., Hill R. The human tumor microenvironment: Invasive (needle) measurement of oxygen and interstitial fluid pressure. Semin Radiat Oncol 2004, 14:249-258.
95. Mintzer M.A., Simanek E.E. Nonviral vectors for gene delivery. Chem Rev 2009, 109:259-302.
96. Miyano T., Wijagkanalan W., Kawakami S., Yamashita F., Hashida M. Anionic amino acid dendrimer-trastuzumab conjugates for specific internalization in HER2-positive cancer cells. Mol Pharm 2010, 7:1318-1327.
97. Moghimi S.M., Hunter A.C., Murray J.C. Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol Rev 2001, 53:283-318.
98. Mok H., Veiseh O., Fang C., Kievit F.M., Wang F.Y., Park J.O., et al. pH-Sensitive siRNA nanovector for targeted gene silencing and cytotoxic effect in cancer cells. Mol Pharm 2010, 7:1930-1939.
99. Moret I., Peris J.E., Guillem V.M., Benet M., Revert F., Dasi F., et al. Stability of PEI-DNA and DOTAP-DNA complexes: effect of alkaline pH, heparin and serum. J Control Release 2001, 76:169-181.
100. Nair P. Epidermal growth factor receptor family and its role in cancer progression. Curr Sci India 2005, 88:890-898.
101. Nel A.E., Madler L., Velegol D., Xia T., Hoek E.M.V., Somasundaran P., et al. Understanding biophysicochemical interactions at the nano-bio interface. Nat Mater 2009, 8:543-557.
102. Nukolova N.V., Oberoi H.S., Cohen S.M., Kabanov A.V., Bronich T.K. Folate-decorated nanogels for targeted therapy of ovarian cancer. Biomaterials 2011, 32:5417-5426.
103. Oh Y.K., Park T.G. siRNA delivery systems for cancer treatment. Adv Drug Deliv Rev 2009, 61:850-862.
104. Ohkuma S., Poole B. Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents. Proc Natl Acad Sci U S A 1978, 75:3327-3331.
105. Okuda T., Niidome T., Aoyagi H. Cytosolic soluble proteins induce DNA release from DNA-gene carrier complexes. J Control Release 2004, 98:325-332.
106. Ouyang D., Zhang H., Herten D.P., Parekh H.S., Smith S.C. Structure, dynamics, and energetics of siRNA-cationic vector complexation: a molecular dynamics study. J Phys Chem B 2010, 114:9220-9230.
107. Pantarotto D., Singh R., McCarthy D., Erhardt M., Briand J.P., Prato M., et al. Functionalized carbon nanotubes for plasmid DNA gene delivery. Angew Chem Int Ed 2004, 43:5242-5246.
108. Park T.G., Jeong J.H., Kim S.W. Current status of polymeric gene delivery systems. Adv Drug Deliv Rev 2006, 58:467-486.
109. Parker N., Turk M.J., Westrick E., Lewis J.D., Low P.S., Leamon C.P. Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay. Anal Biochem 2005, 338:284-293.
110. Pinto O.A., Tabaković A., Goff T.M., Liu Y., Adair J.H. Calcium Phosphate and Calcium Phosphosilicate Mediated Drug Delivery and Imaging. Intracellular delivery 2011, 713-744. Springer, Netherlands. A. Prokop (Ed.).
111. Pittella F., Zhang M., Lee Y., Kim H.J., Tockary T., Osada K., et al. Enhanced endosomal escape of siRNA-incorporating hybrid nanoparticles from calcium phosphate and PEG-block charge-conversional polymer for efficient gene knockdown with negligible cytotoxicity. Biomaterials 2011, 32:3106-3114.
112. Pouton C.W., Seymour L.W. Key issues in non-viral gene delivery. Adv Drug Deliv Rev 2001, 46:187-203.
113. Rangavittal N., Landa-Canovas A.R., Gonzalez-Calbet J.M., Vallet-Regi M. Structural study and stability of hydroxyapatite and beta-tricalcium phosphate: two important bioceramics. J Biomed Mater Res 2000, 51:660-668.
114. Rehder D.S., Chelius D., McAuley A., Dillon T.M., Xiao G., Crouse-Zeineddini J., et al. Isomerization of a single aspartyl residue of anti-epidermal growth factor receptor immunoglobulin gamma 2 antibody highlights the role avidity plays in antibody activity. Biochemistry-Us 2008, 47:2518-2530.
115. Rejman J., Bragonzi A., Conese M. Role of clathrin- and caveolae-mediated endocytosis in gene transfer mediated by lipo- and polyplexes. Mol Ther 2005, 12:468-474.
116. Rikans L.E., Yamano T. Mechanisms of cadmium-mediated acute hepatotoxicity. J Biochem Mol Toxicol 2000, 14:110-117.
117. Rocker C., Potzl M., Zhang F., Parak W.J., Nienhaus G.U. A quantitative fluorescence study of protein monolayer formation on colloidal nanoparticles. Nat Nanotechnol 2009, 4:577-580.
118. Ruan J., Song H., Qian Q.R., Li C., Wang K., Bao C.C., et al. HER2 monoclonal antibody conjugated RNase-A-associated CdTe quantum dots for targeted imaging and therapy of gastric cancer. Biomaterials 2012, 33:7093-7102.
119. Sah D.W.Y. Therapeutic potential of RNA interference for neurological disorders. Life Sci 2006, 79:1773-1780.
120. Salvati A., Pitek A.S., Monopoli M.P., Prapainop K., Bombelli F.B., Hristov D.R., et al. Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface. Nat Nanotechnol 2013, 8:137-143.
121. Santra S., Yang H., Stanley J.T., Holloway P.H., Moudgil B.M., Walter G., et al. Rapid and effective labeling of brain tissue using TAT-conjugated CdS: Mn/ZnS quantum dots. Chem Commun 2005, 3144-3146.
122. Saul J.M., Annapragada A.V., Bellamkonda R.V. A dual-ligand approach for enhancing targeting selectivity of therapeutic nanocarriers. J Control Release 2006, 114:277-287.
123. Scherphof G.L., Kamps J.A.A.M. The role of hepatocytes in the clearance of liposomes from the blood circulation. Prog Lipid Res 2001, 40:149-166.
124. Seok J., Warren H.S., Cuenca A.G., Mindrinos M.N., Baker H.V., Xu W., et al. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A 2013, 110:3507-3512.
125. Seth S., Johns R., Templin M.V. Delivery and biodistribution of siRNA for cancer therapy: challenges and future prospects. Ther Deliv 2012, 3:245-261.
126. Shim M.S., Kim C.S., Ahn Y.C., Chen Z.P., Kwon Y.J. Combined multimodal optical imaging and targeted gene silencing using stimuli-transforming nanotheragnostics. J Am Chem Soc 2010, 132:8316-8324.
127. Shubayev V.I., Pisanic T.R., Jin S. Magnetic nanoparticles for theragnostics. Adv Drug Deliv Rev 2009, 61:467-477.
128. Singh R., Pantarotto D., McCarthy D., Chaloin O., Hoebeke J., Partidos C.D., et al. Binding and condensation of plasmid DNA onto functionalized carbon nanotubes: toward the construction of nanotube-based gene delivery vectors. J Am Chem Soc 2005, 127:4388-4396.
129. Singh N., Agrawal A., Leung A.K.L., Sharp P.A., Bhatia S.N. Effect of nanoparticle conjugation on gene silencing by RNA interference. J Am Chem Soc 2010, 132:8241-8243.
130. Song W.J., Du J.Z., Sun T.M., Zhang P.Z., Wang J. Gold nanoparticles capped with polyethyleneimine for enhanced siRNA delivery. Small 2010, 6:239-246.
131. Stark W.J. Nanoparticles in biological systems. Angew Chem Int Ed 2011, 50:1242-1258.
132. Stefanick J.F., Ashley J.D., Kiziltepe T., Bilgicer B. A systematic analysis of peptide linker length and liposomal polyethylene glycol coating on cellular uptake of peptide-targeted liposomes. ACS Nano 2013, 7:2935-2947.
133. Stefanou D., Batistatou A., Arkoumani E., Ntzani E., Agnantis N.J. Expression of vascular endothelial growth factor (VEGF) and association with microvessel density in small-cell and non-small-cell lung carcinomas. Histol Histopathol 2004, 19:37-42.
134. Subramaniam P., Lee S.J., Shah S., Patel S., Starovoytov V., Lee K.B. Generation of a library of non-toxic quantum dots for cellular imaging and siRNA delivery. Adv Mater 2012, 24:4014-4019.
135. Sugahara K.N., Teesalu T., Karmali P.P., Kotamraju V.R., Agemy L., Greenwald D.R., et al. Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs. Science 2010, 328:1031-1035.
136. Sun S., Zeng H., Robinson D.B., Raoux S., Rice P.M., Wang S.X., et al. Monodisperse MFe2O4 (M=Fe, Co, Mn) nanoparticles. J Am Chem Soc 2004, 126:273-279.
137. Taratula O., Garbuzenko O., Savla R., Wang Y.A., He H., Minko T. Multifunctional nanomedicine platform for cancer specific delivery of siRNA by superparamagnetic iron oxide nanoparticles-dendrimer complexes. Curr Drug Deliv 2011, 8:59-69.
138. Torchilin V.P. Drug targeting. Eur J Pharm Sci 2000, 11:S81-S91.
139. Torimoto T., Adachi T., Okazaki K., Sakuraoka M., Shibayama T., Ohtani B., et al. Facile synthesis of ZnS-AgInS2 solid solution nanoparticles for a color-adjustable luminophore. J Am Chem Soc 2007, 129:12388-12389.
140. Valencia P.M., Hanewich-Hollatz M.H., Gao W.W., Karim F., Langer R., Karnik R., et al. Effects of ligands with different water solubilities on self-assembly and properties of targeted nanoparticles. Biomaterials 2011, 32:6226-6233.
141. van Rooy I., Mastrobattista E., Storm G., Hennink W.E., Schiffelers R.M. Comparison of five different targeting ligands to enhance accumulation of liposomes into the brain. J Control Release 2011, 150:30-36.
142. Veiseh O., Kievit F.M., Fang C., Mu N., Jana S., Leung M.C., et al. Chlorotoxin bound magnetic nanovector tailored for cancer cell targeting, imaging, and siRNA delivery. Biomaterials 2010, 31:8032-8042.
143. Veiseh O., Kievit F.M., Mok H., Ayesh J., Clark C., Fang C., et al. Cell transcytosing poly-arginine coated magnetic nanovector for safe and effective siRNA delivery. Biomaterials 2011, 32:5717-5725.
144. Walczyk D., Bombelli F.B., Monopoli M.P., Lynch I., Dawson K.A. What the cell "sees" in bionanoscience. J Am Chem Soc 2010, 132:5761-5768.
145. Wan Q., Xie L., Gao L., Wang Z., Nan X., Lei H., et al. Self-assembled magnetic theranostic nanoparticles for highly sensitive MRI of minicircle DNA delivery. Nanoscale 2013, 5:744-752.
146. Wang Z.Y., Liu G., Sun J., Wu B.Y., Gong Q.Y., Song B., et al. Self-assembly of magnetite nanocrystals with amphiphilic polyethylenimine: structures and applications in magnetic resonance imaging. J Nanosci Nanotechnol 2009, 9:378-385.
147. Wang Z., Liu G., Sun J., Gong Q., Song B., Ai H., et al. N-alkyl-polyethylenimine stabilized iron oxide nanoparticles as MRI visible transfection agents. J Nanosci Nanotechnol 2012, 12:879-886.
148. Watson P., Jones A.T., Stephens D.J. Intracellular trafficking pathways and drug delivery: fluorescence imaging of living and fixed cells. Adv Drug Deliv Rev 2005, 57:43-61.
149. Werner M.E., Karve S., Sukumar R., Cummings N.D., Copp J.A., Chen R.C., et al. Folate-targeted nanoparticle delivery of chemo- and radiotherapeutics for the treatment of ovarian cancer peritoneal metastasis. Biomaterials 2011, 32:8548-8554.
150. Willis M.C., Collins B.D., Zhang T., Green L.S., Sebesta D.P., Bell C., et al. Liposome-anchored vascular endothelial growth factor aptamers. Bioconjug Chem 1998, 9:573-582.
151. Woods N.B., Bottero V., Schmidt M., von Kalle C., Verma I.M. Gene therapy: therapeutic gene causing lymphoma. Nature 2006, 440:1123.
152. Xia T.A., Kovochich M., Liong M., Meng H., Kabehie S., George S., et al. Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs. ACS Nano 2009, 3:3273-3286.
153. Xing R.J., Liu G., Quan Q.M., Bhirde A., Zhang G.F., Jin A., et al. Functional MnO nanoclusters for efficient siRNA delivery. Chem Commun 2011, 47:12152-12154.
154. Xu Y.H., Szoka F.C. Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection. Biochemistry-Us 1996, 35:5616-5623.
155. Xu Z.P., Zeng Q.H., Lu G.Q., Yu A.B. Inorganic nanoparticles as carriers for efficient cellular delivery. Chem Eng Sci 2006, 61:1027-1040.
156. Yamaoka T., Tabata Y., Ikada Y. Distribution and tissue uptake of poly(ethylene glycol) with different molecular-weights after intravenous administration to mice. J Pharm Sci 1994, 83:601-606.
157. Yang Y., Hu Y.X., Wang Y.H., Li J., Liu F., Huang L. Nanoparticle delivery of pooled siRNA for effective treatment of non-small cell lung cancer. Mol Pharm 2012, 9:2280-2289.
158. Yip W.L., Weyergang A., Berg K., Tonnesen H.H., Selbo P.K. Targeted delivery and enhanced cytotoxicity of cetuximab-saporin by photochemical internalization in EGFR-positive cancer cells. Mol Pharm 2007, 4:241-251.
159. Zelphati O., Szoka F.C. Mechanism of oligonucleotide release from cationic liposomes. Proc Natl Acad Sci U S A 1996, 93:11493-11498.
160. Zhang L.W., Monteiro-Riviere N.A. Mechanisms of quantum dot nanoparticle cellular uptake. Toxicol Sci 2009, 110:138-155.
161. Zhang Y., Wang T.H. Quantum dot enabled molecular sensing and diagnostics. Theranostics 2012, 2:631-654.
162. Zhang T.T., Stilwell J.L., Gerion D., Ding L.H., Elboudwarej O., Cooke P.A., et al. Cellular effect of high doses of silica-coated quantum dot profiled with high throughput gene expression analysis and high content cellomics measurements. Nano Lett 2006, 6:800-808.
163. Zhang C., Gao S.J., Jiang W., Lin S., Du F.S., Li Z.C., et al. Targeted minicircle DNA delivery using folate-poly(ethylene glycol)-polyethylenimine as non-viral carrier. Biomaterials 2010, 31:6075-6086.
164. Zhang H.Y., Lee M.Y., Hogg M.G., Dordick J.S., Sharfstein S.T. Gene delivery in three-dimensional cell cultures by superparamagnetic nanoparticles. ACS Nano 2010, 4:4733-4743.
165. Zhang L.Y., Wang T.T., Li L., Wang C.G., Su Z.M., Li J. Multifunctional fluorescent-magnetic polyethyleneimine functionalized Fe3O4-mesoporous silica yolk-shell nanocapsules for siRNA delivery. Chem Commun 2012, 48:8706-8708.
166. Zhang Z.J., Wang J., Chen C.Y. Gold nanorods based platforms for light-mediated theranostics. Theranostics 2013, 3:223-238.