Influence of vitamin E TPGS poly(ethylene glycol) chain length on apical efflux transporters in Caco-2 cell monolayers

Journal of Controlled Release

Volumn 111, Issue 1-2, 2006, Pages 35-40

  Collnot, Eva Maria ^a   Baldes, Christiane ^a   Wempe, Michael F ^b   Hyatt, John ^b   Navarro, Lisa ^b   Edgar, Kevin J ^b   Schaefer, Ulrich Friedrich ^a   Lehr, Claus Michael ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b EASTMAN CHEMICAL COMPANY   (United States)

Author keywords

Absorption enhancer; Caco 2; P glycoprotein; Poly(ethylene glycol); Vitamin E TPGS

Indexed keywords

ABSORPTION; DRUG PRODUCTS; MONOLAYERS; POLYETHYLENE GLYCOLS; PROTEINS; SURFACE ACTIVE AGENTS;

ABSORPTION ENHANCER; CACO-2; P-GLYCOPROTEIN; POLY(ETHYLENE GLYCOL); VITAMIN E TPGS;

VITAMINS;

ALKYL GROUP; ALPHA TOCOPHEROL DERIVATIVE; ALPHA TOCOPHEROL POLYETHYLENE GLYCOL 200 SUCCINATE; ALPHA TOCOPHEROL POLYETHYLENE GLYCOL 2000 SUCCINATE; ALPHA TOCOPHEROL POLYETHYLENE GLYCOL 238 SUCCINATE; ALPHA TOCOPHEROL POLYETHYLENE GLYCOL 3400 SUCCINATE; ALPHA TOCOPHEROL POLYETHYLENE GLYCOL 3500 SUCCINATE; ALPHA TOCOPHEROL POLYETHYLENE GLYCOL 400 SUCCINATE; ALPHA TOCOPHEROL POLYETHYLENE GLYCOL 4000 SUCCINATE; ALPHA TOCOPHEROL POLYETHYLENE GLYCOL 600 SUCCINATE; ALPHA TOCOPHEROL POLYETHYLENE GLYCOL 6000 SUCCINATE; ALPHA TOCOPHEROL SUCCINATE; EMULSIFYING AGENT; GLYCOPROTEIN P; GLYCOPROTEIN P INHIBITOR; LIPID; RHODAMINE 123; SOLUBILIZER; SURFACTANT; TOCOFERSOLAN; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; CYTOTOXICITY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG FORMULATION; DRUG SOLUBILITY; DRUG SYNTHESIS; DRUG TRANSPORT; HUMAN; HUMAN CELL; HYDROPHILICITY; LIPOPHILICITY; PRIORITY JOURNAL;

ANALYSIS OF VARIANCE; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MOLECULAR STRUCTURE; POLYETHYLENE GLYCOLS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RHODAMINE 123; VITAMIN E;

EID: 33344459216     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2005.11.005     Document Type: Article

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