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Volumn 7, Issue 4, 2013, Pages 2935-2947

A systematic analysis of peptide linker length and liposomal polyethylene glycol coating on cellular uptake of peptide-targeted liposomes

Author keywords

cellular uptake; HER2; ligand targeted liposome; peptide linker; peptide targeted liposome; polyethylene glycol; VLA 4

Indexed keywords

CELLULAR UPTAKE; CONTROLLED STOICHIOMETRY; HER2; LIPOSOMAL NANOPARTICLES; PEGYLATED LIPOSOMES; PEPTIDE LINKERS; SYNTHETIC STRATEGIES; VLA-4;

EID: 84876557641     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn305663e     Document Type: Article
Times cited : (179)

References (60)
  • 1
    • 70350292588 scopus 로고    scopus 로고
    • Liposomes and Nanoparticles: Nanosized Vehicles for Drug Delivery in Cancer
    • Malam, Y.; Loizidou, M.; Seifalian, A. M. Liposomes and Nanoparticles: Nanosized Vehicles for Drug Delivery in Cancer Trends Pharmacol. Sci. 2009, 30, 592-599
    • (2009) Trends Pharmacol. Sci. , vol.30 , pp. 592-599
    • Malam, Y.1    Loizidou, M.2    Seifalian, A.M.3
  • 3
    • 24644437854 scopus 로고    scopus 로고
    • Ligand-Targeted Liposomes for Cancer Treatment
    • Sapra, P.; Tyagi, P.; Allen, T. M. Ligand-Targeted Liposomes for Cancer Treatment Curr. Drug Delivery 2005, 2, 369-381
    • (2005) Curr. Drug Delivery , vol.2 , pp. 369-381
    • Sapra, P.1    Tyagi, P.2    Allen, T.M.3
  • 4
    • 34548482374 scopus 로고    scopus 로고
    • Stealth Liposomes: Review of the Basic Science, Rationale, and Clinical Applications, Existing and Potential
    • Immordino, M. L.; Dosio, F.; Cattel, L. Stealth Liposomes: Review of the Basic Science, Rationale, and Clinical Applications, Existing and Potential Int. J. Nanomed. 2006, 1, 297-315
    • (2006) Int. J. Nanomed. , vol.1 , pp. 297-315
    • Immordino, M.L.1    Dosio, F.2    Cattel, L.3
  • 5
    • 0031729149 scopus 로고    scopus 로고
    • Liposomal Drug Formulations -Rationale for Development and What We Can Expect for the Future
    • Allen, T. Liposomal Drug Formulations-Rationale for Development and What We Can Expect for the Future Drugs 1998, 56, 747-756
    • (1998) Drugs , vol.56 , pp. 747-756
    • Allen, T.1
  • 6
    • 77953412389 scopus 로고    scopus 로고
    • Understanding and Overcoming Major Barriers in Cancer Nanomedicine
    • Nie, S. Understanding and Overcoming Major Barriers in Cancer Nanomedicine Nanomedicine 2010, 5, 523-528
    • (2010) Nanomedicine , vol.5 , pp. 523-528
    • Nie, S.1
  • 7
    • 0037407394 scopus 로고    scopus 로고
    • Targeting Doxorubicin to Epidermal Growth Factor Receptors by Site-Specific Conjugation of C225 to Poly(l -glutamic acid) through a Polyethylene Glycol Spacer
    • Vega, J.; Ke, S.; Fan, Z.; Wallace, S.; Charsangavej, C.; Li, C. Targeting Doxorubicin to Epidermal Growth Factor Receptors by Site-Specific Conjugation of C225 to Poly(l -glutamic acid) through a Polyethylene Glycol Spacer Pharm. Res. 2003, 20, 826-832
    • (2003) Pharm. Res. , vol.20 , pp. 826-832
    • Vega, J.1    Ke, S.2    Fan, Z.3    Wallace, S.4    Charsangavej, C.5    Li, C.6
  • 8
    • 39749160560 scopus 로고    scopus 로고
    • Antibody-Targeted Liposomes in Cancer Therapy and Imaging
    • Sofou, S.; Sgouros, G. Antibody-Targeted Liposomes in Cancer Therapy and Imaging Expert Opin. Drug Delivery 2008, 5, 189-204
    • (2008) Expert Opin. Drug Delivery , vol.5 , pp. 189-204
    • Sofou, S.1    Sgouros, G.2
  • 9
    • 4644349816 scopus 로고    scopus 로고
    • Liposomes Modified with Cyclic RGD Peptide for Tumor Targeting
    • Dubey, P.; Mishra, V.; Jain, S.; Mahor, S.; Vyas, S. Liposomes Modified with Cyclic RGD Peptide for Tumor Targeting J. Drug Target. 2004, 12, 257-264
    • (2004) J. Drug Target. , vol.12 , pp. 257-264
    • Dubey, P.1    Mishra, V.2    Jain, S.3    Mahor, S.4    Vyas, S.5
  • 10
    • 14144250911 scopus 로고    scopus 로고
    • Recent Advances with Liposomes as Pharmaceutical Carriers
    • Torchilin, V. Recent Advances with Liposomes as Pharmaceutical Carriers Nat. Rev. Drug Discovery 2005, 4, 145-160
    • (2005) Nat. Rev. Drug Discovery , vol.4 , pp. 145-160
    • Torchilin, V.1
  • 11
    • 45549089546 scopus 로고    scopus 로고
    • New Approaches to the Therapy of Various Tumors Based on Peptide Analogues
    • Schally, A. V. New Approaches to the Therapy of Various Tumors Based on Peptide Analogues. Horm. Metab. Res. 2008, 40.
    • (2008) Horm. Metab. Res. , vol.40
    • Schally, A.V.1
  • 13
    • 0036781811 scopus 로고    scopus 로고
    • Ligand-Targeted Therapeutics in Anticancer Therapy
    • Allen, T. Ligand-Targeted Therapeutics in Anticancer Therapy Nat. Rev. Cancer 2002, 2, 750-763
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 750-763
    • Allen, T.1
  • 14
    • 33746648133 scopus 로고    scopus 로고
    • Emerging Use of Nanoparticles in Diagnosis and Treatment of Breast Cancer
    • Yezhelyev, M. V.; Gao, X.; Xing, Y.; Al-Hajj, A.; Nie, S.; O'Regan, R. M. Emerging Use of Nanoparticles in Diagnosis and Treatment of Breast Cancer Lancet Oncol. 2006, 7, 657-667
    • (2006) Lancet Oncol. , vol.7 , pp. 657-667
    • Yezhelyev, M.V.1    Gao, X.2    Xing, Y.3    Al-Hajj, A.4    Nie, S.5    O'Regan, R.M.6
  • 15
    • 33748344520 scopus 로고    scopus 로고
    • Nanotechnology in Cancer Therapeutics: Bioconjugated Nanoparticles for Drug Delivery
    • Sinha, R.; Kim, G. J.; Nie, S.; Shin, D. M. Nanotechnology in Cancer Therapeutics: Bioconjugated Nanoparticles for Drug Delivery Mol. Cancer Ther. 2006, 5, 1909-1917
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 1909-1917
    • Sinha, R.1    Kim, G.J.2    Nie, S.3    Shin, D.M.4
  • 16
    • 14644439267 scopus 로고    scopus 로고
    • Cancer Nanotechnology: Opportunities and Challenges
    • Ferrari, M. Cancer Nanotechnology: Opportunities and Challenges Nat. Rev. Cancer 2005, 5, 161-171
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 161-171
    • Ferrari, M.1
  • 17
    • 61849153021 scopus 로고    scopus 로고
    • Impact of Nanotechnology on Drug Delivery
    • Farokhzad, O. C.; Langer, R. Impact of Nanotechnology on Drug Delivery ACS Nano 2009, 3, 16-20
    • (2009) ACS Nano , vol.3 , pp. 16-20
    • Farokhzad, O.C.1    Langer, R.2
  • 18
    • 51249122212 scopus 로고    scopus 로고
    • Does a Targeting Ligand Influence Nanoparticle Tumor Localization or Uptake?
    • Pirollo, K. F.; Chang, E. H. Does a Targeting Ligand Influence Nanoparticle Tumor Localization or Uptake? Curr. Trends Biotechnol. 2008, 26, 552-558
    • (2008) Curr. Trends Biotechnol. , vol.26 , pp. 552-558
    • Pirollo, K.F.1    Chang, E.H.2
  • 19
    • 34848918210 scopus 로고    scopus 로고
    • Impact of Tumor-Specific Targeting on the Biodistribution and Efficacy of siRNA Nanoparticles Measured by Multimodality in Vivo Imaging
    • Bartlett, D. W.; Su, H.; Hildebrandt, I. J.; Weber, W. A.; Davis, M. E. Impact of Tumor-Specific Targeting on the Biodistribution and Efficacy of siRNA Nanoparticles Measured by Multimodality in Vivo Imaging Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 15549-15554
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 15549-15554
    • Bartlett, D.W.1    Su, H.2    Hildebrandt, I.J.3    Weber, W.A.4    Davis, M.E.5
  • 20
    • 33746172167 scopus 로고    scopus 로고
    • Antibody Targeting of Long-Circulating Lipidic Nanoparticles Does Not Increase Tumor Localization but Does Increase Internalization in Animal Models
    • Kirpotin, D. B.; Drummond, D. C.; Shao, Y.; Shalaby, M. R.; Hong, K.; Nielsen, U. B.; Marks, J. D.; Benz, C. C.; Park, J. W. Antibody Targeting of Long-Circulating Lipidic Nanoparticles Does Not Increase Tumor Localization but Does Increase Internalization in Animal Models Cancer Res. 2006, 66, 6732-6740
    • (2006) Cancer Res. , vol.66 , pp. 6732-6740
    • Kirpotin, D.B.1    Drummond, D.C.2    Shao, Y.3    Shalaby, M.R.4    Hong, K.5    Nielsen, U.B.6    Marks, J.D.7    Benz, C.C.8    Park, J.W.9
  • 21
    • 35748963560 scopus 로고    scopus 로고
    • Tumor Targeting with RGD Peptide Ligands-Design of New Molecular Conjugates for Imaging and Therapy of Cancers
    • Garanger, E.; Boturyn, D.; Dumy, P. Tumor Targeting with RGD Peptide Ligands-Design of New Molecular Conjugates for Imaging and Therapy of Cancers Anti-Cancer Agents Med. Chem. 2007, 7, 552-558
    • (2007) Anti-Cancer Agents Med. Chem. , vol.7 , pp. 552-558
    • Garanger, E.1    Boturyn, D.2    Dumy, P.3
  • 22
    • 27944455140 scopus 로고    scopus 로고
    • Folate Receptor-Mediated Drug Targeting: From Therapeutics to Diagnostics
    • Hilgenbrink, A.; Low, P. Folate Receptor-Mediated Drug Targeting: From Therapeutics to Diagnostics J. Pharm. Sci. 2005, 94, 2135-2146
    • (2005) J. Pharm. Sci. , vol.94 , pp. 2135-2146
    • Hilgenbrink, A.1    Low, P.2
  • 23
    • 0033544904 scopus 로고    scopus 로고
    • Transferrin-Liposome-Mediated Systemic p53 Gene Therapy in Combination with Radiation Results in Regression of Human Head and Neck Cancer Xenografts
    • Xu, L.; Pirollo, K.; Tang, W.; Rait, A.; Chang, E. Transferrin-Liposome- Mediated Systemic p53 Gene Therapy in Combination with Radiation Results in Regression of Human Head and Neck Cancer Xenografts Hum. Gene Ther. 1999, 10, 2941-2952
    • (1999) Hum. Gene Ther. , vol.10 , pp. 2941-2952
    • Xu, L.1    Pirollo, K.2    Tang, W.3    Rait, A.4    Chang, E.5
  • 24
    • 33750008791 scopus 로고    scopus 로고
    • The Transferrin Receptor Part I: Biology and Targeting with Cytotoxic Antibodies for the Treatment of Cancer
    • Daniels, T. R.; Delgado, T.; Rodriguez, J. A.; Helguera, G.; Penichet, M. L. The Transferrin Receptor Part I: Biology and Targeting with Cytotoxic Antibodies for the Treatment of Cancer Clin. Immunol. 2006, 121, 144-158
    • (2006) Clin. Immunol. , vol.121 , pp. 144-158
    • Daniels, T.R.1    Delgado, T.2    Rodriguez, J.A.3    Helguera, G.4    Penichet, M.L.5
  • 25
    • 0025731906 scopus 로고
    • Liposomes Containing Synthetic Lipid Derivatives of Poly(ethylene glycol) Show Prolonged Circulation Half-Lives in Vivo
    • Allen, T. M.; Hansen, C.; Martin, F.; Redemann, C.; Yauyoung, A. Liposomes Containing Synthetic Lipid Derivatives of Poly(ethylene glycol) Show Prolonged Circulation Half-Lives in Vivo. Biochim. Biophys. Acta 1991, 1066.
    • (1991) Biochim. Biophys. Acta , vol.1066
    • Allen, T.M.1    Hansen, C.2    Martin, F.3    Redemann, C.4    Yauyoung, A.5
  • 26
    • 0031021149 scopus 로고    scopus 로고
    • Sterically Stabilized Anti-HER2 Immunoliposomes: Design and Targeting to Human Breast Cancer Cells in Vitro
    • Kirpotin, D.; Park, J.; Hong, K.; Zalipsky, S.; Li, W.; Carter, P.; Benz, C.; Papahadjopoulos, D. Sterically Stabilized Anti-HER2 Immunoliposomes: Design and Targeting to Human Breast Cancer Cells in Vitro Biochemistry 1997, 36, 66-75
    • (1997) Biochemistry , vol.36 , pp. 66-75
    • Kirpotin, D.1    Park, J.2    Hong, K.3    Zalipsky, S.4    Li, W.5    Carter, P.6    Benz, C.7    Papahadjopoulos, D.8
  • 27
    • 0038797831 scopus 로고    scopus 로고
    • Ligand-Targeted Liposomal Anticancer Drugs
    • Sapra, P.; Allen, T. Ligand-Targeted Liposomal Anticancer Drugs Prog. Lipid Res. 2003, 42, 439-462
    • (2003) Prog. Lipid Res. , vol.42 , pp. 439-462
    • Sapra, P.1    Allen, T.2
  • 30
    • 6444244496 scopus 로고    scopus 로고
    • Controlling the Physical Behavior and Biological Performance of Liposome Formulations through Use of Surface Grafted Poly(ethylene glycol)
    • Allen, C.; Dos Santos, N.; Gallagher, R.; Chiu, G.; Shu, Y.; Li, W.; Johnstone, S.; Janoff, A.; Mayer, L.; Webb, M. et al. Controlling the Physical Behavior and Biological Performance of Liposome Formulations through Use of Surface Grafted Poly(ethylene glycol) Biosci. Rep. 2002, 22, 225-250
    • (2002) Biosci. Rep. , vol.22 , pp. 225-250
    • Allen, C.1    Dos Santos, N.2    Gallagher, R.3    Chiu, G.4    Shu, Y.5    Li, W.6    Johnstone, S.7    Janoff, A.8    Mayer, L.9    Webb, M.10
  • 32
    • 0031911294 scopus 로고    scopus 로고
    • Hydration of Polyethylene Glycol-Grafted Liposomes
    • Tirosh, O.; Barenholz, Y.; Katzhendler, J.; Priev, A. Hydration of Polyethylene Glycol-Grafted Liposomes Biophys. J. 1998, 74, 1371-1379
    • (1998) Biophys. J. , vol.74 , pp. 1371-1379
    • Tirosh, O.1    Barenholz, Y.2    Katzhendler, J.3    Priev, A.4
  • 33
  • 35
    • 36348935200 scopus 로고    scopus 로고
    • Peptide-Mediated Targeting to Tumor Blood Vessels of Lung Cancer for Drug Delivery
    • Lee, T.; Lin, C.; Kuo, S.; Chang, D.; Wu, H. Peptide-Mediated Targeting to Tumor Blood Vessels of Lung Cancer for Drug Delivery Cancer Res. 2007, 67, 10958-10965
    • (2007) Cancer Res. , vol.67 , pp. 10958-10965
    • Lee, T.1    Lin, C.2    Kuo, S.3    Chang, D.4    Wu, H.5
  • 36
    • 3843050301 scopus 로고    scopus 로고
    • Enhanced Heparan Sulfate Proteoglycan-Mediated Uptake of Cell-Penetrating Peptide-Modified Liposomes
    • Marty, C.; Meylan, C.; Schott, H.; Ballmer-Hofer, K.; Schwendener, R. A. Enhanced Heparan Sulfate Proteoglycan-Mediated Uptake of Cell-Penetrating Peptide-Modified Liposomes. Cell. Mol. Life Sci. 2004, 61.
    • (2004) Cell. Mol. Life Sci. , vol.61
    • Marty, C.1    Meylan, C.2    Schott, H.3    Ballmer-Hofer, K.4    Schwendener, R.A.5
  • 37
    • 0035902477 scopus 로고    scopus 로고
    • TAT Peptide on the Surface of Liposomes Affords Their Efficient Intracellular Delivery even at Low Temperature and in the Presence of Metabolic Inhibitors
    • Torchilin, V. P.; Rammohan, R.; Weissig, V.; Levchenko, T. S. TAT Peptide on the Surface of Liposomes Affords Their Efficient Intracellular Delivery Even at Low Temperature and in the Presence of Metabolic Inhibitors Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 8786-8791
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 8786-8791
    • Torchilin, V.P.1    Rammohan, R.2    Weissig, V.3    Levchenko, T.S.4
  • 38
    • 0028884966 scopus 로고
    • Attachment of Antibodies to Sterically Stabilized Liposomes -Evaluation, Comparison and Optimization of Coupling Procedures
    • Hansen, C.; Kao, G.; Moase, E.; Zalipsky, S.; Allen, T. Attachment of Antibodies to Sterically Stabilized Liposomes-Evaluation, Comparison and Optimization of Coupling Procedures Biochim. Biophys. Acta, Biomembr. 1995, 1239, 133-144
    • (1995) Biochim. Biophys. Acta, Biomembr. , vol.1239 , pp. 133-144
    • Hansen, C.1    Kao, G.2    Moase, E.3    Zalipsky, S.4    Allen, T.5
  • 39
    • 0035284411 scopus 로고    scopus 로고
    • Peptide and Protein PEGylation: A Review of Problems and Solutions
    • Veronese, F. Peptide and Protein PEGylation: A Review of Problems and Solutions Biomaterials 2001, 22, 405-417
    • (2001) Biomaterials , vol.22 , pp. 405-417
    • Veronese, F.1
  • 40
    • 3042722268 scopus 로고    scopus 로고
    • Protein, Peptide and Nonpeptide Drug PEGylation for Therapeutic Application
    • Pasut, G.; Guiotto, A.; Veronese, F. Protein, Peptide and Nonpeptide Drug PEGylation for Therapeutic Application Expert Opin. Ther. Pat. 2004, 14, 859-894
    • (2004) Expert Opin. Ther. Pat. , vol.14 , pp. 859-894
    • Pasut, G.1    Guiotto, A.2    Veronese, F.3
  • 41
    • 3843112386 scopus 로고    scopus 로고
    • Current Methods for Attaching Targeting Ligands to Liposomes and Nanoparticles
    • Nobs, L.; Buchegger, F.; Gurny, R.; Allemann, E. Current Methods for Attaching Targeting Ligands to Liposomes and Nanoparticles J. Pharm. Sci. 2004, 93, 1980-1992
    • (2004) J. Pharm. Sci. , vol.93 , pp. 1980-1992
    • Nobs, L.1    Buchegger, F.2    Gurny, R.3    Allemann, E.4
  • 43
    • 37049183697 scopus 로고
    • Human-Breast Cancer -Correlation of Relapse and Survival with Amplification of the Her-2 Neu Oncogene
    • Slamon, D. J.; Clark, G. M.; Wong, S. G.; Levin, W. J.; Ullrich, A.; Mcguire, W. L. Human-Breast Cancer-Correlation of Relapse and Survival with Amplification of the Her-2 Neu Oncogene. Science 1987, 235.
    • (1987) Science , vol.235
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 45
    • 0032535999 scopus 로고    scopus 로고
    • Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model
    • Arap, W.; Pasqualini, R.; Ruoslahti, E. Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model Science 1998, 279, 377-380
    • (1998) Science , vol.279 , pp. 377-380
    • Arap, W.1    Pasqualini, R.2    Ruoslahti, E.3
  • 49
    • 0042854927 scopus 로고    scopus 로고
    • Peptide Receptors as Molecular Targets for Cancer Diagnosis and Therapy
    • Reubi, J. Peptide Receptors as Molecular Targets for Cancer Diagnosis and Therapy Endocr. Rev. 2003, 24, 389-427
    • (2003) Endocr. Rev. , vol.24 , pp. 389-427
    • Reubi, J.1
  • 50
  • 51
    • 0032476812 scopus 로고    scopus 로고
    • Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors
    • Mammen, M.; Choi, S. K.; Whitesides, G. M. Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors Angew. Chem., Int. Ed. 1998, 37, 2755-2794
    • (1998) Angew. Chem., Int. Ed. , vol.37 , pp. 2755-2794
    • Mammen, M.1    Choi, S.K.2    Whitesides, G.M.3
  • 52
    • 0035797362 scopus 로고    scopus 로고
    • Disabling ErbB Receptors with Rationally Designed Exocyclic Mimetics of Antibodies: Structure-Function Analysis
    • Berezov, A.; Zhang, H. T.; Greene, M. I.; Murali, R. Disabling ErbB Receptors with Rationally Designed Exocyclic Mimetics of Antibodies: Structure-Function Analysis J. Med. Chem. 2001, 44, 2565-2574
    • (2001) J. Med. Chem. , vol.44 , pp. 2565-2574
    • Berezov, A.1    Zhang, H.T.2    Greene, M.I.3    Murali, R.4
  • 53
    • 0033106119 scopus 로고    scopus 로고
    • Targeting Folate Receptor with Folate Linked to Extremities of Poly(ethylene glycol)-Grafted Liposomes: In Vitro Studies
    • Gabizon, A.; Horowitz, A.; Goren, D.; Tzemach, D.; Mandelbaum-Shavit, F.; Qazen, M.; Zalipsky, S. Targeting Folate Receptor with Folate Linked to Extremities of Poly(ethylene glycol)-Grafted Liposomes: in Vitro Studies Bioconjugate Chem. 1999, 10, 289-298
    • (1999) Bioconjugate Chem. , vol.10 , pp. 289-298
    • Gabizon, A.1    Horowitz, A.2    Goren, D.3    Tzemach, D.4    Mandelbaum-Shavit, F.5    Qazen, M.6    Zalipsky, S.7
  • 54
    • 77957921048 scopus 로고    scopus 로고
    • Folate-Targeted Therapies for Cancer
    • Xia, W.; Low, P. S. Folate-Targeted Therapies for Cancer J. Med. Chem. 2010, 53, 6811-6824
    • (2010) J. Med. Chem. , vol.53 , pp. 6811-6824
    • Xia, W.1    Low, P.S.2
  • 55
    • 0032135083 scopus 로고    scopus 로고
    • Very Late Antigen 4 (VLA4) Antagonists as Anti-inflammatory Agents
    • Lin, K.; Castro, A. Very Late Antigen 4 (VLA4) Antagonists as Anti-inflammatory Agents Curr. Opin. Chem. Biol. 1998, 2, 453-457
    • (1998) Curr. Opin. Chem. Biol. , vol.2 , pp. 453-457
    • Lin, K.1    Castro, A.2
  • 58
    • 84864046050 scopus 로고    scopus 로고
    • Rationally Engineered Nanoparticles Target Multiple Myeloma Cells, Overcome Cell-Adhesion-Mediated Drug Resistance, and Show Enhanced Efficacy in Vivo
    • Kiziltepe, T.; Ashley, J. D.; Stefanick, J. F.; Qi, Y. M.; Alves, N. J.; Handlogten, M. W.; Suckow, M. A.; Navari, R. M.; Bilgicer, B. Rationally Engineered Nanoparticles Target Multiple Myeloma Cells, Overcome Cell-Adhesion-Mediated Drug Resistance, and Show Enhanced Efficacy in Vivo Blood Cancer J. 2012, 2, e64
    • (2012) Blood Cancer J. , vol.2 , pp. 64
    • Kiziltepe, T.1    Ashley, J.D.2    Stefanick, J.F.3    Qi, Y.M.4    Alves, N.J.5    Handlogten, M.W.6    Suckow, M.A.7    Navari, R.M.8    Bilgicer, B.9
  • 59
    • 79956112931 scopus 로고    scopus 로고
    • The Long View of Nanotechnology Development: The National Nanotechnology Initiative at 10 Years
    • Roco, M. C. The Long View of Nanotechnology Development: The National Nanotechnology Initiative at 10 Years J. Nanopart. Res. 2011, 13, 427-445
    • (2011) J. Nanopart. Res. , vol.13 , pp. 427-445
    • Roco, M.C.1
  • 60
    • 0018719041 scopus 로고
    • Preparation of Liposomes of Defined Size Distribution by Extrusion through Polycarbonate Membranes
    • Olson, F.; Hunt, C. A.; Szoka, F. C.; Vail, W. J.; Papahadjopoulos, D. Preparation of Liposomes of Defined Size Distribution by Extrusion through Polycarbonate Membranes Biochim. Biophys. Acta 1979, 557
    • (1979) Biochim. Biophys. Acta , pp. 557
    • Olson, F.1    Hunt, C.A.2    Szoka, F.C.3    Vail, W.J.4    Papahadjopoulos, D.5


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