Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery

Journal of Controlled Release

Volumn 142, Issue 3, 2010, Pages 416-421

  Li, Jun ^a   Chen, Yun Ching ^a   Tseng, Yu Cheng ^a   Mozumdar, Subho ^b   Huang, Leaf ^a  

^a University of North Carolina   (United States)

^b UNIVERSITY OF DELHI   (India)

Author keywords

Calcium phosphate; Cancer; Nanoparticle; PEGylation; siRNA

Indexed keywords

CALCIUM PHOSPHATE NANOPARTICLES; CATIONIC LIPOSOMES; ENDOSOMES; GENE SILENCING; IMMUNOTOXICITY; IN-VITRO; INTRACELLULAR CA; INTRAVENOUS ADMINISTRATION; LIPID COATING; LUCIFERASE ACTIVITIES; LUCIFERASE GENES; NANO-SIZED; PEGYLATION; POLYCATIONS; RECEPTOR LIGANDS; SIRNA DELIVERY; SMALL INTERFERING RNA (SIRNA); SYSTEMIC ADMINISTRATION; TUMOR CELLS; TUMOR MODELS; WATER-IN-OIL;

AUTOMOBILE SEATS; BIOLOGICAL MATERIALS; CALCIUM; CALCIUM ALLOYS; CELL CULTURE; DNA; ENZYME ACTIVITY; GENES; GENETIC ENGINEERING; NANOPARTICLES; OPTICAL PROJECTORS; PHOSPHATES; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; RNA; TUMORS;

CALCIUM PHOSPHATE;

CALCIUM; CALCIUM PHOSPHATE; FURA 2; LIPID; LUCIFERASE; MACROGOL; NANOPARTICLE; OIL; SMALL INTERFERING RNA; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIODEGRADABILITY; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG COATING; DRUG FORMULATION; ENDOSOME; ENZYME ACTIVITY; FEMALE; GENE SILENCING; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IMMUNOTOXICITY; IN VITRO STUDY; IN VIVO STUDY; MALIGNANT NEOPLASTIC DISEASE; MICROEMULSION; MOUSE; NANOENCAPSULATION; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PH; PRIORITY JOURNAL; RNA INTERFERENCE; TUMOR XENOGRAFT;

ANIMALS; CALCIUM; CALCIUM PHOSPHATES; CELL LINE, TUMOR; COATED MATERIALS, BIOCOMPATIBLE; CYTOKINES; DRUG CARRIERS; DRUG COMPOUNDING; FEMALE; GENE SILENCING; INJECTIONS, INTRAVENOUS; LIPIDS; LUCIFERASES; MICE; MICE, NUDE; NANOPARTICLES; NEOPLASMS, EXPERIMENTAL; POLYETHYLENE GLYCOLS; RNA, SMALL INTERFERING; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77349109732     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.11.008     Document Type: Article

References (28)

1. Chen Y., Sen J., Bathula S.R., Yang Q., Fittipaldi R., and Huang L. Novel cationic lipid that delivers siRNA and enhances therapeutic effect in lung cancer cells. Mol Pharm 6 3 (2009) 696-705
2. Li S.D., Chen Y.C., Hackett M.J., and Huang L. Tumor-targeted delivery of siRNA by self-assembled nanoparticles. Mol Ther 16 1 (2008) 163-169
3. Li S.D., and Huang L. Targeted delivery of antisense oligodeoxynucleotide and small interference RNA into lung cancer cells. Mol Pharm 3 5 (2006) 579-588
4. Li S., and Huang L. In vivo gene transfer via intravenous administration of cationic lipid-protamine-DNA (LPD) complexes. Gene Ther 4 9 (1997) 891-900
5. Mukherjee A., Prasad T.K., Rao N.M., and Banerjee R. Haloperidol-associated stealth liposomes: a potent carrier for delivering genes to human breast cancer cells. J Biol Chem 280 16 (2005) 15619-15627
6. Chono S., Li S.D., Conwell C.C., and Huang L. An efficient and low immunostimulatory nanoparticle formulation for systemic siRNA delivery to the tumor. J Control Release 131 1 (2008) 64-69
7. Sokolova V., and Epple M. Inorganic nanoparticles as carriers of nucleic acids into cells. Angew Chem Int Ed Engl 47 8 (2008) 1382-1395
8. Bisht S., Bhakta G., Mitra S., and Maitra A. pDNA loaded calcium phosphate nanoparticles: highly efficient non-viral vector for gene delivery. Int J Pharm 288 1 (2005) 157-168
9. Olton D., Li J., Wilson M.E., Rogers T., Close J., Huang L., Kumta P.N., and Sfeir C. Nanostructured calcium phosphates (NanoCaPs) for non-viral gene delivery: influence of the synthesis parameters on transfection efficiency. Biomaterials 28 6 (2007) 1267-1279
10. Maitra A. Calcium phosphate nanoparticles: second-generation nonviral vectors in gene therapy. Expert Rev Mol Diagn 5 6 (2005) 893-905
11. Roy I., Mitra S., Maitra A., and Mozumdar S. Calcium phosphate nanoparticles as novel non-viral vectors for targeted gene delivery. Int J Pharm 250 1 (2003) 25-33
12. Eufinger H., Rasche C., Lehmbrock J., Wehmoller M., Weihe S., Schmitz I., Schiller C., and Epple M. Performance of functionally graded implants of polylactides and calcium phosphate/calcium carbonate in an ovine model for computer assisted craniectomy and cranioplasty. Biomaterials 28 3 (2007) 475-485
13. Sokolova V.V., Radtke I., Heumann R., and Epple M. Effective transfection of cells with multi-shell calcium phosphate-DNA nanoparticles. Biomaterials 27 16 (2006) 3147-3153
14. Welzel T., Meyer-Zaika W., and Epple M. Continuous preparation of functionalised calcium phosphate nanoparticles with adjustable crystallinity. Chem Commun (Camb) 10 (2004) 1204-1205
15. Liu T., Tang A., Zhang G., Chen Y., Zhang J., Peng S., and Cai Z. Calcium phosphate nanoparticles as a novel nonviral vector for efficient transfection of DNA in cancer gene therapy. Cancer Biother Radiopharm 20 2 (2005) 141-149
16. Banerjee R., Tyagi P., Li S., and Huang L. Anisamide-targeted stealth liposomes: a potent carrier for targeting doxorubicin to human prostate cancer cells. Int J Cancer 112 4 (2004) 693-700
17. Li S.D., Chono S., and Huang L. Efficient gene silencing in metastatic tumor by siRNA formulated in surface-modified nanoparticles. J Control Release 126 1 (2008) 77-84
18. Hirst R.A., Harrison C., Hirota K., and Lambert D.G. Measurement of [Ca2+]i in whole cell suspensions using fura-2. Methods Mol Biol 114 (1999) 31-39
19. Tseng Y.C., Mozumdar S., and Huang L. Lipid-based systemic delivery of siRNA. Adv Drug Deliv Rev 61 9 (2009) 721-731
20. Thomas M., and Klibanov A.M. Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells. Proc Natl Acad Sci U S A 99 23 (2002) 14640-14645
21. Yang S., and May S. Release of cationic polymer-DNA complexes from the endosome: a theoretical investigation of the proton sponge hypothesis. J Chem Phys 129 18 (2008) 185105
22. Hafez I.M., Maurer N., and Cullis P.R. On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids. Gene Ther 8 15 (2001) 1188-1196
23. Torchilin V.P. Recent advances with liposomes as pharmaceutical carriers. Nat Rev Drug Discov 4 2 (2005) 145-160
24. V. Sokolova, M. Epple, Inorganic Nanoparticles as Carriers of Nucleic Acids into Cells. Angew Chem Int Ed Engl 47 (8) (2008) 1382-1395.
25. Graham F.L., and van der Eb A.J. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52 2 (1973) 456-467
26. Li S.D., and Huang L. Nanoparticles evading the reticuloendothelial system: role of the supported bilayer. Biochim Biophys Acta 1788 10 (2009) 2259-2266
27. Morgan T.T., Muddana H.S., Altinoglu E.I., Rouse S.M., Tabakovic A., Tabouillot T., Russin T.J., Shanmugavelandy S.S., Butler P.J., Eklund P.C., Yun J.K., Kester M., and Adair J.H. Encapsulation of organic molecules in calcium phosphate nanocomposite particles for intracellular imaging and drug delivery. Nano Lett 8 12 (2008) 4108-4115
28. Wier W.G., Beuckelmann D.J., and Barcenas-Ruiz L. [Ca2+]i in single isolated cardiac cells: a review of recent results obtained with digital imaging microscopy and fura-2. Can J Physiol Pharmacol 66 9 (1988) 1224-1231