PH-sensitive siRNA nanovector for targeted gene silencing and cytotoxic effect in cancer cells

Molecular Pharmaceutics

Volumn 7, Issue 6, 2010, Pages 1930-1939

  Mok, Hyejung ^a   Veiseh, Omid ^a   Fang, Chen ^a   Kievit, Forrest M ^a   Wang, Freddy Y ^a   Park, James O ^b   Zhang, Miqin ^a,b  

^a University of Washington   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROTOXIN; CITRACONIC ANHYDRIDE; DISULFIDE; IRON OXIDE; MACROGOL; MAGNETIC NANOPARTICLE; POLYETHYLENEIMINE; SMALL INTERFERING RNA; TOXIN; UNCLASSIFIED DRUG;

ACIDITY; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; CANCER CELL; CELL VIABILITY; CONJUGATION; CONTROLLED STUDY; COVALENT BOND; CYTOTOXICITY; GENE SILENCING; GENE TARGETING; GENE VECTOR; GLIOMA CELL; HYDROPHILICITY; INTERNALIZATION; MAGNETISM; MOLECULAR IMAGING; MOLECULAR SIZE; NANOTECHNOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PH; PRIORITY JOURNAL; RNA VECTOR; TUMOR MICROENVIRONMENT;

ANIMALS; CELL LINE, TUMOR; CELL SURVIVAL; CONTRAST MEDIA; FERRIC COMPOUNDS; GENE SILENCING; GLIOMA; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE IMAGING; MAGNETICS; MOLECULAR STRUCTURE; NANOPARTICLES; PARTICLE SIZE; POLYETHYLENEIMINE; RNA, SMALL INTERFERING; SCORPION VENOMS;

EID: 78649962007     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp100221h     Document Type: Article

References (43)

1. Mok, H.; Lee, S. H.; Park, J. W.; Park, T. G. Multimeric small interfering ribonucleic acid for highly efficient sequence-specific gene silencing Nat. Mater. 2010, 9 (3) 272-8
2. Extance, A. Targeting RNA: an emerging hope for treating muscular dystrophy Nat. Rev. Drug Discovery 2009, 8 (12) 917-8
3. Derfus, A. M.; Chen, A. A.; Min, D. H.; Ruoslahti, E.; Bhatia, S. N. Targeted quantum dot conjugates for siRNA delivery Bioconjugate Chem. 2007, 18 (5) 1391-6
4. Lee, J. H.; Lee, K.; Moon, S. H.; Lee, Y.; Park, T. G.; Cheon, J. All-in-one target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery Angew. Chem., Int. Ed. 2009, 48 (23) 4174-9
5. Ghosh, P. S.; Kim, C. K.; Han, G.; Forbes, N. S.; Rotello, V. M. Efficient gene delivery vectors by tuning the surface charge density of amino acid-functionalized gold nanoparticles ACS Nano 2008, 2 (11) 2213-8
6. Lee, J. S.; Green, J. J.; Love, K. T.; Sunshine, J.; Langer, R.; Anderson, D. G. Gold, poly(beta-amino ester) nanoparticles for small interfering RNA delivery Nano Lett. 2009, 9 (6) 2402-6
7. Shubayev, V. I.; Pisanic, T. R., 2nd; Jin, S. Magnetic nanoparticles for theragnostics Adv. Drug Delivery Rev. 2009, 61 (6) 467-77
8. Kievit, F. M.; Veiseh, O.; Bhattarai, N.; Fang, C.; Gunn, J. W.; Lee, D.; Ellenbogen, R. G.; Olson, J. M.; Zhang, M. PEI-PEG-Chitosan Copolymer Coated Iron Oxide Nanoparticles for Safe Gene Delivery: synthesis, complexation, and transfection Adv. Funct. Mater. 2009, 19 (14) 2244-2251
9. Hussain, S. M.; Hess, K. L.; Gearhart, J. M.; Geiss, K. T.; Schlager, J. J. In vitro toxicity of nanoparticles in BRL 3A rat liver cells Toxicol. in Vitro 2005, 19 (7) 975-83
10. Fang, C.; Bhattarai, N.; Sun, C.; Zhang, M. Functionalized nanoparticles with long-term stability in biological media Small 2009, 5 (14) 1637-41
11. Mok, H.; Park, J. W.; Park, T. G. Enhanced intracellular delivery of quantum dot and adenovirus nanoparticles triggered by acidic pH via surface charge reversal Bioconjugate Chem. 2008, 19 (4) 797-801
12. Xiang, J. J.; Tang, J. Q.; Zhu, S. G.; Nie, X. M.; Lu, H. B.; Shen, S. R.; Li, X. L.; Tang, K.; Zhou, M.; Li, G. Y. IONP-PLL: a novel non-viral vector for efficient gene delivery J. Gene Med. 2003, 5 (9) 803-17
13. Thomas, M.; Klibanov, A. M. Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells Proc. Natl. Acad. Sci. U.S.A. 2002, 99 (23) 14640-5
14. Park, T. G.; Jeong, J. H.; Kim, S. W. Current status of polymeric gene delivery systems Adv. Drug Delivery Rev. 2006, 58 (4) 467-86
15. Song, W. J.; Du, J. Z.; Sun, T. M.; Zhang, P. Z.; Wang, J. Gold nanoparticles capped with polyethyleneimine for enhanced siRNA delivery Small 2010, 6 (2) 239-46
16. Hunter, A. C. Molecular hurdles in polyfectin design and mechanistic background to polycation induced cytotoxicity Adv. Drug Delivery Rev. 2006, 58 (14) 1523-31
17. Fischer, D.; Li, Y.; Ahlemeyer, B.; Krieglstein, J.; Kissel, T. In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis Biomaterials 2003, 24 (7) 1121-31
18. Hoon Jeong, J.; Christensen, L. V.; Yockman, J. W.; Zhong, Z.; Engbersen, J. F.; Jong Kim, W.; Feijen, J.; Wan Kim, S. Reducible poly(amido ethylenimine) directed to enhance RNA interference Biomaterials 2007, 28 (10) 1912-7
19. Veiseh, O.; Kievit, F. M.; Gunn, J. W.; Ratner, B. D.; Zhang, M. A ligand-mediated nanovector for targeted gene delivery and transfection in cancer cells Biomaterials 2009, 30 (4) 649-57
20. Aravindan, L.; Bicknell, K. A.; Brooks, G.; Khutoryanskiy, V. V.; Williams, A. C. Effect of acyl chain length on transfection efficiency and toxicity of polyethylenimine Int. J. Pharm. 2009, 378 (1-2) 201-10
21. Gabrielson, N. P.; Pack, D. W. Acetylation of polyethylenimine enhances gene delivery via weakened polymer/DNA interactions Biomacromolecules 2006, 7 (8) 2427-35
22. Lee, Y.; Fukushima, S.; Bae, Y.; Hiki, S.; Ishii, T.; Kataoka, K. A protein nanocarrier from charge-conversion polymer in response to endosomal pH J. Am. Chem. Soc. 2007, 129 (17) 5362-3
23. Vaupel, P. W.; Frinak, S.; Bicher, H. I. Heterogeneous oxygen partial pressure and pH distribution in C3H mouse mammary adenocarcinoma Cancer Res. 1981, 41 (5) 2008-13
24. Mashima, T.; Sato, S.; Sugimoto, Y.; Tsuruo, T.; Seimiya, H. Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions Oncogene 2009, 28 (1) 9-19
25. Swietach, P.; Vaughan-Jones, R. D.; Harris, A. L. Regulation of tumor pH and the ro le of carbonic anhydrase 9 Cancer Metastasis Rev. 2007, 26 (2) 299-310
26. Min, K. H.; Kim, J. H.; Bae, S. M.; Shin, H.; Kim, M. S.; Park, S.; Lee, H.; Park, R. W.; Kim, I. S.; Kim, K.; Kwon, I. C.; Jeong, S. Y.; Lee, D. S. Tumoral acidic pH-responsive MPEG-poly(beta-amino ester) polymeric micelles for cancer targeting therapy J. Controlled Release 2010, 144 (2) 259-66
27. Sethuraman, V. A.; Na, K.; Bae, Y. H. pH-responsive sulfonamide/PEI system for tumor specific gene delivery: an in vitro study Biomacromolecules 2006, 7 (1) 64-70
28. Lee, E. S.; Gao, Z.; Bae, Y. H. Recent progress in tumor pH targeting nanotechnology J. Controlled Release 2008, 132 (3) 164-70
29. Lai, J. J.; Hoffman, J. M.; Ebara, M.; Hoffman, A. S.; Estournes, C.; Wattiaux, A.; Stayton, P. S. Dual magnetic-/temperature-responsive nanoparticles for microfluidic separations and assays Langmuir 2007, 23 (13) 7385-91
30. Veiseh, M.; Gabikian, P.; Bahrami, S. B.; Veiseh, O.; Zhang, M.; Hackman, R. C.; Ravanpay, A. C.; Stroud, M. R.; Kusuma, Y.; Hansen, S. J.; Kwok, D.; Munoz, N. M.; Sze, R. W.; Grady, W. M.; Greenberg, N. M.; Ellenbogen, R. G.; Olson, J. M. Tumor paint: a chlorotoxin:Cy5.5 bioconjugate for intraoperative visualization of cancer foci Cancer Res. 2007, 67 (14) 6882-8
31. Oh, I. K.; Mok, H.; Park, T. G. Folate immobilized and PEGylated adenovirus for retargeting to tumor cells Bioconjugate Chem. 2006, 17 (3) 721-7
32. Park, J.; An, K.; Hwang, Y.; Park, J. G.; Noh, H. J.; Kim, J. Y.; Park, J. H.; Hwang, N. M.; Hyeon, T. Ultra-large-scale syntheses of monodisperse nanocrystals Nat. Mater. 2004, 3 (12) 891-5
33. Deshane, J.; Garner, C. C.; Sontheimer, H. Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2 J. Biol. Chem. 2003, 278 (6) 4135-44
34. Riemer, J.; Hoepken, H. H.; Czerwinska, H.; Robinson, S. R.; Dringen, R. Colorimetric ferrozine-based assay for the quantitation of iron in cultured cells Anal. Biochem. 2004, 331 (2) 370-5
35. Veiseh, O.; Sun, C.; Gunn, J.; Kohler, N.; Gabikian, P.; Lee, D.; Bhattarai, N.; Ellenbogen, R.; Sze, R.; Hallahan, A.; Olson, J.; Zhang, M. Optical and MRI multifunctional nanoprobe for targeting gliomas Nano Lett. 2005, 5 (6) 1003-8
36. Shen, S.; Khazaeli, M. B.; Gillespie, G. Y.; Alvarez, V. L. Radiation dosimetry of 131I-chlorotoxin for targeted radiotherapy in glioma-bearing mice J. Neurooncol. 2005, 71 (2) 113-9
37. Pernodet, N.; Maaloum, M.; Tinland, B. Pore size of agarose gels by atomic force microscopy Electrophoresis 1997, 18 (1) 55-8
38. Chiche, J.; Ilc, K.; Laferriere, J.; Trottier, E.; Dayan, F.; Mazure, N. M.; Brahimi-Horn, M. C.; Pouyssegur, J. Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH Cancer Res. 2009, 69 (1) 358-68
39. Mok, H.; Park, T. G. Self-crosslinked and reducible fusogenic peptides for intracellular delivery of siRNA Biopolymers 2008, 89 (10) 881-8
40. Gupta, A. K.; Gupta, M. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications Biomaterials 2005, 26 (18) 3995-4021
41. Nie, S.; Xing, Y.; Kim, G. J.; Simons, J. W. Nanotechnology applications in cancer Annu. Rev. Biomed. Eng. 2007, 9, 257-88
42. Yezhelyev, M. V.; Qi, L.; O'Regan, R. M.; Nie, S.; Gao, X. Proton-sponge coated quantum dots for siRNA delivery and intracellular imaging J. Am. Chem. Soc. 2008, 130 (28) 9006-12
43. You, J. O.; Auguste, D. T. Nanocarrier cross-linking density and pH sensitivity regulate intracellular gene transfer Nano Lett. 2009, 9 (12) 4467-73