Gene delivery in three-dimensional cell cultures by superparamagnetic nanoparticles

ACS Nano

Volumn 4, Issue 8, 2010, Pages 4733-4743

  Zhang, Haiyuan ^a   Lee, Moo Yeal ^b   Hogg, Michael G ^b   Dordick, Jonathan S ^a   Sharfstein, Susan T ^a,c  

^a RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^b Current Address: Solidus Biosciences   (United States)

^c STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

Cytotoxicity; Gene expression; Gene transfer; Magnetism; Silencing RNA

Indexed keywords

3-D CELL CULTURE; 3-D CULTURE SYSTEM; 3D CULTURE; CELLULAR ASSAYS; DRUG CANDIDATES; DRUG DISCOVERY; EXTERNAL MAGNETIC FIELD; GEL MATRIX; GENE DELIVERY; GENE EXPRESSION PATTERNS; GFP EXPRESSION; GREEN FLUORESCENT PROTEIN; IN-VIVO; MASS TRANSFER LIMITATION; PHARMACOLOGICAL AGENTS; POLYETHYLENIMINES; SILENCING RNA; SMALL MOLECULES; SUPERPARAMAGNETIC NANOPARTICLES; THREE DIMENSIONAL CELL CULTURE; THREE-DIMENSIONAL (3D); TOXIC EFFECT; TRANSFECTION EFFICIENCY;

CELL DEATH; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; MAGNETIC FIELDS; NANOMAGNETICS; NANOPARTICLES; NUCLEIC ACIDS; RNA; SUPERPARAMAGNETISM; THREE DIMENSIONAL; TOXICITY;

CELL CULTURE;

COLLAGEN; DRUG CARRIER; FERRIC ION; FERRIC OXIDE; NANOPARTICLE; POLYETHYLENEIMINE; SMALL INTERFERING RNA;

ANIMAL; ARTICLE; CELL STRAIN 3T3; CELL STRAIN HEK293; CHEMISTRY; CULTURE TECHNIQUE; GENE SILENCING; GENETIC TRANSFECTION; GENETICS; HUMAN; MAGNETISM; METABOLISM; METHODOLOGY; MOLECULAR WEIGHT; MOUSE; PLASMID;

ANIMALS; CELL CULTURE TECHNIQUES; COLLAGEN; DRUG CARRIERS; FERRIC COMPOUNDS; GENE SILENCING; HEK293 CELLS; HUMANS; MAGNETICS; MICE; MOLECULAR WEIGHT; NANOPARTICLES; NIH 3T3 CELLS; PLASMIDS; POLYETHYLENEIMINE; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 78650162136     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn9018812     Document Type: Article

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