In vivo cancer targeting and imaging with semiconductor quantum dots

Nature Biotechnology

Volumn 22, Issue 8, 2004, Pages 969-976

  Gao, Xiaohu ^a   Cui, Yuanyuan ^b   Levenson, Richard M ^c   Chung, Leland W K ^b   Nie, Shuming ^a  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Cambridge Research & Instrumentation Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; BIOMARKERS; COPOLYMERS; IMAGING TECHNIQUES; NANOSTRUCTURED MATERIALS; TUMORS;

AMPHIPHILIC POLYMERS; TRIBLOCK COPOLYMERS;

SEMICONDUCTOR QUANTUM DOTS;

AMPHOPHILE; ANTIBODY; BIOLOGICAL MARKER; CADMIUM DERIVATIVE; CADMIUM SELENIDE; CELL SURFACE MARKER; COPOLYMER; LIGAND; NANOPARTICLE; POLY(BUTYL ACRYLATE); POLY(ETHYL ACRYLATE); POLYMETHACRYLIC ACID; QUANTUM DOT; TRIOCTYLPHOSPHINE OXIDE; UNCLASSIFIED DRUG; ZINC SULFIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN BINDING; ARTICLE; CANCER; CANCER CELL CULTURE; CANCER LOCALIZATION; CANCER MODEL; COLOR; DIAGNOSTIC ACCURACY; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; DRUG ACCUMULATION; DRUG DESIGN; DRUG PENETRATION; DRUG RETENTION; DRUG TARGETING; FLUORESCENCE; HUMAN; HUMAN CELL; ILLUMINATION; IMAGE ANALYSIS; LUMINESCENCE; MOUSE; NANOTECHNOLOGY; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; QUANTUM CHEMISTRY; SEMICONDUCTOR; SPECTRAL SENSITIVITY; SPECTROSCOPY;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; COATED MATERIALS, BIOCOMPATIBLE; DRUG DELIVERY SYSTEMS; FEMALE; HUMANS; IMAGE ENHANCEMENT; MALE; MATERIALS TESTING; MICE; MICE, NUDE; MICROSCOPY, FLUORESCENCE; NEOPLASMS; PROSTATIC NEOPLASMS; QUANTUM DOTS; SEMICONDUCTORS; SPECTROMETRY, FLUORESCENCE; TISSUE DISTRIBUTION;

ANIMALIA; MUS MUSCULUS;

EID: 3543022686     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt994     Document Type: Article

References (56)

1. Chan, W.C.W. et al. Luminescent QDs for multiplexed biological detection and imaging. Curr. Opin. Biotechnol. 13, 40-46 (2002).
2. Bruchez, M., Jr, Moronne, M., Gin, P., Weiss, S. & Alivisatos, A.P. Semiconductor nanocrystals as fluorescent biological labels. Science 281, 2013-2015 (1998).
3. Chan, W.C.W. & Nie, S.M. Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science 281, 2016-2018 (1998).
4. Mattoussi, H. et al. Self-assembly of CdSe-ZnS quantum dot bioconjugates using an engineered recombinant protein. J. Am. Chem. Soc. 122, 12142-12150 (2000).
5. Akerman, M.E., Chan, W.C.W., Laakkonen, P., Bhatia, S.N. & Ruoslahti, E. Nanocrystal targeting in vivo. Proc. Natl. Acad. Sci. USA 99, 12617-12621 (2002).
6. Dubertret, B. et al. In vivo imaging of QDs encapsulated in phospholipid micelles. Science 298, 1759-1762 (2002).
7. Wu, X.Y. et al. Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor QDs. Nat. Biotechnol. 21, 41-46 (2003).
8. Jaiswal, J.K., Mattoussi, H., Mauro, J.M. & Simon, S.M. Long-term multiple color imaging of live cells using quantum dot bioconjugates. Nat. Biotechnol. 21, 47-51 (2003).
9. Larson, D.R. et al. Water-soluble quantum dots for multiphoton fluorescence imaging in vivo. Science 300, 1434-1436 (2003).
10. Ishii, D. et al. Chaperonin-mediated stabilization and ATP-triggered release of semiconductor nanoparticles. Nature 423, 628-632 (2003).
11. Medintz, I.L. et al. Self-assembled nanoscale biosensors based on quantum dot FRET donors. Nat. Mater. 2, 630-639 (2003).
12. Dahan, M. et al. Diffusion dynamics of glycine receptors revealed by single-quantum dot tracking. Science 302, 442-445 (2003).
13. Rosenthal, S.J. et al. Targeting cell surface receptors with ligand-conjugated nanocrystals. J. Am. Chem. Soc. 124, 4586-4594 (2002).
14. Niemeyer, C.M. Nanoparticles, Proteins, and nucleic acids: biotechnology meets materials science. Angew. Chem. Int. Ed. Engl. 40, 4128-4158 (2001).
15. Alivisatos, A.P. Semiconductor clusters, nanocrystals, and quantum dots. Science 271, 933-937 (1996).
16. Han, M.Y., Gao, X.H., Su, J.Z. & Nie, S.M. Quantum dot-tagged microbeads for multiplexed optical coding of biomolecules. Nat. Biotechnol. 19, 631-635 (2001).
17. Gao, X.H. & Nie, S.M. Doping mesoporous materials with multicolor quantum dots. J. Phys. Chem. B. 107, 11575-11578 (2003).
18. Gao, X.H. & Nie, S.M. Quantum dot-encoded mesoporous beads with high brightness and uniformity: rapid readout using flow cytometry. Anal. Chem. 76, 2406-2410 (2004).
19. Josephson, L., Kircher, M.F., Mahmood, U., Tang, Y. & Weissleder, R. Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes. Bioconjug. Chem. 13, 554-560 (2002).
20. Gao, X.H. & Nie, S.M. Molecular profiling of single cells and tissue specimens with quantum dots. Trends Biotechnol. 21, 371-373 (2003).
21. Jovin, T.M. Quantum dots finally come of age. Nat. Biotechnol. 21, 32-33 (2003).
22. Lim, Y.T. et al. Selection of quantum dot wavelengths for biomedical assays and imaging. Mol. Imaging 2, 50-64 (2003).
23. Ballou, B., Lagerholm, B.C., Ernst, L.A., Bruchez, M.P. & Waggoner, A.S. Noninvasive imaging of quantum dots in mice. Bioconjug. Chem. 15, 79-86 (2004).
24. Kim, S. et al. Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping. Nat. Biotechnol. 22, 93-95 (2004).
25. Lidke, D.S. et al. Quantum dot ligands provide new insights into erbB/HER receptor-mediated signal transduction. Nat. Biotechnol. 22, 198-20 (2004).
26. Savic, R., Luo, L.B., Eisenberg, A. & Maysinger, D. Micellar nanocontainers distribute to defined cytoplasmic organelles. Science 300, 615-618 (2003).
27. Allen, C., Maysinger, D. & Eisenberg, A. Nano-engineering block copolymer aggregates for drug delivery. Colloids Surf. B Biointerfaces 16, 3-27 (1999).
28. Ludwigs, S. et al. Self-assembly of functional nanostructure from ABC triblock copolymers. Nat. Mater. 2, 744-747 (2003).
29. Ness, J.M., Akhtar, R.S., Latham, C.B. & Roth, K.A. Combined tyramide signal amplification and quantum dots for sensitive and photostable immunofluorescence detection. J. Histochem. Cytochem. 51, 981-987 (2003).
30. Nirmal, M. et al. Fluorescence intermittency in single cadmium Selenide nanocrystals Nature 383, 802-804 (1996).
31. Empedocles, S.A. & Bawendi, M.G. Quantum-confined stark effect in single CdSe nanocrystallite quantum dots. Science 278, 2114-2117 (1997).
32. Kirpotin, D. et al. Sterically stabilized anti-HER2 immunolipasomes: design and targeting to human breast cancer cell in vitro. Biochemistry 36, 66-75 (1997).
33. Duncan, R. The dawning era of polymer therapeutics. Nat. Rev. Drug Discov. 2, 347-360 (2003).
34. Jain, R.K. Transport of molecules, particles, and cells in solid tumors. Ann. Rev. Biomed. Eng. 1, 241-263 (1999).
35. Jain, R.K. Delivery of molecular medicine to solid tumors: lessons from in vivo imaging of gene expression and function. J. Control. Release 74, 7-25 (2001).
36. Chang, S.S., Reuter, V.E., Heston, W.D.W. & Gaudin, P.B. Metastatic renal cell carcinoma neovasculature expresses prostate-specific membrane antigen Urology 57, 801-805 (2001).
37. Schulke, N. et al. The homodimer of prostate-specific membrane antigen is a functional target for cancer therapy. Proc. Natl. Acad. Sci. USA 100, 12590-12595 (2003).
38. Bander, N.H. et al. Targeting metastatic prostate cancer with radiolabeled monoclonal antibody J591 to the extracellular domain of prostate specific membrane antigen. J. Urol. 170, 1717-1721 (2003).
39. Wunderbaldinger, P., Josephson, L. & Weissleder, R. Tat peptide directs enhanced clearance and hepatic permeability of magnetic nanoparticles. Bioconjug. Chem. 13, 264-268 (2002).
40. Campbell, R.B. et al. Cationic Charge Determines the Distribution of Liposomes between the Vascular and Extravascular Compartments of Tumors. Cancer Res. 62, 6831-6836 (2002).
41. Levenson, R.M. Spectral imaging and pathology: seeing more Lab. Med. 35, 244-251 (2004).
42. Yang, M. et al. Direct external imaging of nascent cancer, tumor progression, angiogenesis, and metastasis on internal organs in the fluorescent orthotopic model. Proc. Natl. Acad. Sci. USA 99, 3824-3829 (2002).
43. Lewin, M. el al. Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells. Nat. Biotechnol 18, 410-414 (2000).
44. Randolph G.J., Inaba, K., Robbiani, D.F., Steinman, R.M. & Muller W.A. Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo. Immunity 11, 753-761 (1999).
45. Hess, B.C. et al. Surface transformation and photoinduced recovery in CdSe nanocrystals. Phys. Rev. Lett. 86, 3132-3135 (2001).
46. Manna, L., Scher, E.C., Li, L.-S. & Alivisatos A.P. Epitaxial growth, and photochemical annealing of graded CdS/ZnS shells on colloidal CdSe nanorods. J. Am. Chem. Soc. 124, 7136-7145 (2002).
47. Mammen, M., Choi, S.K. & Whitesides, G.M. Polyvalent interactions in biological systems: implications for design and use of multivalent ligands and inhibitors. Angew. Chem. Int. Edn Engl. 37, 2754-2794 (1998).
48. Jin, R., Wu, G., Li, Z. & Mirkin, C.A. & and Schatz, G.C. What controls the melting properties of DNA-linked gold nanoparticle assemblies. J. Am. Chem. Soc. 125, 1643-1654 (2003).
49. Cheong, W.F., Prahl, S.A. & Welch, A.J. A review of the optical properties of biological tissues. IEEE J. Quantum Electron. 26, 2166-2185 (1990).
50. Ntziachristos, V., Bremer, C. & Weissleder, R. Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging. Eur. Radiol. 13, 195-208 (2003).
51. Bailey, R.E. & Nie, S.M. Alloyed semiconductor QDs: tuning the practical properties without changing the particle size. J. Am. Chem. Soc. 125, 7100-7106 (2003).
52. Kim, S., Fisher, B., Eisler, H.J. & Bawendi, M.G. Type-II quantum dots: CdTe/CdSe (core/shell) and CdSe/ZnTe (core/shell) heterostructures. J. Am. Chem. Soc. 125, 11466-11467 (2003).
53. Derfus, A.M., Chan, W.C.W. & Bhatia, S.N. Probing the cytotoxicity of semiconductor quantum dots. Nano Lett. 4, 11-18 (2004).
54. Peng, Z.A. & Peng, X. Formation of high-quality CdTe, CdSe and CdS nanocrystals using CdO as precursor. J. Am. Chem. Soc. 123, 183-184 (2001).
55. Qu, L.H., Peng, Z.A. & Peng, X. Alternative routes toward high quality CdSe nanocrystals. Nano Lett. 1, 333-337 (2001).
56. Hsieh, C.L. et al. Improved gene-expression by a modified bicistronic retroviral vector. Biochem. Bioph. Res. Commun. 214, 910-917 (1995).