메뉴 건너뛰기




Volumn 333, Issue 2, 2005, Pages 328-335

Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy

Author keywords

Angiogenesis; Chemotherapy; Endothelium; Monoclonal antibodies; Tumor; VEGF

Indexed keywords

AG 013676; BEVACIZUMAB; CAPECITABINE; CARBOPLATIN; FLUOROURACIL; FOLINIC ACID; MONOCLONAL ANTIBODY; OXALIPLATIN; PACLITAXEL; PROTEIN TYROSINE KINASE INHIBITOR; SUNITINIB; UNCLASSIFIED DRUG; VASCULOTROPIN A; VASCULOTROPIN ANTIBODY; VASCULOTROPIN RECEPTOR; VATALANIB;

EID: 20544455330     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.05.132     Document Type: Review
Times cited : (851)

References (96)
  • 1
    • 0036782278 scopus 로고    scopus 로고
    • VEGF and the quest for tumour angiogenesis factors
    • N. Ferrara VEGF and the quest for tumour angiogenesis factors Nat. Rev. Cancer 2 2002 795 803
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 795-803
    • Ferrara, N.1
  • 2
    • 0000912662 scopus 로고
    • Vascularization of the Brown Pearce rabbit epithelioma transplant as seen in the transparent ear chamber
    • A.G. Ide, N.H. Baker, and S.L. Warren Vascularization of the Brown Pearce rabbit epithelioma transplant as seen in the transparent ear chamber Am. J. Roentgenol. 42 1939 891 899
    • (1939) Am. J. Roentgenol. , vol.42 , pp. 891-899
    • Ide, A.G.1    Baker, N.H.2    Warren, S.L.3
  • 3
    • 0014304893 scopus 로고
    • Tumor angiogenesis: Transfilter diffusion studies in the hamster by the transparentchamber technique
    • M. Greenblatt, and P. Shubick Tumor angiogenesis: transfilter diffusion studies in the hamster by the transparentchamber technique J. Natl. Cancer Inst. 41 1968 111 124
    • (1968) J. Natl. Cancer Inst. , vol.41 , pp. 111-124
    • Greenblatt, M.1    Shubick, P.2
  • 4
    • 0014365361 scopus 로고
    • Choriocarcinoma. Transfilter stimulation of vasoproliferation in the hamster cheek pouch. Studied by light and electron microscopy
    • R.L. Ehrmann, and M. Knoth Choriocarcinoma. Transfilter stimulation of vasoproliferation in the hamster cheek pouch. Studied by light and electron microscopy J. Natl. Cancer Inst. 41 1968 1329 1341
    • (1968) J. Natl. Cancer Inst. , vol.41 , pp. 1329-1341
    • Ehrmann, R.L.1    Knoth, M.2
  • 5
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • J. Folkman Tumor angiogenesis: therapeutic implications N. Engl. J. Med. 285 1971 1182 1186
    • (1971) N. Engl. J. Med. , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 8
    • 2442621619 scopus 로고    scopus 로고
    • Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
    • N. Ferrara, K.J. Hillan, H.P. Gerber, and W. Novotny Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer Nat. Rev. Drug Discov. 3 2004 391 400
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 391-400
    • Ferrara, N.1    Hillan, K.J.2    Gerber, H.P.3    Novotny, W.4
  • 9
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • D.R. Senger, S.J. Galli, A.M. Dvorak, C.A. Perruzzi, V.S. Harvey, and H.F. Dvorak Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid Science 219 1983 983 985
    • (1983) Science , vol.219 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3    Perruzzi, C.A.4    Harvey, V.S.5    Dvorak, H.F.6
  • 10
    • 0024384470 scopus 로고
    • Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
    • N. Ferrara, and W.J. Henzel Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells Biochem. Biophys. Res. Commun. 1989 851 858
    • (1989) Biochem. Biophys. Res. Commun. , pp. 851-858
    • Ferrara, N.1    Henzel, W.J.2
  • 12
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • D.W. Leung, G. Cachianes, W.J. Kuang, D.V. Goeddel, and N. Ferrara Vascular endothelial growth factor is a secreted angiogenic mitogen Science 246 1989 1306 1309
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3    Goeddel, D.V.4    Ferrara, N.5
  • 14
    • 0026395163 scopus 로고
    • The vascular endothelial growth factor family: Identification of a fourth molecular species and characterization of alternative splicing of RNA
    • K.A. Houck, N. Ferrara, J. Winer, G. Cachianes, B. Li, and D.W. Leung The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA Mol. Endocrinol. 5 1991 1806 1814
    • (1991) Mol. Endocrinol. , vol.5 , pp. 1806-1814
    • Houck, K.A.1    Ferrara, N.2    Winer, J.3    Cachianes, G.4    Li, B.5    Leung, D.W.6
  • 15
    • 0025999033 scopus 로고
    • The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing
    • E. Tischer, R. Mitchell, T. Hartman, M. Silva, D. Gospodarowicz, J.C. Fiddes, and J.A. Abraham The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing J. Biol. Chem. 266 1991 11947 11954
    • (1991) J. Biol. Chem. , vol.266 , pp. 11947-11954
    • Tischer, E.1    Mitchell, R.2    Hartman, T.3    Silva, M.4    Gospodarowicz, D.5    Fiddes, J.C.6    Abraham, J.A.7
  • 16
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Basic science and clinical progress
    • N. Ferrara Vascular endothelial growth factor: basic science and clinical progress Endocr. Rev. 25 2004 581 611
    • (2004) Endocr. Rev. , vol.25 , pp. 581-611
    • Ferrara, N.1
  • 17
    • 0027064888 scopus 로고
    • Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms
    • K.A. Houck, D.W. Leung, A.M. Rowland, J. Winer, and N. Ferrara Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms J. Biol. Chem 267 1992 26031 26037
    • (1992) J. Biol. Chem , vol.267 , pp. 26031-26037
    • Houck, K.A.1    Leung, D.W.2    Rowland, A.M.3    Winer, J.4    Ferrara, N.5
  • 18
    • 0027751890 scopus 로고
    • The vascular endothelial growth factor isoforms (VEGF): Differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF
    • J.E. Park, G.-A. Keller, and N. Ferrara The vascular endothelial growth factor isoforms (VEGF): differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF Mol. Biol. Cell 4 1993 1317 1326
    • (1993) Mol. Biol. Cell , vol.4 , pp. 1317-1326
    • Park, J.E.1    Keller, G.-A.2    Ferrara, N.3
  • 19
    • 0029937679 scopus 로고    scopus 로고
    • The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potency
    • B.A. Keyt, L.T. Berleau, H.V. Nguyen, H. Chen, H. Heinsohn, R. Vandlen, and N. Ferrara The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potency J. Biol. Chem. 271 1996 7788 7795
    • (1996) J. Biol. Chem. , vol.271 , pp. 7788-7795
    • Keyt, B.A.1    Berleau, L.T.2    Nguyen, H.V.3    Chen, H.4    Heinsohn, H.5    Vandlen, R.6    Ferrara, N.7
  • 21
    • 0032515047 scopus 로고    scopus 로고
    • VEGF regulates endothelial cell survival by the PI3-kinase/Akt signal transduction Pathway. requirement for Flk-1/KDR activation
    • H.P. Gerber, A. McMurtrey, J. Kowalski, M. Yan, B.A. Keyt, V. Dixit, and N. Ferrara VEGF regulates endothelial cell survival by the PI3-kinase/Akt signal transduction Pathway. requirement for Flk-1/KDR activation J. Biol. Chem. 273 1998 30343 30366
    • (1998) J. Biol. Chem. , vol.273 , pp. 30343-30366
    • Gerber, H.P.1    McMurtrey, A.2    Kowalski, J.3    Yan, M.4    Keyt, B.A.5    Dixit, V.6    Ferrara, N.7
  • 22
    • 0032557564 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells
    • H.P. Gerber, V. Dixit, and N. Ferrara Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells J. Biol. Chem. 273 1998 13313 13316
    • (1998) J. Biol. Chem. , vol.273 , pp. 13313-13316
    • Gerber, H.P.1    Dixit, V.2    Ferrara, N.3
  • 23
    • 0029949160 scopus 로고    scopus 로고
    • Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody
    • F. Yuan, Y. Chen, M. Dellian, N. Safabakhsh, N. Ferrara, and R.K. Jain Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody Proc. Natl. Acad. Sci. USA 93 1996 14765 14770
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 14765-14770
    • Yuan, F.1    Chen, Y.2    Dellian, M.3    Safabakhsh, N.4    Ferrara, N.5    Jain, R.K.6
  • 24
    • 0032952010 scopus 로고    scopus 로고
    • Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
    • L.E. Benjamin, D. Golijanin, A. Itin, D. Pode, and E. Keshet Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal J. Clin. Invest. 103 1999 159 165
    • (1999) J. Clin. Invest. , vol.103 , pp. 159-165
    • Benjamin, L.E.1    Golijanin, D.2    Itin, A.3    Pode, D.4    Keshet, E.5
  • 25
    • 0036842215 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
    • H.F. Dvorak Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy J. Clin. Oncol. 20 2002 4368 4380
    • (2002) J. Clin. Oncol. , vol.20 , pp. 4368-4380
    • Dvorak, H.F.1
  • 26
    • 0041378074 scopus 로고    scopus 로고
    • Blood vessels and nerves: Common signals, pathways and diseases
    • P. Carmeliet Blood vessels and nerves: common signals, pathways and diseases Nat. Rev. Genet. 4 2003 710 720
    • (2003) Nat. Rev. Genet. , vol.4 , pp. 710-720
    • Carmeliet, P.1
  • 27
    • 0025259592 scopus 로고
    • Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase (flt) closely related to the fms family
    • M. Shibuya, S. Yamaguchi, A. Yamane, T. Ikeda, A. Tojo, H. Matsushime, and M. Sato Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase (flt) closely related to the fms family Oncogene 8 1990 519 527
    • (1990) Oncogene , vol.8 , pp. 519-527
    • Shibuya, M.1    Yamaguchi, S.2    Yamane, A.3    Ikeda, T.4    Tojo, A.5    Matsushime, H.6    Sato, M.7
  • 28
    • 0026572345 scopus 로고
    • The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor
    • C. de Vries, J.A. Escobedo, H. Ueno, K. Houck, N. Ferrara, and L.T. Williams The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor Science 255 1992 989 991
    • (1992) Science , vol.255 , pp. 989-991
    • De Vries, C.1    Escobedo, J.A.2    Ueno, H.3    Houck, K.4    Ferrara, N.5    Williams, L.T.6
  • 30
    • 0027466849 scopus 로고
    • High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis
    • B. Millauer, S. Wizigmann Voos, H. Schnurch, R. Martinez, N.P. Moller, W. Risau, and A. Ullrich High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis Cell 72 1993 835 846 Issue No: 0092-8674.
    • (1993) Cell , vol.72 , pp. 835-846
    • Millauer, B.1    Wizigmann Voos, S.2    Schnurch, H.3    Martinez, R.4    Moller, N.P.5    Risau, W.6    Ullrich, A.7
  • 31
    • 0027249239 scopus 로고
    • Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium
    • T.P. Quinn, K.G. Peters, C. De Vries, N. Ferrara, and L.T. Williams Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium Proc. Natl. Acad. Sci. USA 90 1993 7533 7537
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 7533-7537
    • Quinn, T.P.1    Peters, K.G.2    De Vries, C.3    Ferrara, N.4    Williams, L.T.5
  • 32
    • 0028134936 scopus 로고
    • Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR
    • J.E. Park, H.H. Chen, J. Winer, K.A. Houck, and N. Ferrara Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR J. Biol. Chem. 269 1994 25646 25654
    • (1994) J. Biol. Chem. , vol.269 , pp. 25646-25654
    • Park, J.E.1    Chen, H.H.2    Winer, J.3    Houck, K.A.4    Ferrara, N.5
  • 34
    • 0037182861 scopus 로고    scopus 로고
    • Vascular endothelial growth factor regulates hematopoietic stem cell survival by an internal autocrine loop mechanism
    • H.-P. Gerber, A. Malik, G.P. Solar, D. Sherman, X.-H. Liang, G. Meng, K. Hong, J. Marsters, and N. Ferrara Vascular endothelial growth factor regulates hematopoietic stem cell survival by an internal autocrine loop mechanism Nature 417 2002 954 958
    • (2002) Nature , vol.417 , pp. 954-958
    • Gerber, H.-P.1    Malik, A.2    Solar, G.P.3    Sherman, D.4    Liang, X.-H.5    Meng, G.6    Hong, K.7    Marsters, J.8    Ferrara, N.9
  • 35
    • 0029867554 scopus 로고    scopus 로고
    • Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1
    • B. Barleon, S. Sozzani, D. Zhou, H.A. Weich, A. Mantovani, and D. Marme Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1 Blood 87 1996 3336 3343
    • (1996) Blood , vol.87 , pp. 3336-3343
    • Barleon, B.1    Sozzani, S.2    Zhou, D.3    Weich, H.A.4    Mantovani, A.5    Marme, D.6
  • 39
    • 0032549799 scopus 로고    scopus 로고
    • Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
    • S. Soker, S. Takashima, H.Q. Miao, G. Neufeld, and M. Klagsbrun Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor Cell 92 1998 735 745
    • (1998) Cell , vol.92 , pp. 735-745
    • Soker, S.1    Takashima, S.2    Miao, H.Q.3    Neufeld, G.4    Klagsbrun, M.5
  • 40
    • 0037362890 scopus 로고    scopus 로고
    • HIF hydroxylation and the mammalian oxygen-sensing pathway
    • M. Safran, and W.J. Kaelin Jr. HIF hydroxylation and the mammalian oxygen-sensing pathway J. Clin. Invest. 111 2003 779 783
    • (2003) J. Clin. Invest. , vol.111 , pp. 779-783
    • Safran, M.1    Kaelin Jr., W.J.2
  • 41
    • 0036138398 scopus 로고    scopus 로고
    • Regulation of HIF by the von Hippel-Lindau tumour suppressor: Implications for cellular oxygen sensing
    • D.R. Mole, P.H. Maxwell, C.W. Pugh, and P.J. Ratcliffe Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing IUBMB Life 52 2001 43 47
    • (2001) IUBMB Life , vol.52 , pp. 43-47
    • Mole, D.R.1    Maxwell, P.H.2    Pugh, C.W.3    Ratcliffe, P.J.4
  • 46
    • 0028834638 scopus 로고
    • Both v-Ha-Ras and v-Raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells
    • S. Grugel, G. Finkenzeller, K. Weindel, B. Barleon, and D. Marme Both v-Ha-Ras and v-Raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells J. Biol. Chem. 270 1995 25915 25919
    • (1995) J. Biol. Chem. , vol.270 , pp. 25915-25919
    • Grugel, S.1    Finkenzeller, G.2    Weindel, K.3    Barleon, B.4    Marme, D.5
  • 47
    • 0032584108 scopus 로고    scopus 로고
    • Impact of oncogenes in tumor angiogenesis: Mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells
    • F. Okada, J.W. Rak, B.S. Croix, B. Lieubeau, M. Kaya, L. Roncari, S. Shirasawa, T. Sasazuki, and R.S. Kerbel Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells Proc. Natl. Acad. Sci. USA 95 1998 3609 3614
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 3609-3614
    • Okada, F.1    Rak, J.W.2    Croix, B.S.3    Lieubeau, B.4    Kaya, M.5    Roncari, L.6    Shirasawa, S.7    Sasazuki, T.8    Kerbel, R.S.9
  • 48
    • 0033582259 scopus 로고    scopus 로고
    • Oncogenic ras fails to restore an in vivo oncogenic phenotype in embryonic stem cells lacking VEGF
    • Y.-P. Shi, and N. Ferrara Oncogenic ras fails to restore an in vivo oncogenic phenotype in embryonic stem cells lacking VEGF Biochem. Biophys. Res. Commun. 254 1999 480 483
    • (1999) Biochem. Biophys. Res. Commun. , vol.254 , pp. 480-483
    • Shi, Y.-P.1    Ferrara, N.2
  • 49
    • 0035882030 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia
    • X. Zhang, J.P. Gaspard, and D.C. Chung Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia Cancer Res. 61 2001 6050 6054
    • (2001) Cancer Res. , vol.61 , pp. 6050-6054
    • Zhang, X.1    Gaspard, J.P.2    Chung, D.C.3
  • 50
    • 1842328560 scopus 로고    scopus 로고
    • Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer
    • M. Volm, R. Koomagi, and J. Mattern Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer Int. J. Cancer 74 1997 64 68
    • (1997) Int. J. Cancer , vol.74 , pp. 64-68
    • Volm, M.1    Koomagi, R.2    Mattern, J.3
  • 51
    • 0029935566 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer
    • H. Yoshiji, D.E. Gomez, M. Shibuya, and U.P. Thorgeirsson Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer Cancer Res. 56 1996 2013 2016
    • (1996) Cancer Res. , vol.56 , pp. 2013-2016
    • Yoshiji, H.1    Gomez, D.E.2    Shibuya, M.3    Thorgeirsson, U.P.4
  • 52
  • 54
    • 0031458922 scopus 로고    scopus 로고
    • Expression and localization of the vascular endothelial growth factor family in ovarian epithelial tumors
    • H.M. Sowter, A.N. Corps, A.L. Evans, D.E. Clark, D.S. Charnock-Jones, and S.K. Smith Expression and localization of the vascular endothelial growth factor family in ovarian epithelial tumors Lab. Invest 77 1997 607 614
    • (1997) Lab. Invest , vol.77 , pp. 607-614
    • Sowter, H.M.1    Corps, A.N.2    Evans, A.L.3    Clark, D.E.4    Charnock-Jones, D.S.5    Smith, S.K.6
  • 55
    • 3142587052 scopus 로고    scopus 로고
    • Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes
    • J. Brugarolas, and W.G. Kaelin Jr. Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes Cancer Cell 6 2004 7 10
    • (2004) Cancer Cell , vol.6 , pp. 7-10
    • Brugarolas, J.1    Kaelin Jr., W.G.2
  • 56
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo
    • K.J. Kim, B. Li, J. Winer, M. Armanini, N. Gillett, H.S. Phillips, and N. Ferrara Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo Nature 362 1993 841 844
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3    Armanini, M.4    Gillett, N.5    Phillips, H.S.6    Ferrara, N.7
  • 57
    • 0028935608 scopus 로고
    • Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis
    • R.S. Warren, H. Yuan, M.R. Matli, N.A. Gillett, and N. Ferrara Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis J. Clin. Invest. 95 1995 1789 1797
    • (1995) J. Clin. Invest. , vol.95 , pp. 1789-1797
    • Warren, R.S.1    Yuan, H.2    Matli, M.R.3    Gillett, N.A.4    Ferrara, N.5
  • 58
    • 0030059075 scopus 로고    scopus 로고
    • Vascular endothelial growth factor promotes tumor dissemination by a mechanism distinct from its effect on primary tumor growth
    • O. Melnyk, M.A. Shuman, and K.J. Kim Vascular endothelial growth factor promotes tumor dissemination by a mechanism distinct from its effect on primary tumor growth Cancer Res. 56 1996 921 924
    • (1996) Cancer Res. , vol.56 , pp. 921-924
    • Melnyk, O.1    Shuman, M.A.2    Kim, K.J.3
  • 59
    • 0029816983 scopus 로고    scopus 로고
    • Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: Novel concepts of angiostatic therapy from intravital videomicroscopy
    • P. Borgstrom, K.J. Hillan, P. Sriramarao, and N. Ferrara Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: novel concepts of angiostatic therapy from intravital videomicroscopy Cancer Res. 56 1996 4032 4039
    • (1996) Cancer Res. , vol.56 , pp. 4032-4039
    • Borgstrom, P.1    Hillan, K.J.2    Sriramarao, P.3    Ferrara, N.4
  • 60
    • 0031898292 scopus 로고    scopus 로고
    • Neutralizing anti-vascular endothelial growth factor antibody completely inhibits angiogenesis and growth of human prostate carcinoma micro tumors in vivo
    • P. Borgstrom, M.A. Bourdon, K.J. Hillan, P. Sriramarao, and N. Ferrara Neutralizing anti-vascular endothelial growth factor antibody completely inhibits angiogenesis and growth of human prostate carcinoma micro tumors in vivo Prostate 35 1998 1 10
    • (1998) Prostate , vol.35 , pp. 1-10
    • Borgstrom, P.1    Bourdon, M.A.2    Hillan, K.J.3    Sriramarao, P.4    Ferrara, N.5
  • 61
    • 0028824336 scopus 로고
    • Inhibition of tumor growth and metastasis by an immunoneutralizing monoclonal antibody to human vascular endothelial growth factor/vascular permeability factor121
    • M. Asano, A. Yukita, T. Matsumoto, S. Kondo, and H. Suzuki Inhibition of tumor growth and metastasis by an immunoneutralizing monoclonal antibody to human vascular endothelial growth factor/vascular permeability factor121 Cancer Res. 55 1995 5296 5301
    • (1995) Cancer Res. , vol.55 , pp. 5296-5301
    • Asano, M.1    Yukita, A.2    Matsumoto, T.3    Kondo, S.4    Suzuki, H.5
  • 62
    • 0028174337 scopus 로고
    • Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant
    • B. Millauer, L.K. Shawver, K.H. Plate, W. Risau, and A. Ullrich Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant Nature 367 1994 576 579
    • (1994) Nature , vol.367 , pp. 576-579
    • Millauer, B.1    Shawver, L.K.2    Plate, K.H.3    Risau, W.4    Ullrich, A.5
  • 66
    • 0032530218 scopus 로고    scopus 로고
    • Tumor growth modulation by sense and antisense vascular endothelial growth factor gene expression: Effects on angiogenesis, vascular permeability, blood volume, blood flow, fluorodeoxyglucose uptake, and proliferation of human melanoma intracerebral xenografts
    • T. Oku, J.G. Tjuvajev, T. Miyagawa, T. Sasajima, A. Joshi, R. Joshi, R. Finn, K.P. Claffey, and R.G. Blasberg Tumor growth modulation by sense and antisense vascular endothelial growth factor gene expression: effects on angiogenesis, vascular permeability, blood volume, blood flow, fluorodeoxyglucose uptake, and proliferation of human melanoma intracerebral xenografts Cancer Res. 58 1998 4185 4192
    • (1998) Cancer Res. , vol.58 , pp. 4185-4192
    • Oku, T.1    Tjuvajev, J.G.2    Miyagawa, T.3    Sasajima, T.4    Joshi, A.5    Joshi, R.6    Finn, R.7    Claffey, K.P.8    Blasberg, R.G.9
  • 68
    • 0033708398 scopus 로고    scopus 로고
    • Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor
    • H.P. Gerber, J. Kowalski, D. Sherman, D.A. Eberhard, and N. Ferrara Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor Cancer Res. 60 2000 6253 6258
    • (2000) Cancer Res. , vol.60 , pp. 6253-6258
    • Gerber, H.P.1    Kowalski, J.2    Sherman, D.3    Eberhard, D.A.4    Ferrara, N.5
  • 72
    • 0034087691 scopus 로고    scopus 로고
    • Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity
    • G. Klement, S. Baruchel, J. Rak, S. Man, K. Clark, D.J. Hicklin, P. Bohlen, and R.S. Kerbel Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity J. Clin. Invest. 105 2000 R15 R24
    • (2000) J. Clin. Invest. , vol.105
    • Klement, G.1    Baruchel, S.2    Rak, J.3    Man, S.4    Clark, K.5    Hicklin, D.J.6    Bohlen, P.7    Kerbel, R.S.8
  • 74
    • 0035132923 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts
    • S.V. Kozin, Y. Boucher, D.J. Hicklin, P. Bohlen, R.K. Jain, and H.D. Suit Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts Cancer Res. 61 2001 39 44
    • (2001) Cancer Res. , vol.61 , pp. 39-44
    • Kozin, S.V.1    Boucher, Y.2    Hicklin, D.J.3    Bohlen, P.4    Jain, R.K.5    Suit, H.D.6
  • 75
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
    • R.K. Jain Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy Nat. Med. 7 2001 987 989
    • (2001) Nat. Med. , vol.7 , pp. 987-989
    • Jain, R.K.1
  • 76
    • 0031946469 scopus 로고    scopus 로고
    • Magnetic resonance imaging detects suppression of tumor vascular permeability after administration of antibody to vascular endothelial growth factor
    • C.D. Pham, T.P. Roberts, N. van Bruggen, O. Melnyk, J. Mann, N. Ferrara, R.L. Cohen, and R.C. Brasch Magnetic resonance imaging detects suppression of tumor vascular permeability after administration of antibody to vascular endothelial growth factor Cancer Invest. 16 1998 225 230
    • (1998) Cancer Invest. , vol.16 , pp. 225-230
    • Pham, C.D.1    Roberts, T.P.2    Van Bruggen, N.3    Melnyk, O.4    Mann, J.5    Ferrara, N.6    Cohen, R.L.7    Brasch, R.C.8
  • 79
    • 0032530717 scopus 로고    scopus 로고
    • VEGF and the Fab fragment of a humanized neutralizing antibody: Crystal structure of the complex at 2.4 Å resolution and mutational analysis of the interface
    • Y.A. Muller, Y. Chen, H.W. Christinger, B. Li, B.C. Cunningham, H.B. Lowman, and A.M. de Vos VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 Å resolution and mutational analysis of the interface Structure 6 1998 1153 1167
    • (1998) Structure , vol.6 , pp. 1153-1167
    • Muller, Y.A.1    Chen, Y.2    Christinger, H.W.3    Li, B.4    Cunningham, B.C.5    Lowman, H.B.6    De Vos, A.M.7
  • 80
    • 0032962265 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics, interspecies scaling, and tissue distribution of a humanized monoclonal antibody against vascular endothelial growth factor
    • Y.S. Lin, C. Nguyen, J.L. Mendoza, E. Escandon, D. Fei, Y.G. Meng, and N.B. Modi Preclinical pharmacokinetics, interspecies scaling, and tissue distribution of a humanized monoclonal antibody against vascular endothelial growth factor J. Pharmacol. Exp. Ther. 288 1999 371 378
    • (1999) J. Pharmacol. Exp. Ther. , vol.288 , pp. 371-378
    • Lin, Y.S.1    Nguyen, C.2    Mendoza, J.L.3    Escandon, E.4    Fei, D.5    Meng, Y.G.6    Modi, N.B.7
  • 81
    • 13444278498 scopus 로고    scopus 로고
    • Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies
    • H.P. Gerber, and N. Ferrara Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies Cancer Res. 65 2005 671 680
    • (2005) Cancer Res. , vol.65 , pp. 671-680
    • Gerber, H.P.1    Ferrara, N.2
  • 84
    • 0033027858 scopus 로고    scopus 로고
    • VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
    • H.P. Gerber, T.H. Vu, A.M. Ryan, J. Kowalski, Z. Werb, and N. Ferrara VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation Nat. Med. 5 1999 623 628
    • (1999) Nat. Med. , vol.5 , pp. 623-628
    • Gerber, H.P.1    Vu, T.H.2    Ryan, A.M.3    Kowalski, J.4    Werb, Z.5    Ferrara, N.6
  • 85
    • 0035253586 scopus 로고    scopus 로고
    • Phase Ib trial of intravenous recombinant humanized monoclonal antibody to vascular endothelial growth factor in combination with chemotherapy in patients with advanced cancer: Pharmacologic and long-term safety data
    • K. Margolin, M.S. Gordon, E. Holmgren, J. Gaudreault, W. Novotny, G. Fyfe, D. Adelman, S. Stalter, and J. Breed Phase Ib trial of intravenous recombinant humanized monoclonal antibody to vascular endothelial growth factor in combination with chemotherapy in patients with advanced cancer: pharmacologic and long-term safety data J. Clin. Oncol. 19 2001 851 856
    • (2001) J. Clin. Oncol. , vol.19 , pp. 851-856
    • Margolin, K.1    Gordon, M.S.2    Holmgren, E.3    Gaudreault, J.4    Novotny, W.5    Fyfe, G.6    Adelman, D.7    Stalter, S.8    Breed, J.9
  • 87
    • 0037208589 scopus 로고    scopus 로고
    • Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
    • F. Kabbinavar, H.I. Hurwitz, L. Fehrenbacher, N.J. Meropol, W.F. Novotny, G. Lieberman, S. Griffing, and E. Bergsland Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer J. Clin. Oncol. 21 2003 60 65
    • (2003) J. Clin. Oncol. , vol.21 , pp. 60-65
    • Kabbinavar, F.1    Hurwitz, H.I.2    Fehrenbacher, L.3    Meropol, N.J.4    Novotny, W.F.5    Lieberman, G.6    Griffing, S.7    Bergsland, E.8
  • 88
    • 16544379329 scopus 로고    scopus 로고
    • A randomized Phase II trial comparing rhumab VEGF (recombinant humanized monoclonal antibody to vascular endothelial cell growth factor) plus Carboplatin/Paclitaxel (CP) to CP alone in patients with stage IIIB/IV NSCLC
    • New Orleans, Louisiana, 2000.
    • R. DeVore, R.S. Herbst, C.J. Langer, K. Kelly, J. Gaudreault, E. Holmgren, W.F. Novotny, F. Kabbinavar, A randomized Phase II trial comparing rhumab VEGF (recombinant humanized monoclonal antibody to vascular endothelial cell growth factor) plus Carboplatin/Paclitaxel (CP) to CP alone in patients with stage IIIB/IV NSCLC, 36th ASCO Annual Meeting, New Orleans, Louisiana, 2000. (2000).
    • (2000) 36th ASCO Annual Meeting
    • Devore, R.1    Herbst, R.S.2    Langer, C.J.3    Kelly, K.4    Gaudreault, J.5    Holmgren, E.6    Novotny, W.F.7    Kabbinavar, F.8
  • 92
    • 1842569206 scopus 로고    scopus 로고
    • A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer
    • R.M. Goldberg, D.J. Sargent, R.F. Morton, C.S. Fuchs, R.K. Ramanathan, S.K. Williamson, B.P. Findlay, H.C. Pitot, and S.R. Alberts A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer J. Clin. Oncol. 22 2004 23 30
    • (2004) J. Clin. Oncol. , vol.22 , pp. 23-30
    • Goldberg, R.M.1    Sargent, D.J.2    Morton, R.F.3    Fuchs, C.S.4    Ramanathan, R.K.5    Williamson, S.K.6    Findlay, B.P.7    Pitot, H.C.8    Alberts, S.R.9
  • 93
    • 0002235290 scopus 로고    scopus 로고
    • Phase III trial of capecitabine (Xeloda) plus bevacizumab (Avastine) versus capecitabine alone in women with metastatic breast cancer (MBC) previously treated with an anthracycline and a taxane
    • K.D. Miller, H.S. Rugo, M.A. Cobleigh, P.K. Marcom, L.I. Chap, and F.A. Holmes Phase III trial of capecitabine (Xeloda) plus bevacizumab (Avastine) versus capecitabine alone in women with metastatic breast cancer (MBC) previously treated with an anthracycline and a taxane Breast Cancer Res. Treat. 76 2002 S37
    • (2002) Breast Cancer Res. Treat. , vol.76 , pp. 37
    • Miller, K.D.1    Rugo, H.S.2    Cobleigh, M.A.3    Marcom, P.K.4    Chap, L.I.5    Holmes, F.A.6
  • 94
    • 1442305186 scopus 로고    scopus 로고
    • Emerging roles of targeted small molecule protein-tyrosine kinase inhibitors in cancer therapy
    • J.K. Smith, N.M. Mamoon, and R.J. Duhe Emerging roles of targeted small molecule protein-tyrosine kinase inhibitors in cancer therapy Oncol. Res. 14 2004 175 225
    • (2004) Oncol. Res. , vol.14 , pp. 175-225
    • Smith, J.K.1    Mamoon, N.M.2    Duhe, R.J.3
  • 96
    • 0037280306 scopus 로고    scopus 로고
    • The role of VEGF in normal and neoplastic hematopoiesis
    • H.P. Gerber, and N. Ferrara The role of VEGF in normal and neoplastic hematopoiesis J. Mol. Med. 81 2003 20 31
    • (2003) J. Mol. Med. , vol.81 , pp. 20-31
    • Gerber, H.P.1    Ferrara, N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.