A reexamination of active and passive tumor targeting by using rod-shaped gold nanocrystals and covalently conjugated peptide ligands

ACS Nano

Volumn 4, Issue 10, 2010, Pages 5887-5896

  Huang, Xiaohua ^a,b   Peng, Xianghong ^c   Wang, Yiqing ^a   Wang, Yuxiang ^c   Shin, Dong M ^c   El Sayed, Mostafa A ^d   Nie, Shuming ^a  

^a EMORY UNIVERSITY   (United States)

^b University of Memphis   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

EGFR; gold nanorod; lung cancer; nanoparticle delivery; peptide; RGD; tumor targeting; uPAR

Indexed keywords

EGFR; GOLD NANOROD; LUNG CANCER; RGD; TUMOR TARGETING; UPAR;

ANIMALS; BIOLOGICAL ORGANS; CELL CULTURE; ENZYME ACTIVITY; ENZYME INHIBITION; LIGANDS; MASS SPECTROMETRY; MEDICAL NANOTECHNOLOGY; NANOCRYSTALS; NANOPARTICLES; NANORODS; ONCOLOGY; PEPTIDES; PLASMONS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; TUMORS;

GOLD;

ARGINYL-GLYCYL-ASPARTIC ACID; ARGINYLGLYCYLASPARTIC ACID; EPIDERMAL GROWTH FACTOR RECEPTOR; GOLD; LIGAND; MACROGOL DERIVATIVE; METAL NANOPARTICLE; OLIGOPEPTIDE; PEPTIDE; UROKINASE RECEPTOR;

ARTICLE; CHEMISTRY; HUMAN; LUNG TUMOR; MASS SPECTROMETRY; MATERIALS TESTING; METABOLISM; METHODOLOGY; NANOMEDICINE; NANOTECHNOLOGY; SURFACE PROPERTY;

GOLD; HUMANS; LIGANDS; LUNG NEOPLASMS; MASS SPECTROMETRY; MATERIALS TESTING; METAL NANOPARTICLES; NANOMEDICINE; NANOTECHNOLOGY; OLIGOPEPTIDES; PEPTIDES; POLYETHYLENE GLYCOLS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, UROKINASE PLASMINOGEN ACTIVATOR; SURFACE PROPERTIES;

EID: 78049351925     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn102055s     Document Type: Article

References (61)

1. Ferrari, M. Cancer Nanotechnology: Opportunities and Challenges Nat. Rev. Cancer 2005, 5, 161-171
2. Farokhzad, O. C; Langer, R. Nanomedicine: Developing Smarter Therapeutic and Diagnostic Modalities Adv. Drug Delivery Rev. 2006, 58, 1456-1459
3. Nie, S.; Xing, Y.; Kim, G. J.; Simons, J. M. Nanotechnology Applications in Cancer Annu. Rev. Biomed. Eng. 2007, 9, 257-288
4. Sanhai, W. R.; Sakamoto, J. H.; Canady, R.; Ferrari, M. Seven Challenges for Nanomedicine Nat. Nanotechnol. 2008, 3, 242-244
5. Heath, J. R; Davis, M. E. Nanotechnology and Cancer Annu. Rev. Med. 2008, 59, 251-265
6. Davis, M. E.; Chen, Z(G).; Shin, D. M. Nanoparticles Therapeutics: An Emerging New Treatment Modality for Cancer Nat. Rev. Drug Discovery 2008, 7, 771-782
7. Cho, K. J.; Wang, X.; Nie, S.; Chen, Z(G).; Shin, D. M. Therapeutic Nanoparticles for Drug Delivery in Cancer Clin. Cancer Res. 2008, 14, 1310-1316
8. Riehemann, K.; Schneider, S. W.; Luger, T. A; Godin, B.; Ferrari, M.; Fuchs, H. Nanomedicine-Challenge and Perspectives Angew. Chem., Int. Ed. 2009, 48, 872-897
9. Philips, M. A.; Gran, M. L.; Peppas, N. A. Targeted Nanodelivery of Drugs and Diagnostics Nano Today 2010, 5, 143-159
10. Nie, S. M. Understanding and Overcoming Major Barriers in Cancer Nanomedicine Nanomedicine 2010, 5, 523-528
11. Jain, R. K. Transport of Molecules, Particles, and Cells in Solid Tumors Annu. Rev. Biomed. Eng. 1999, 1, 241-63
12. Maeda, H.; Wu, J.; Sawa, T.; Matsumura, Y.; Hori, K. Tumor Vascular Permeability and the EPR Effect in Macromolecular Therapeutics: A Review J. Controlled Release 2000, 65, 271-84
13. Matsumura, Y.; Maeda, H. A New Concept for Macromolecular Therapeutics in Cancer-Chemotherapy-Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs Cancer Res. 1986, 46, 6387-6392
14. Pirollo, K. F.; Chang, E. H. Does a Targeting Ligand Influence Nanoparticle Tumor Localization or Uptake Trends Biotechnol. 2008, 26, 552-555
15. Kirpotin, D. B.; Drummond, D. C.; Shao, Y.; Shalaby, M. R.; Hong, K.; Nielsen, U. B.; Marks, J. D.; Benz, C. C.; Park, J. W. Antibody Targeting of Long-Circulating Lipidic Nanoparticles Does Not Increase Tumor Localization But Does Increase Internalization in Animal Models Cancer Res. 2006, 66, 6732-6740
16. Bartlett, D. W.; Su, H.; Hildebrand, I. J.; Weber, W. A.; Davis, M. E. Impact of Tumor-Specific Targeting on the Biodistribution and Efficacy of Sirna Nanoparticles Measured by Multimodality in Vivo Imaging Proc. Natl. Acad. Sci. U. S. A. 2007, 104, 15549-15554
17. Choi, C. H. J; Alabi, C. A.; Webster, P.; Davis, M. E. Mechanism of Active Targeting in Solid Tumors with Transferrin-Containing Gold Nanoparticles Proc. Natl. Acad. Sci. U. S. A 2010, 107, 1235-1240
18. Schmidt, M. M.; Wittrup, K. D. A Modeling Analysis of the Effects of Molecular Size and Binding Affinity on Tumor Targeting Mol. Cancer Ther. 2009, 8, 2861-2871
19. Garanger, E.; Boturyn, D.; Dumy, P. Tumor Targeting with RGD Peptide Ligands-Design of New Molecular Conjugates for Imaging and Therapy of Cancers Anticancer Agents Med. Chem. 2007, 7, 552-558
20. de Bruin, K.; Ruthardt, N.; Von Gersdorff, K.; Bausinger, R.; Wagner, E.; Ogris, M.; Bräuchls, C. Cellular Dynamics of EGF Receptor-Targeted Synthetic Viruses Mol. Ther. 2007, 15, 1297-1305
21. Hilgenbrink, A. R.; Low, P. S. Folate Receptor-Mediated Drug Targeting: From Therapeutics to Diagnostics J. Pharm. Sci. 2005, 94, 2135-2146
22. Xu, L.; Pirollo, K. F.; Tang, W. H.; Rait, A.; Chang, E. H. Transferrin-Liposome-Mediated Systemic P53 Gene Therapy in Combination with Radiation Results in Regression of Human Head and Neck Cancer Xenografts Hum. Gene Ther. 1999, 10, 2941-2952
23. Daniels, T. R.; Delgado, T.; Rodriguez, J. A.; Helguera, G.; Penichet, M. L. The Transferrin Receptor Part I: Biology and Targeting with Cytotoxic Antibodies for the Treatment of Cancer Clin. Immunol. 2006, 121, 144-158
24. Dass, C. R.; Choong, P. F. Selective Gene Delivery for Cancer Therapy Using Cationic Liposomes: In Vivo Proof of Applicability J. Controlled Release 2006, 113, 155-163
25. Koyama, Y.; Hama, Y.; Urano, Y.; Nguyen, D. M.; Choyke, P. L.; Kobayashi, H. Spectral Fluorescence Molecular Imaging of Lung Metastases Targeting HER2/Neu Clin. Cancer Res. 2007, 13, 2936-2945
26. Fidaroval, E. F.; El-Emir, E.; Boxer, G. M.; Qureshi, U.; Dearling, J. L. L.; Robson, M. P.; Begent, R. H. J.; Trott, K. R.; Pedlley, R. B. Microdistribution of Targeted, Fluorescently Labeled Anti Carcinoembryonic Antigen Antibody in Metastatic Colorectal Cancer: Implications for Radioimmunotherapy Clin. Cancer Res. 2008, 14, 2639-2646
27. Gabizon, A.; Horowitz, A. T.; Goren, D.; Tzemach, D.; Shmeeda, H.; Zalipsky, S. In Vivo Fate of Folate-Targeted Polyethylene-Glycol Liposomes in Tumor-Bearing Mice Clin. Cancer Res. 2003, 9, 6551-6559
28. Montet, X.; Funovics, M.; Montet-Abou, K.; Weissleder, R.; Josephson, L. Multivalent Effects of RGD Peptides Obtained by Nanoparticle Display J. Med. Chem. 2006, 49, 6087-6093
29. McNeeley, K. M.; Annapragada, A.; Bellamkonda, R. V. Decreased Circulation Time Offsets Increased Efficacy of Pegylated Nanocarriers Targeting Folate Receptors of Glioma Nanotechnology 2007, 18, 385101
30. Geng, Y.; Dalhaimer, P.; Cai, S.; Tsai, R.; Tewari, M.; Minko, T.; Discher, D. E. Shape Effects of Filaments Versus Spherical Particles in Flow and Drug Delivery Nat. Nanotechnol. 2007, 2, 249-255
31. Park, J. H.; von Maltzahn, G.; Zhang, L; Derfus, A. M.; Simberg, D.; Harris, T. J.; Ruoslahti, E.; Bhatia, S. N.; Sailor, M. J. Systematic Surface Engineering of Magnetic Nanoworms for in Vivo Tumor Targeting Small 2009, 5, 694-700
32. Rosen, A. L.; Hieftje, G. M. Inductively Coupled Plasma Mass Spectrometry and Electrospray Mass Spectrometry for Speciation Analysis: Applications and Instrumentation Spectrochim. Acta, Part B 2004, 59, 135-146
33. Huang, X.; El-Sayed, I. H.; Qian, W.; El-Sayed, M. A. Cancer Cell Imaging and Photothermal Therapy in the Near-Infrared Region by Using Gold Nanorods J. Am. Chem. Soc. 2006, 128, 2115-2120
34. Ding, H.; Yong, K. T.; Roy, I.; Pudavar, H. E.; Law, W. C.; Bergey, E. J.; Prasad, P. N. Gold Nanorods Coated with Multilayer Polyelectrolyte as Contrast Agents for Multimodal Imaging J. Phys. Chem. C 2007, 111, 12552-12557
35. Oldenburg, A. L.; Hansen, M. N.; Ralston, T. S.; Wei, A.; Boppart, S. A. Imaging Gold Nanorods in Excised Human Breast Carcinoma by Spectroscopic Optical Coherence Tomography J. Mater. Chem. 2009, 19, 6407-6411
36. Agarwal, A.; Huang, S. W.; ODonnell, M.; Day, K. C.; Day, M.; Kotov, N.; Ashkenazi, S. Targeted Gold Nanorod Contrast Agent for Prostate Cancer Detection by Photoacoustic Imaging J. Appl. Phys. 2007, 102 064701
37. Li, P. C.; Wang, C. R. C.; Shieh, D. B.; Wei, C. W.; Liao, C. K.; Poe, C.; Jhan, S.; Ding, A. A.; Wu, Y. N. In Vivo Photoacoustic Molecular Imaging with Simultaneous Multiple Selective Targeting Using Antibody-Conjugated Gold Nanorods Opt. Exp. 2008, 16, 18605-18615
38. Wang, H.; Huff, T. B.; Zweifel, D. A.; He, W.; Low, P. S.; Wei, A.; Cheng, J. X. In Vitro and In Vivo Two-Photon Luminescence Imaging of Single Gold Nanorods Proc. Natl. Acad. Sci. U. S. A. 2005, 102, 15752-15756
39. Durr, N. J.; Larson, T.; Smith, D. K.; Korgel, B. A.; Sokolov, K; Ben-Yakar, A. Two-Photon Luminescence Imaging of Cancer Cells Using Molecularly Targeted Gold Nanorods Nano Lett. 2007, 7, 941-945
40. Yu, C.; Irudayaraj, J. Quantitative Evaluation of Sensitivity and Selectivity of Multiplex Nanospr Biosensor Arrays Biophys. J. 2007, 93, 3684-3692
41. Wang, C.; Chen, Y.; Wang, T.; Ma, Z.; Su, Z. Biorecognition-Driven Self-Assembly of Gold Nanorods: A Rapid and Sensitive Approach toward Antibody Sensing Chem. Mater. 2007, 19, 5809-5811
42. Mayer, K. M.; Lee, S.; Liao, H.; Rostro, B. C.; Fuentes, A.; Scully, P. T.; Nehl, C. L.; Hafner, J. H. A Label-Free Immunoassay Based upon Localized Surface Plasmon Resonance of Gold Nanorods ACS Nano 2008, 2, 687-692
43. Huang, X.; El-Sayed, I. H.; Qian, W.; El-Sayed, M. A. Cancer Cells Assemble and Align Gold Nanorods Conjugated to Antibodies to Produce Highly Enhanced, Sharp and Polarized Surface Raman Spectra: A Potential Cancer Diagnostic Marker Nano Lett. 2007, 7, 1591-1597
44. von Maltzahn, G.; Park, J. H.; Agrawal, A.; Bandaru, N. K.; Das, S. K.; Sailor, M. J.; Bhatia, S. N. Computationally Guided Photothermal Tumor Therapy Using Long-Circulating Gold Nanorod Antennas Cancer Res. 2009, 69, 3892-3900
45. Takahashi, H.; Niidome, T.; Nariai, A.; Niidome, Y.; Yamada, S. Gold Nanorod-Sensitized Cell Death: Microscopic Observation of Single Living Cells Irradiated by Pulsed Near-Infrared Laser Light in the Presence of Gold Nanorods Chem. Lett. 2006, 35, 500-501
46. Tong, L.; Zhao, Y.; Huff, T. B.; Hansen, M. N.; Wei, A.; Cheng, J. X. Gold Nanorods Mediate Tumor Cell Death by Compromising Membrane Integrity Adv. Mater. 2007, 19, 3136-3141
47. Dickerson, E. B.; Dreaden, E. C.; Huang, X.; El-Sayed, I. H.; Chu, H.; Pushpanketh, S.; McDonald, J. F.; El-Sayed, M. A. Gold Nanorod Assisted Near-Infrared Plasmonic Photothermal Therapy (PPTT) of Squamous Cell Carcinoma in Mice Cancer Lett. 2008, 269, 57-66
48. Li, J. L.; Day, D.; Gu, M. Ultra-Low Energy Threshold for Cancer Photothermal Therapy Using Transferrin-Conjugated Gold Nanorods Adv. Mater. 2008, 20, 3866-3871
49. Niidome, T.; Akiyama, Y.; Yamagata, M.; Kawano, T.; Mori, T.; Niidome, Y.; Katayama, Y. Poly(ethylene glycol)-Modified Gold Nanorods as a Photothermal Nanodevice for Hyperthermia J. Biomater. Sci. 2009, 20, 1203-1215
50. 3 Expression Patterns in Lung Cancers with RGD-USPIO Using a Clinical 3.0T MR Scanner Int. J. Nanomed. 2009, 4, 241-149
51. Zhang, C.; Lv, F.; Zhou, L.; Li, X.; Wu, X. X.; Hoffman, R. M. Effect of Verapamil on the Expression of EGFR and NM23 in A549 Human Lung Cancer Cells Anticancer Res. 2009, 29, 27-32
52. Kim, I. Y.; Kang, Y. S.; Lee, D. S.; Park, H. J.; Choi, E. K.; Oh, Y. K.; Son, H. J.; Kim, J. S. Antitumor Activity of EGFR Targeted pH-Sensitive Immunoliposomes Encapsulating Gemcitabine in A549 Xenograft Nude Mice J. Controlled Release 2009, 140, 55-60
53. Yamamoto, M.; Ikeda, K.; Ohshima, K.; Tsugu, H.; Kimura, H.; Tomonaga, M. Increased Expression of Low Density Lipoprotein Receptor-related Protein/a2-Macroglobulin Receptor in Human Malignant Astrocytomas Cancer Res. 1997, 57, 2799-2805
54. Hattori, N.; Sisson, T. H.; Xu, Y.; Desai, T. J.; Simon, R. H. Participation of Urokinase-Type Plasminogen Activator Receptor in the Clearance of Fibrin from the Lung Am. J. Physiol. Lung Cell Mol. Physiol. 1999, 277, 573-579
55. Hood, J. D.; Cheresh, D. A. Role of Integrin in Cell Invasion and Migration Nat. Rev. Cancer 2002, 2, 91-100
56. Jin, H.; Varner, J. Integrins: Roles in Cancer Development and as Treatment Targets Br. J. Cancer 2004, 90, 561-565
57. Blasi, F.; Carmeliet, P. uPAR: a Versatile Signaling Orchestrator Nat. Rev. Mol. Biol. 2002, 3, 933-943
58. Nikoobakht, B.; El-Sayed, M. A. Preparation and Growth Mechanism of Gold Nanorods (NRs) Using Seed-Mediated Growth Method Chem. Mater. 2003, 15, 1957-1961
59. Josephson, L.; Tung, C. H.; Moore, A.; Weissleder, R. High-Efficiency Intracellular Magnetic Labeling with Novel Superparamagnetic-Tat Peptide Conjugates Bioconjugate Chem. 1999, 10, 186-191
60. Gao, X.; Cui, Y.; Levenson, R. M.; Chung, L. W. K.; Nie, S. In Vivo Cancer Targeting and Imaging with Semiconductor Quantum Dots Nat. Biotechnol. 2004, 22, 969-976
61. Gu, F.; Zhang, L.; Teply, B. A.; Mann, N.; Wang, A.; Radovic-Moreno, A. F.; Langer, R.; Farokhzad, O. C. Precise Engineering of Targeted Nanoparticles by Using Self-Assembled Biointegrated Block Copolymers Proc. Natl. Acad. Sci. U. S. A. 2008, 105, 2586-2591