Enhanced endosomal escape of siRNA-incorporating hybrid nanoparticles from calcium phosphate and PEG-block charge-conversional polymer for efficient gene knockdown with negligible cytotoxicity

Biomaterials

Volumn 32, Issue 11, 2011, Pages 3106-3114

  Pittella, Frederico ^a   Zhang, Mingzhen ^a,c   Lee, Yan ^a,d   Kim, Hyun J ^a   Tockary, Theofilus ^a   Osada, Kensuke ^a   Ishii, Takehiko ^a   Miyata, Kanjiro ^b   Nishiyama, Nobuhiro ^b   Kataoka, Kazunori ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c WENZHOU MEDICAL UNIVERSITY   (China)

^d Seoul National University   (South Korea)

Author keywords

Calcium phosphate nanoparticles; Charge conversional polymer (CCP); Endosomal escape; Poly(ethylene glycol) (PEG); SiRNA; Vascular endothelial growth factor (VEGF)

Indexed keywords

CALCIUM PHOSPHATE NANOPARTICLES; CHARGE-CONVERSIONAL POLYMER (CCP); ENDOSOMAL ESCAPE; POLY(ETHYLENE GLYCOL) (PEG); SIRNA; VASCULAR ENDOTHELIAL GROWTH FACTOR;

BLOCK COPOLYMERS; CALCIUM; CYTOLOGY; DRUG DELIVERY; ENDOTHELIAL CELLS; ETHYLENE; ETHYLENE GLYCOL; GENE THERAPY; NANOPARTICLES; NUCLEIC ACIDS; PEPTIDES; PHOSPHATES; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; POLYMERS; RNA; SELF ASSEMBLY;

CALCIUM PHOSPHATE;

CALCIUM PHOSPHATE; CHARGE CONVERSIONAL POLYMER; MACROGOL; MESSENGER RNA; NANOCARRIER; NANOPARTICLE; POLYANION; POLYCATION; POLYMER; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASCULOTROPIN;

ARTICLE; CANCER CELL; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DEGRADATION; ENDOSOME; GENE SILENCING; HYBRID; MEMBRANE STABILIZATION; PRIORITY JOURNAL;

CALCIUM PHOSPHATES; CELL LINE, TUMOR; ENDOSOMES; GENE KNOCKDOWN TECHNIQUES; HUMANS; MICROSCOPY, CONFOCAL; MOLECULAR STRUCTURE; NANOPARTICLES; POLYETHYLENE GLYCOLS; POLYMERS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING;

EID: 79951578276     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.12.057     Document Type: Article

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