Liver X receptors in lipid metabolism: Opportunities for drug discovery

Nature Reviews Drug Discovery

Volumn 13, Issue 6, 2014, Pages 433-444

  Hong, Cynthia ^a   Tontonoz, Peter ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [3 [[2 CHLORO 3 (TRIFLUOROMETHYL)BENZYL](2 DIPHENYLETHYL)AMINO]PROPOXY]PHENYLACETIC ACID; ABC TRANSPORTER; AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; BEXAROTENE; BMS 779788; BMS 852927; CS 8080; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYODEOXYCHOLIC ACID; INDUCIBLE DEGRADER OF THE LOW DENSITY LIPOPROTEIN RECEPTOR; LIVER X RECEPTOR; LIVER X RECEPTOR AGONIST; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; LOW DENSITY LIPOPROTEIN RECEPTOR; LXR 623; N (2,2,2 TRIFLUOROETHYL) N [4 (2,2,2 TRIFLUORO 1 HYDROXY 1 TRIFLUOROMETHYLETHYL)PHENYL]BENZENESULFONAMIDE; RETINOID X RECEPTOR; STEROL REGULATORY ELEMENT BINDING PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; XL 041; XL 652;

ALZHEIMER DISEASE; ANTIINFLAMMATORY ACTIVITY; AORTA ATHEROSCLEROSIS; ATHEROGENESIS; ATHEROSCLEROSIS; BRAIN METABOLISM; CARDIOVASCULAR DISEASE; CHOLESTEROL TRANSPORT; CUTANEOUS T CELL LYMPHOMA; DRUG STRUCTURE; FATTY ACID METABOLISM; GLUCOSE METABOLISM; HUMAN; HYPERCHOLESTEROLEMIA; LIPID METABOLISM; LIPOGENESIS; MACROPHAGE; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; REVIEW; STEROL EXCRETION;

ALZHEIMER DISEASE; ANIMALS; ATHEROSCLEROSIS; BRAIN; CLINICAL TRIALS AS TOPIC; DRUG DESIGN; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; DRUGS, INVESTIGATIONAL; HUMANS; HYPOLIPIDEMIC AGENTS; INTESTINES; LIPID METABOLISM; LIVER; MOLECULAR TARGETED THERAPY; NERVE TISSUE PROTEINS; NEURONS; NOOTROPIC AGENTS; ORPHAN NUCLEAR RECEPTORS; PROTEIN ISOFORMS; SIGNAL TRANSDUCTION;

EID: 84901937811     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd4280     Document Type: Review

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