Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I

Journal of Clinical Investigation

Volumn 115, Issue 5, 2005, Pages 1333-1342

  Timmins, Jenelle M ^a   Lee, Ji Young ^a   Boudyguina, Elena ^a   Kluckman, Kimberly D ^b   Brunham, Liam R ^c   Mulya, Anny ^a   Gebre, Abraham K ^a   Coutinho, Jonathan M ^c   Colvin, Perry L ^d   Smith, Thomas L ^a   Hayden, Michael R ^c   Maeda, Nobuyo ^b   Parks, John S ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A1; APOLIPOPROTEIN A1; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; PHOSPHOLIPID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOGENESIS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; FEMALE; GENE DELETION; GENE MUTATION; GENE TARGETING; GENOTYPE; HYPOALPHALIPOPROTEINEMIA; HYPOLIPOPROTEINEMIA; IN VIVO STUDY; KIDNEY; LIPID BLOOD LEVEL; LIPOLYSIS; LIPOPROTEIN BLOOD LEVEL; LIVER; LIVER CELL; LIVER FUNCTION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE BINDING SITE; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; TISSUE SPECIFICITY;

ANIMALS; APOLIPOPROTEIN A-I; ATP-BINDING CASSETTE TRANSPORTERS; GENE TARGETING; GENOTYPE; HEPATOCYTES; HUMANS; KIDNEY; LIPOPROTEINS, HDL; MACROPHAGES, PERITONEAL; MICE; MICE, KNOCKOUT; TANGIER DISEASE;

EID: 20944435724     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200523915     Document Type: Article

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