NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols

Journal of Biological Chemistry

Volumn 278, Issue 28, 2003, Pages 25517-25525

  Frolov, Andrey ^a   Zielinski, Sarah E ^a   Crowley, Jan R ^a   Dudley Rucker, Nicole ^a   Schaffer, Jean E ^a   Ory, Daniel S ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; DISEASE CONTROL; ESTERIFICATION; GENES; MUTAGENESIS;

FIBROBLASTS;

CHOLESTEROL;

25 HYDROXYCHOLESTEROL; 26 HYDROXYCHOLESTEROL; LIVER X RECEPTOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OXYSTEROL; RECEPTOR; STEROL REGULATORY ELEMENT BINDING PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL LEVEL; CHOLESTEROL ESTERIFICATION; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; FIBROBLAST; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE MUTATION; GENE NPC1; GENE NPC2; HOMEOSTASIS; HUMAN; HUMAN CELL; NIEMANN PICK DISEASE; PRIORITY JOURNAL;

CARRIER PROTEINS; CELLS, CULTURED; CHOLESTEROL; CHOLESTEROL, LDL; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; FIBROBLASTS; FILIPIN; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GENES, REPORTER; GLYCOPROTEINS; HUMANS; HYDROXYCHOLESTEROLS; LIPOPROTEINS; LIPOPROTEINS, LDL; LUCIFERASES; MEMBRANE GLYCOPROTEINS; MICROSCOPY, FLUORESCENCE; MUTATION; NIEMANN-PICK DISEASES; OXYGEN; PHENOTYPE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SKIN; STEROLS; TRANSFECTION;

EID: 0037815282     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M302588200     Document Type: Article

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