Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Aβ levels

Journal of Biological Chemistry

Volumn 277, Issue 50, 2002, Pages 48508-48513

  Fukumoto, Hiroaki ^a   Deng, Amy ^a   Irizarry, Michael C ^a   Fitzgerald, Michael L ^a   Rebeck, G William ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Alzheimer Research Unit   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; BRAIN; CELLS; CHOLESTEROL; DISEASES; FLUORESCENCE; HORMONES; METABOLISM; NEUROLOGY; TISSUE;

DISEASE RISK;

BIOCHEMISTRY;

22 HYDROXYCHOLESTEROL; ABC TRANSPORTER; ABCA1 TRANSPROTER; BETA AMYLASE; CELL NUCLEUS RECEPTOR; CHOLESTEROL DERIVATIVE; GREEN FLUORESCENT PROTEIN; LIVER X RECEPTOR; OXYSTEROL; RETINOIC ACID; RETINOID X RECEPTOR; TO 901317; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN METABOLISM; BRAIN TISSUE; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; GLIA CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN SITU HYBRIDIZATION; MOUSE; NERVE CELL; NEUROBLASTOMA CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN LOCALIZATION; RAT; SIGNAL TRANSDUCTION;

AMYLOID BETA-PROTEIN; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BASE SEQUENCE; BLOTTING, WESTERN; CENTRAL NERVOUS SYSTEM; CHOLESTEROL; DNA PRIMERS; DNA-BINDING PROTEINS; IN SITU HYBRIDIZATION; MICE; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SUBCELLULAR FRACTIONS; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0037073670     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209085200     Document Type: Article

References (60)

1. Oram, J. F., and Lawn, R. M. (2001) J. Lipid Res. 42, 1173-1179
2. Walter, M., Gerdes, U., Seedorf, U., and Assmann, G (1994) Biochem. Biophys. Res. Commun. 205, 850-856
3. Rogler, G., Trumbach, B., Klima, B., Lackner, K. J., and Schmitz, G. (1995) Arterioscler. Thromb. Vasc. Biol. 15, 683-690
4. Francis, G. A., Knopp, R. H., and Oram, J. F. (1995) J. Clin. Invest. 96, 78-87
5. Orso, E., Broccardo, C., Kaminski, W. E., Bottcher, A., Liebisch, G., Drobnik, W., Gotz, A., Chambenoit, O., Diederich, W., Langmann, T., Spruss, T., Luciani, M. F., Rothe, G., Lackner, K. J., Chimini, G., and Schmitz, G. (2000) Nat. Genet. 24, 192-196
6. Repa, J. J., Turley, S. D., Lobaccaro, J. A., Medina, J., Li, L., Lustig, K., Shan, B., Heyman, R. A., Dietschy, J. M., and Mangelsdorf, D. J. (2000) Science 289, 1524-1529
7. Coster, P., Luo, Y., Wing, N., and Tall, A. R. (2000) J. Biol. Chem. 275, 28240-28245
8. Venkateswaran, A., Lafitte, B. A., Joseph, S. B., Mak, P. A., Wilpitz, D. C., Edwards, P. A., and Tontonoz, P. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 12097-12102
9. Oliver, W. R., Jr., Shenk, J. L., Snaith, M. R., Russell C. S., Plunket, K. D., Bodkin, N. L., Lewis, M. C., Winegar, D. A., Sznaidman, M. L., Lambert, M. H., Xu, H. E., Sternbach, D. D., Kliewer, S. A., Hansen, B. C., and Willson, T. M. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 5306-5311
10. Langmann, T., Klucken, J., Reil, M., Liebisch, G., Luciani, M. F., Chimini, G., Kaminski, W. E., and Schmitz, G. (1999) Biochem. Biophys. Res. Commun. 257, 29-33
11. Mahley, R. W. (1988) Science 240, 622-630
12. Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., and Roses, A. D. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 1977-1981
13. Rebeck, G. W., Retter, J. S., Strickland, D. K., and Hyman, B. T. (1993) Neuron 11, 575-580
14. Simons, M., Keller, P., De Strooper, B., Betreuther, K., Dotti, C. G., and Simons, K. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 6460-6464
15. Fassbender, K., Simons, M., Bergmann, C., Stroick, M., Lutjohann, D., Keller, P., Runz, H., Kuhl, S., Bertsch, T., van Bergmann, K., Hennerici, M., Beyreuther, K., and Hartmann, T. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 5856-5861
16. Puglielli, L., Konopka, G., Pack-Chung, E., Ingano, L. A. M., Berezovska, O., Hyman, B. T., Chang, T. Y., Tanzi, R. E., and Kovacs, D. M. (2001) Nat. Cell Biol. 3, 905-912
17. Refolo, L. M., Pappolla, M. A., Malester, B., LaFrancois, J., Thomas-Bryant, T., Wang, R., Tint, G. S., Sambamurti, K., and Duff, K. E. (2000) Neurobiol. Dis. 7, 321-331
18. Refolo, L. M., Pappolla, M. A., LaFrancois, J., Malester, B., Schmidt, S. D., Thomas-Bryant, T., Tint, G. S., Wang, R., Mercken, M., Petanceska, S. S., and Duff, K. E. (2001) Neurobiol. Dis. 8, 890-899
19. Notkola, I. L., Sulkava, R., Pekkanen, J., Erkinjuntti, T., Ehnholm, C., Kivinen, P., Tuomilehto, J., and Nissinen, A. (1998) Neuroepidemiology 17, 14-20
20. Kivipelto, M., Helkala, E. L., Laakso, M. P., Hanninen, T., Hallikainen, M., Alhainen, K., Soininen, H., Tuomilehto, J., and Nissinen, A. (2001) Br. Med. J. 322, 1447-1451
21. Jick, H., Zornberg, G. L., Jick, S. S., Seshadri, S., and Drachman, D. A. (2000) Lancet 356, 1627-1631
22. Wolozin, B., Kellman, W., Ruosseau, P., Celesia, G. G., and Siegel, G. (2000) Arch. Neurol. 57, 1439-1443
23. Rockwood, K., Kirkland, S., Hogan, D. B., MacKnight, C., Merry, H., Verreault, R., Wolfson, C., and McDowell, I. (2002) Arch. Neurol. 59, 223-227
24. Fitzgerald, M. L., Mendez, A. J., Moore, K. J., Andersson, L. P., Panjeton, H. A., and Freeman, M. W. (2001) J. Biol. Chem. 276, 15137-15145
25. Page, K., Hollister, R., Tanzi, R. E., and Hyman, B. T. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 14020-14024
26. Irizarry, M. C., McNamara, M., Fedorchak, K., Hsaio, K., and Hyman, B. T. (1997) J. Neuropathol. Exp. Neurol. 56, 965-973
27. Qiu, Z., Strickland, D. K., Hyman, B. T., and Rebeck, G. W. (1999) J. Neurochem. 73, 1393-1398
28. Fukumoto, H., Tomita, T., Matsunaga, H. Ishibashi, Y., Saido, T. C., and Iwatsubo, T. (1999) NeuroReport 10, 2965-2969
29. Neufeld, E. B., Remaley, A. T., Demosky, S. J., Stonik, J. A., Cooney, A. M., Comly, M., Dwyer, N. K., Zhang, M., Blanchette-Mackie, J., Santamarina-Fojo, S., and Brewer, H. B., Jr. (2001) J. Biol. Chem. 276, 27584-27590
30. Hardy, J., and Selkoe, D. J. (2002) Science 297, 353-356
31. Wellington, C. L., Walker, E. K., Suarez, A., Kwok, A., Bissada, N., Singaraja, R., Yang, Y. Z., Zhang, L. H., James, E., Wilson, J. E., Francone, O., McManus, B. M., and Hayden, M. R. (2002) Lab. Invest. 82, 273-283
32. Luciani, M. F., Denizot, F., Savary, S., Mattei, M. G., and Chimni, G. (1994) Genomics 21, 150-159
33. Lawn, R. M., Wade, D. P., Couse, T. L., and Wilcox, J. N. (2001) Arterioscler. Thromb. Vasc. Biol. 21, 378-385
34. Page, K., Hollister, R. D., and Hyman, B. T. (1998) Neuroscience 85, 1161-1171
35. Whitney, K. D., Watson, M. A., Collins, J. L., Benson, W. G., Stone, T. M., Numerick, M. J., Tippin, T. K., Wilson, J. G., Winegar, D. A., and Kliewer, S. A. (2002) Mol. Endocrinol. 16, 1378-1385
36. Lund, E. G., Guileyardo, J. M., Russell, D. W. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 7238-7243
37. Lehman, J. M., Kliewer, S. A., Moore, L. B., Smith-Oliver, T. A., Oliver, B. B., Su, J.-L., Sundseth, S. S., Winegar, D. A., Blanchard, D. E., Spencer, T. A., and Willson, T. M. (1997) J. Biol. Chem. 272, 3137-3140
38. Janowski, B. A., Grogan, M. J., Jones, S. A., Wisely, G. B., Kliewer, S. A., Corey, E. J., and Mangelsdorf, D. J. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 266-271
39. Wang, L., Schuster, G. U., Hultenby, K., Zhang, Q., Andersson, S., and Gustafsson, J.-A. (2002) Proc. Natl. Acad. Sci, U. S. A. 99, 13878-13883
40. Bjorkhem, I., and Diczfalusy, U. (2002) Arterioscler. Thromb. Vasc. Biol. 22, 734-742
41. Pitas, R. E., Boyles, J. K., Lee, S. H., Hui, D., and Weisgraber, K. H. (1987) J. Biol. Chem. 262, 14352-14360
42. Borghini, I., Barja, F., Pometta, D., and James, R. W. (1995) Biochim. Biophys. Acta 1255, 192-200
43. Koch, S., Donarski, N., Goetze, K., Kreckel, M., Stuerenburg, H.-J., Buhmann, C., and Beisiegel, U. (2001) J. Lipid Res. 42, 1143-1151
44. Pitas, R. E., Boyles, J. K., Lee, S. H., Foss, D., and Mahley, R. W. (1987) Biochim. Biophys. Acta 917, 148-161
45. LaDu, M. J., Gilligan, S. M., Lukens, J. R., Cabana, V. G. Reardon, C. A., Van Eldik, L. J., and Holtzman, D. M. (1998) J. Neurochem. 70, 2070-2081
46. Wang, N., Silver, D. L., Costet, P., and Tall, A. R. (2000) J. Biol. Chem. 275, 33053-33058
47. Remaley, A. T., Stonik, J. A., Demosky, S. J., Neufeld, E. B. Bocharov, A. V. Vishnyakova, T. G. Eggerman, T. L., Patterson, A. P., Duverger, N. J., Santamarina-Fojo, S., and Brewer, H. B., Jr. (2001) Biochem. Biophys. Res. Commun. 280, 818-823
48. Rebeck, G. W., Alonzo, N. C., Berezovska, O., Harr, S. D. Knowles, R. B., Growdon, J. H., Hyman, B. T., and Mendez, A. J. (1998) Exp. Neurol. 149, 175-182
49. Michikawa, M., Fan, Q.-W., Isobe, I., and Yanagisawa, K. (2000) J. Neurochem. 74, 1008-1016
50. Mason, R. P., Jacob, R. F., Walter, M. F., Mason, P. A., Avdulov, N. A., Chochina, S. V., Igbavboa, U., and Wood, W. G. (1999) J. Biol. Chem. 274, 18801-18807
51. Koudinov, A., Matsubara, E., Frangione, B., and Ghiso, J. (1994) Biochem. Biophys. Res. Commun. 205, 1164-1171
52. Roberts, G. W., Gentleman, S. M., Lynch, A., Murray, L., Landon, M., and Graham, D. I. (1994) J. Neurol. Neurosurg. Psychiatry 57, 419-425
53. Uryu, K., Laure, H., McIntosh, T., Pratico, P., Martinez, D., Leight, S., Lee, V. M.-Y., and Trojanowski, J. Q. (2002) J. Neurosci. 22, 446-454
54. Guo, Z., Cupples, L. A., Kurz, A., Auerbach, S. H., Volicer, L., Chui, H., Green, R. C., Sadovnick, A. D., Duara, R., DeCarli, C., Johnson, K., Go, R. C., Growdon, J. H., Haines, J. L. Kukull, W. A., and Farrer, L. A. (2000) Neurology 54, 1316-1323
55. Nicoll, J. A. R., Roberts, G. W., and Graham, D. I. (1995) Nat. Med. 1, 135-137
56. Irizarry, M. C., Locascio, J. J., and Hyman, B. T. (2001) Am. J. Pathol. 158, 173-177
57. Schoenknecht, P., Lutjohann, D., Pantel, J., Bardenheuer, H., Hartmann, T., von Bergmann, K., Beyreuther, K., and Schroeder, J. (2002) Neurosci. Lett. 324, 83-85
58. Papassotiropoulos, A., Lutjohann, D., Bagli, M., Locatelli, S., Jessen, F., Buschfort, R., Ptok, U., Bjorkhem, I., von Bergmann, K., and Heun, R. (2002) J. Psych. Res. 36, 27-32
59. Lutjohann, D., Breuer, O., Ahlborg, G. Nennesmo, I., Siden, A., Diczfalusy, U., and Bjorkhem, I. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 9799-9804
60. Locatelli, S., Lutjohann, D., Schmidt, H. H. J., Otto, C., Beisiegel, U., and von Bergrmann, K. (2002) Arch. Neurol. 59, 213-216