Characterization of ASC-2 as an antiatherogenic transcriptional coactivator of liver X receptors in macrophages

Molecular Endocrinology

Volumn 23, Issue 7, 2009, Pages 966-974

  Geun, Hyang Kim ^a,c   Park, Keunhee ^b   Yeom, Seon Yong ^a   Kyung, Jin Lee ^a   Kim, Gukhan ^a   Ko, Jesang ^c   Rhee, Dong Kwon ^d   Young, Hoon Kim ^a   Hye, Kyung Lee ^a   Hae, Won Kim ^a   Goo, Taeg Oh ^e   Lee, Ki Up ^a   Lee, Jae W ^f   Kim, Seung Whan ^a  

^a University of Ulsan College of Medicine   (South Korea)

^b Pohang University of Science and Technology (POSTECH)   (South Korea)

^c Korea University   (South Korea)

^d Sungkyunkwan University   (South Korea)

^e Ewha Womans University   (South Korea)

^f BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A1; ABC TRANSPORTER G1; ACTIVATING SIGNAL COINTEGRATOR-2; APOLIPOPROTEIN E; CARRIER PROTEIN; CHOLESTEROL; LIVER X RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ATHEROGENESIS; BONE MARROW TRANSPLANTATION; CARBOXY TERMINAL SEQUENCE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; ATP-BINDING CASSETTE TRANSPORTERS; CELLS, CULTURED; DNA-BINDING PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPOPROTEINS; MACROPHAGES; MALE; MICE; MICE, KNOCKOUT; MUTANT PROTEINS; PROTEIN BINDING; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANS-ACTIVATORS; TRANSCRIPTIONAL ACTIVATION;

MUS; MUS MUSCULUS;

EID: 67649625405     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2008-0308     Document Type: Article

References (46)

1. Ross R 1999 Atherosclerosis: an inflammatory disease. N Engl J Med 340:115-126 (Pubitemid 29054847)
2. Glass CK, Witztum JL 2001 Atherosclerosis: the road ahead. Cell 104:503-516 (Pubitemid 32201946)
3. Millatt LJ, Bocher V, Fruchart JC, Staels B 2003 Liver X receptors and the control of cholesterol homeostasis: potential therapeutic targets for the treatment of atherosclerosis. Biochim Biophys Acta 1631:107-118 (Pubitemid 36287507)
4. Tontonoz P, Mangelsdorf DJ 2003 Liver X receptor signaling pathways in cardiovascular disease. Mol Endocrinol 17:985-993 (Pubitemid 36683707)
5. Joseph SB, McKilligin E, Pei L, Watson MA, Collins AR, Laffitte BA, Chen M, Noh G, Goodman J, Hagger GN, Tran J, Tippin TK, Wang X, Lusis AJ, Hsueh WA, Law RE, Collins JL, Willson TM, Tontonoz P 2002 Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci USA 99:7604-7609 (Pubitemid 34568738)
6. Bradley MN, Hong C, Chen M, Joseph SB, Wilpitz DC, Wang X, Lusis AJ, Collins A, Hseuh WA, Collins JL, Tangirala RK, Tontonoz P 2007 Ligand activation of LXRβ reverses atherosclerosis and cellular cholesterol overload in mice lacking LXRα and apoE. J Clin Invest 117:2337-2346 (Pubitemid 47219578)
7. Tangirala RK, Bischoff ED, Joseph SB, Wagner BL, Walczak R, Laffitte BA, Daige CL, Thomas D, Heyman RA, Mangelsdorf DJ, Wang X, Lusis AJ, Tontonoz P, Schulman IG 2002 Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc Natl Acad Sci USA 99:11896-11901 (Pubitemid 34994495)
8. Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schütz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P, Evans RM 1995 The nuclear receptor superfamily: the second decade. Cell 83:835-839 (Pubitemid 126663112)
9. McKenna NJ, Lanz RB, O'Malley BW 1999 Nuclear receptor coregulators: cellular and molecular biology. Endocr Rev 20:321-344 (Pubitemid 30649811)
10. Caira F, Antonson P, Pelto-Huikko M, Treuter E, Gustafsson JA 2000 Cloning and characterization of RAP250, a novel nuclear receptor coactivator. J Biol Chem 275:5308-5317 (Pubitemid 30115159)
11. Ko L, Cardona GR, Chin WW 2000 Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator. Proc Natl Acad Sci USA 97:6212-6217 (Pubitemid 30367549)
12. Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW 1999 A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. J Biol Chem 274:34283-34293 (Pubitemid 129511770)
13. Lee SK, Jung SY, Kim YS, Na SY, Lee YC, Lee JW 2001 Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2. Mol Endocrinol 15:241-254 (Pubitemid 32128705)
14. Lee SK, Na SY, Jung SY, Choi JE, Jhun BH, Cheong J, Meltzer PS, Lee YC, Lee JW 2000 Activating protein-1, nuclear factor-κB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2. Mol Endocrinol 14:915-925 (Pubitemid 32260503)
15. Mahajan MA, Samuels HH 2000 A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein. Mol Cell Biol 20:5048-5063 (Pubitemid 30431559)
16. Tanner MM, Tirkkonen M, Kallioniemi A, Isola J, Kuukasjärvi T, Collins C, Kowbel D, Guan XY, Trent J, Gray JW, Meltzer P, Kallioniemi OP 1996 Independent amplification and frequent co-amplification of three nonsyntenic regions on the long arm of chromosome 20 in human breast cancer. Cancer Res 56:3441-3445 (Pubitemid 26251634)
17. Zhu Y, Kan L, Qi C, Kanwar YS, Yeldandi AV, Rao MS, Reddy JK 2000 Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR. J Biol Chem 275:13510-13516 (Pubitemid 30257416)
18. Choi E, Lee S, Yeom SY, Kim GH, Lee JW, Kim SW 2005 Characterization of activating signal cointegrator-2 as a novel transcriptional coactivator of the xenobiotic nuclear receptor constitutive androstane receptor. Mol Endocrinol 19:1711-1719 (Pubitemid 41007885)
19. Kim SW, Cheong C, Sohn YC, Goo YH, Oh WJ, Park JH, Joe SY, Kang HS, Kim DK, Kee C, Lee JW, Lee HW 2002 Multiple developmental defects derived from impaired recruitment of ASC-2 to nuclear receptors in mice: implication for posterior lenticonus with cataract. Mol Cell Biol 22:8409-8414 (Pubitemid 35397157)
20. Kim SW, Park K, Kwak E, Choi E, Lee S, Ham J, Kang H, Kim JM, Hwang SY, Kong YY, Lee K, Lee JW 2003 Activating signal cointegrator 2 required for liver lipid metabolism mediated by liver X receptors in mice. Mol Cell Biol 23:3583-3592 (Pubitemid 36539191)
21. Yeom SY, Kim GH, Kim CH, Jung HD, Kim SY, Park JY, Pak YK, Rhee DK, Kuang SQ, Xu J, Han DJ, Song DK, Lee JW, Lee KU, Kim SW 2006 Regulation of insulin secretion and β-cell mass by activating signal cointegrator 2. Mol Cell Biol 26:4553-4563 (Pubitemid 43880325)
22. Zhang H, Liao L, Kuang SQ, Xu J 2003 Spatial distribution of the messenger ribonucleic acid and protein of the nuclear receptor coactivator, amplified in breast cancer-3, in mice. Endocrinology 144:1435-1443 (Pubitemid 36428486)
23. Lee S, Lee J, Lee SK, Lee JW 2008 Activating signal cointegrator-2 is an essential adaptor to recruit histone H3 lysine 4 methyltransferases MLL3 and MLL4 to the liver X receptors. Mol Endocrinol 22:1312-1319 (Pubitemid 351786992)
24. Acevedo ML, Lee KC, Stender JD, Katzenellenbogen BS, Kraus WL 2004 Selective recognition of distinct classes of coactivators by a ligand-inducible activation domain. Mol Cell 13:725-738 (Pubitemid 38368129)
25. Mahajan MA, Samuels HH 2005 Nuclear hormone receptor coregulator: role in hormone action, metabolism, growth, and development. Endocr Rev 26:583-597 (Pubitemid 41014266)
26. Toresson G, Schuster GU, Steffensen KR, Bengtsson M, Ljunggren J, Dahlman-Wright K, Gustafsson JA 2004 Purification of functional full-length liver X receptor β produced in Escherichia coli. Protein Expr Purif 35:190-198
27. Li Q, Chu MJ, Xu J 2007 Tissue- and nuclear receptor-specific function of the C-terminal LXXLL motif of coactivator NCoA6/AIB3 in mice. Mol Cell Biol 27:8073-8086 (Pubitemid 350234224)
28. Langmann T, Klucken J, Reil M, Liebisch G, Luciani MF, Chimini G, Kaminski WE, Schmitz G 1999 Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): evidence for sterol-dependent regulation in macrophages. Biochem Biophys Res Commun 257:29-33 (Pubitemid 29299042)
29. Klucken J, Büchler C, Orsó E, Kaminski WE, Porsch-Ozcürümez M, Liebisch G, Kapinsky M, Diederich W, Drobnik W, Dean M, Allikmets R, Schmitz G 2000 ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport. Proc Natl Acad Sci USA 97:817-822
30. Bodzioch M, Orsó E, Klucken J, Langmann T, Böttcher A, Diederich W, Drobnik W, Barlage S, Büchler C, Porsch-Ozcürümez M, Kaminski WE, Hahmann HW, Oette K, Rothe G, Aslanidis C, Lackner KJ, Schmitz G 1999 The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. Nat Genet 22:347-351 (Pubitemid 29369524)
31. Brooks-Wilson A, Marcil M, Clee SM, Zhang LH, Roomp K, van Dam M, Yu L, Brewer C, Collins JA, Molhuizen HO, Loubser O, Ouelette BF, Fichter K, Ashbourne-Excoffon KJ, Sensen CW, Scherer S, Mott S, Denis M, Martindale D, Frohlich J, Morgan K, Koop B, Pimstone S, Kastelein JJ, Genest Jr J, Hayden MR 1999 Mutations in ABC1 in Tangier disease and familial highdensity lipoprotein deficiency. Nat Genet 22:336-345 (Pubitemid 29369523)
32. Rust S, Rosier M, Funke H, Real J, Amoura Z, Piette JC, Deleuze JF, Brewer HB, Duverger N, Denèfle P, Assmann G 1999 Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1. Nat Genet 22:352-355 (Pubitemid 29369525)
33. Wang X, Collins HL, Ranalletta M, Fuki IV, Billheimer JT, Rothblat GH, Tall AR, Rader DJ 2007 Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo. J Clin Invest 117:2216-2224 (Pubitemid 47219566)
34. Kinoshita M, Kawamura M, Maeda T, Fujimaki Y, Fujita M, Kojima K, Teramoto T 2000 Apolipoprotein E accelerates the efflux of cholesterol from macrophages: mechanism of xanthoma formation in apolipoprotein E deficiency. J Atheroscler Thromb 6:22-27
35. Linton MF, Atkinson JB, Fazio S 1995 Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation. Science 267:1034-1037
36. Kennedy MA, Venkateswaran A, Tarr PT, Xenarios I, Kudoh J, Shimizu N, Edwards PA 2001 Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein. J Biol Chem 276:39438-39447 (Pubitemid 37371322)
37. Laffitte BA, Repa JJ, Joseph SB, Wilpitz DC, Kast HR, Mangelsdorf DJ, Tontonoz P 2001 LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proc Natl Acad Sci USA 98:507-512 (Pubitemid 32105072)
38. Schwartz K, Lawn RM, Wade DP 2000 ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR. Biochem Biophys Res Commun 274:794-802 (Pubitemid 30663699)
39. Zhang Y, Liu C, Zhu L, Jiang X, Chen X, Qi X, Liang X, Jin S, Zhang P, Li Q, Wang D, Liu X, Zeng K, Zhang J, Xiang Y, Zhang CY 2007 PGC-1α inhibits oleic acid induced proliferation and migration of rat vascular smooth muscle cells. PLoS ONE 2:e1137 (Pubitemid 351597375)
40. Li HJ, Haque Z, Lu Q, Li L, Karas R, Mendelsohn M 2007 Steroid receptor coactivator 3 is a coactivator for myocardin, the regulator of smooth muscle transcription and differentiation. Proc Natl Acad Sci USA 104:4065-4070 (Pubitemid 47181579)
41. Kim HJ, Park KG, Yoo EK, Kim YH, Kim YN, Kim HS, Kim HT, Park JY, Lee KU, Jang WG, Kim JG, Kim BW, Lee IK 2007 Effects of PGC-1α on TNF-α-induced MCP-1 and VCAM-1 expression and NF-κB activation in human aortic smooth muscle and endothelial cells. Antioxid Redox Signal 9:301-307 (Pubitemid 46150964)
42. Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW 2003 Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins. Mol Cell Biol 23:140-149 (Pubitemid 36008508)
43. T method. Methods 25:402-408
44. Francis GA, Knopp RH, Oram JF 1995 Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier disease. J Clin Invest 96:78-87
45. Orlando V, Strutt H, Paro R 1997 Analysis of chromatin structure by in vivo formaldehyde cross-linking. Methods 11:205-214 (Pubitemid 27210226)
46. Tangirala RK, Rubin EM, Palinski W 1995 Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice. J Lipid Res 36:2320-2328