FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 50, 2011, Pages 20107-20112

  Calkin, Anna C ^a   Goult, Benjamin T ^b   Zhang, Li ^a   Fairall, Louise ^b   Hong, Cynthia ^a   Schwabe, John W R ^b   Tontonoz, Peter ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

E3 UBIQUITIN LIGASE IDOL; LIPOPROTEIN RECEPTOR; PHOSPHOLIPID; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME STABILITY; LIPID METABOLISM; LIPID TRANSPORT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN STRUCTURE; RING FINGER MOTIF; SITE DIRECTED MUTAGENESIS; UBIQUITINATION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; CELL MEMBRANE; CONSERVED SEQUENCE; HEK293 CELLS; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS; RECEPTORS, LIPOPROTEIN; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84055187648     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1111589108     Document Type: Article

References (19)

1. Brown MS, Goldstein JL (1986) A receptor-mediated pathway for cholesterol homeostasis. Science 232:34-47. (Pubitemid 16037973)
2. Tolleshaug H, Hobgood KK, Brown MS, Goldstein JL (1983) The LDL receptor locus in familial hypercholesterolemia: Multiple mutations disrupt transport and processing of a membrane receptor. Cell 32:941-951. (Pubitemid 13087939)
3. Hobbs HH, Russell DW, Brown MS, Goldstein JL (1990) The LDL receptor locus in familial hypercholesterolemia: Mutational analysis of a membrane protein. Annu Rev Genet 24:133-170. (Pubitemid 120011544)
4. Hua X, et al. (1993) SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc Natl Acad Sci USA 90:11603-11607. (Pubitemid 24008687)
5. Maxwell KN, Breslow JL (2004) Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype. Proc Natl Acad Sci USA 101:7100-7105. (Pubitemid 38596449)
6. Park SW, Moon YA, Horton JD (2004) Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver. J Biol Chem 279:50630-50638.
7. Abifadel M, et al. (2003) Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat Genet 34:154-156. (Pubitemid 36666925)
8. Zelcer N, Hong C, Boyadjian R, Tontonoz P (2009) LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science 325:100-104.
9. Pearson MA, Reczek D, Bretscher A, Karplus PA (2000) Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain. Cell 101:259-270.
10. Bornhauser BC, Johansson C, Lindholm D (2003) Functional activities and cellular localization of the ezrin, radixin, moesin (ERM) and RING zinc finger domains in MIR. FEBS Lett 553:195-199. (Pubitemid 37206350)
11. Scotti E, et al. (2011) Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists. Mol Cell Biol 31:1885-1893.
12. Di Paolo G, et al. (2002) Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin. Nature 420:85-89. (Pubitemid 35291444)
13. Calderwood DA, et al. (1999) The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation. J Biol Chem 274:28071-28074.
14. Wegener KL, et al. (2008) Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain. J Mol Biol 382:112-126.
15. Hong C, et al. (2010) The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2. J Biol Chem 285:19720-19726.
16. Anthis NJ, et al. (2009) The structure of an integrin/talin complex reveals the basis of inside-out signal transduction. EMBO J 28:3623-3632.
17. He G, et al. (2002) ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2. J Biol Chem 277:44044-44049. (Pubitemid 36157831)
18. Zhang L, et al. (2011) The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor. Genes Dev 25:1262-1274.
19. Weissglas-Volkov D, et al. (2011) The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans. J Clin Invest 121:3062-3071.