-
1
-
-
66349134748
-
Cholesterol feedback: From Schoenheimer's bottle to Scap's MELADL
-
Brown, M. S., and J. L. Goldstein. 2009. Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL. J Lipid Res. 50(Suppl): S15-S27.
-
(2009)
J Lipid Res.
, vol.50
, Issue.SUPPL.
-
-
Brown, M.S.1
Goldstein, J.L.2
-
2
-
-
0035936802
-
Atherosclerosis. The road ahead
-
Glass, C. K., and J. L. Witztum. 2001. Atherosclerosis. The road ahead. Cell. 104: 503-516.
-
(2001)
Cell
, vol.104
, pp. 503-516
-
-
Glass, C.K.1
Witztum, J.L.2
-
3
-
-
0037503924
-
Liver X receptor signaling pathways in cardiovascular disease
-
DOI 10.1210/me.2003-0061
-
Tontonoz, P., and D. J. Mangelsdorf. 2003. Liver X receptor signaling pathways in cardiovascular disease. Mol. Endocrinol. 17: 985-993. (Pubitemid 36683707)
-
(2003)
Molecular Endocrinology
, vol.17
, Issue.6
, pp. 985-993
-
-
Tontonoz, P.1
Mangelsdorf, D.J.2
-
4
-
-
0034623288
-
Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor
-
Costet, P., Y. Luo, N. Wang, and A. R. Tall. 2000. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J. Biol. Chem. 275: 28240-28245.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 28240-28245
-
-
Costet, P.1
Luo, Y.2
Wang, N.3
Tall, A.R.4
-
5
-
-
0035895202
-
LXRs control lipid-inducible expression of the apolipoprotein e gene in macrophages and adipocytes
-
Laffitte, B. A., J. J. Repa, S. B. Joseph, D. C. Wilpitz, H. R. Kast, D. J. Mangelsdorf, and P. Tontonoz. 2001. LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proc. Natl. Acad. Sci. USA. 98: 507-512.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 507-512
-
-
Laffitte, B.A.1
Repa, J.J.2
Joseph, S.B.3
Wilpitz, D.C.4
Kast, H.R.5
Mangelsdorf, D.J.6
Tontonoz, P.7
-
6
-
-
34250214537
-
Molecular regulation of macrophage reverse cholesterol transport
-
DOI 10.1097/HCO.0b013e3281ec5113, PII 0000157320070700000017
-
Wang, X., and D. J. Rader. 2007. Molecular regulation of macrophage reverse cholesterol transport. Curr. Opin. Cardiol. 22: 368-372. (Pubitemid 46897290)
-
(2007)
Current Opinion in Cardiology
, vol.22
, Issue.4
, pp. 368-372
-
-
Wang, X.1
Rader, D.J.2
-
7
-
-
0037188553
-
Synthetic LXR ligand inhibits the development of atherosclerosis in mice
-
Joseph, S. B., E. McKilligin, L. Pei, M. A. Watson, A. R. Collins, B. A. Laffitte, M. Chen, G. Noh, J. Goodman, G. N. Hagger, et al. 2002. Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc. Natl. Acad. Sci. USA. 99: 7604-7609.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 7604-7609
-
-
Joseph, S.B.1
McKilligin, E.2
Pei, L.3
Watson, M.A.4
Collins, A.R.5
Laffitte, B.A.6
Chen, M.7
Noh, G.8
Goodman, J.9
Hagger, G.N.10
-
8
-
-
11144230882
-
Macrophage liver X receptor is required for antiatherogenic activity of LXR agonists
-
DOI 10.1161/01.ATV.0000150044.84012.68
-
Levin, N., E. D. Bischoff, C. L. Daige, D. Thomas, C. T. Vu, R. A. Heyman, R. K. Tangirala, and I. G. Schulman. 2005. Macrophage liver X receptor is required for antiatherogenic activity of LXR agonists. Arterioscler. Thromb. Vasc. Biol. 25: 135-142. (Pubitemid 40054266)
-
(2005)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.25
, Issue.1
, pp. 135-142
-
-
Levin, N.1
Bischoff, E.D.2
Daige, C.L.3
Thomas, D.4
Vu, C.T.5
Heyman, R.A.6
Tangirala, R.K.7
Schulman, I.G.8
-
9
-
-
33644651160
-
Liver X receptors as integrators of metabolic and inflammatory signaling
-
DOI 10.1172/JCI27883
-
Zelcer, N., and P. Tontonoz. 2006. Liver X receptors as integrators of metabolic and inflammatory signaling. J. Clin. Invest. 116: 607-614. (Pubitemid 43326865)
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.3
, pp. 607-614
-
-
Zelcer, N.1
Tontonoz, P.2
-
10
-
-
30444447387
-
Different roles of liver X receptor alpha and beta in lipid metabolism: Effects of an alpha-selective and a dual agonist in mice deficient in each subtype
-
Lund, E. G., L. B. Peterson, A. D. Adams, M. H. Lam, C. A. Burton, J. Chin, Q. Guo, S. Huang, M. Latham, J. C. Lopez, et al. 2006. Different roles of liver X receptor alpha and beta in lipid metabolism: effects of an alpha-selective and a dual agonist in mice deficient in each subtype. Biochem. Pharmacol. 71: 453-463.
-
(2006)
Biochem. Pharmacol.
, vol.71
, pp. 453-463
-
-
Lund, E.G.1
Peterson, L.B.2
Adams, A.D.3
Lam, M.H.4
Burton, C.A.5
Chin, J.6
Guo, Q.7
Huang, S.8
Latham, M.9
Lopez, J.C.10
-
11
-
-
0013199471
-
Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha
-
Peet, D. J., S. D. Turley, W. Ma, B. A. Janowski, J-M. A. Lobaccaro, R. E. Hammer, and D. J. Mangelsdorf. 1998. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell. 93: 693-704.
-
(1998)
Cell
, vol.93
, pp. 693-704
-
-
Peet, D.J.1
Turley, S.D.2
Ma, W.3
Janowski, B.A.4
Lobaccaro, J.-M.A.5
Hammer, R.E.6
Mangelsdorf, D.J.7
-
12
-
-
33748951579
-
Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: Implications for therapeutic targeting
-
Quinet, E. M., D. A. Savio, A. R. Halpern, L. Chen, G. U. Schuster, J. A. Gustafsson, M. D. Basso, and P. Nambi. 2006. Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting. Mol. Pharmacol. 70: 1340-1349.
-
(2006)
Mol. Pharmacol.
, vol.70
, pp. 1340-1349
-
-
Quinet, E.M.1
Savio, D.A.2
Halpern, A.R.3
Chen, L.4
Schuster, G.U.5
Gustafsson, J.A.6
Basso, M.D.7
Nambi, P.8
-
13
-
-
0034669025
-
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta
-
Repa, J. J., G. Liang, J. Ou, Y. Bashmakov, J. M. Lobaccaro, I. Shimomura, B. Shan, M. S. Brown, J. L. Goldstein, and D. J. Mangelsdorf. 2000. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev. 14: 2819-2830.
-
(2000)
Genes Dev.
, vol.14
, pp. 2819-2830
-
-
Repa, J.J.1
Liang, G.2
Ou, J.3
Bashmakov, Y.4
Lobaccaro, J.M.5
Shimomura, I.6
Shan, B.7
Brown, M.S.8
Goldstein, J.L.9
Mangelsdorf, D.J.10
-
14
-
-
0034669171
-
Role of LXRs in control of lipogenesis
-
Schultz, J. R., H. Tu, A. Luk, J. J. Repa, J. C. Medina, L. Li, S. Schwendner, S. Wang, M. Thoolen, D. J. Mangelsdorf, et al. 2000. Role of LXRs in control of lipogenesis. Genes Dev. 14: 2831-2838.
-
(2000)
Genes Dev.
, vol.14
, pp. 2831-2838
-
-
Schultz, J.R.1
Tu, H.2
Luk, A.3
Repa, J.J.4
Medina, J.C.5
Li, L.6
Schwendner, S.7
Wang, S.8
Thoolen, M.9
Mangelsdorf, D.J.10
-
15
-
-
0038614979
-
Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8
-
DOI 10.1074/jbc.M301311200
-
Yu, L., J. York, K. von Bergmann, D. Lutjohann, J. C. Cohen, and H. H. Hobbs. 2003. Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8. J. Biol. Chem. 278: 15565-15570. (Pubitemid 36799664)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.18
, pp. 15565-15570
-
-
Yu, L.1
York, J.2
Von Bergmann, K.3
Lutjohann, D.4
Cohen, J.C.5
Hobbs, H.H.6
-
16
-
-
0034284918
-
Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers
-
Repa, J. J., S. D. Turley, J. A. Lobaccaro, J. Medina, L. Li, K. Lustig, B. Shan, R. A. Heyman, J. M. Dietschy, and D. J. Mangelsdorf. 2000. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science. 289: 1524-1529.
-
(2000)
Science
, vol.289
, pp. 1524-1529
-
-
Repa, J.J.1
Turley, S.D.2
Lobaccaro, J.A.3
Medina, J.4
Li, L.5
Lustig, K.6
Shan, B.7
Heyman, R.A.8
Dietschy, J.M.9
Mangelsdorf, D.J.10
-
17
-
-
0037183561
-
Accumulation of foam cells in liver X receptor-deficient mice
-
DOI 10.1161/01.CIR.0000026802.79202.96
-
Schuster, G. U., P. Parini, L. Wang, S. Alberti, K. R. Steffensen, G. K. Hansson, B. Angelin, and J. A. Gustafsson. 2002. Accumulation of foam cells in liver X receptor-deficient mice. Circulation. 106: 1147-1153. (Pubitemid 34970858)
-
(2002)
Circulation
, vol.106
, Issue.9
, pp. 1147-1153
-
-
Schuster, G.U.1
Parini, P.2
Wang, L.3
Alberti, S.4
Steffensen, K.R.5
Hansson, G.K.6
Angelin, B.7
Gustafsson, J.-A.8
-
18
-
-
25444501883
-
Synthetic LXR agonists increase LDL in CETP species
-
Groot, P. H., N. J. Pearce, J. W. Yates, C. Stocker, C. Sauermelch, C. P. Doe, R. N. Willette, A. Olzinski, T. Peters, D. d'Epagnier, et al. 2005. Synthetic LXR agonists increase LDL in CETP species. J. Lipid Res. 46: 2182-2191.
-
(2005)
J. Lipid Res.
, vol.46
, pp. 2182-2191
-
-
Groot, P.H.1
Pearce, N.J.2
Yates, J.W.3
Stocker, C.4
Sauermelch, C.5
Doe, C.P.6
Willette, R.N.7
Olzinski, A.8
Peters, T.9
D'Epagnier, D.10
-
19
-
-
34547652884
-
Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE
-
Bradley, M. N., C. Hong, M. Chen, S. B. Joseph, D. C. Wilpitz, X. Wang, A. J. Lusis, A. Collins, W. A. Hseuh, J. L. Collins, et al. 2007. Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE. J. Clin. Invest. 117: 2337-2346.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 2337-2346
-
-
Bradley, M.N.1
Hong, C.2
Chen, M.3
Joseph, S.B.4
Wilpitz, D.C.5
Wang, X.6
Lusis, A.J.7
Collins, A.8
Hseuh, W.A.9
Collins, J.L.10
-
20
-
-
0037015013
-
Identification of macrophage liver X receptors as inhibitors of atherosclerosis
-
Tangirala, R. K., E. D. Bischoff, S. B. Joseph, B. L. Wagner, R. Walczak, B. A. Laffitte, C. L. Daige, D. Thomas, R. A. Heyman, D. J. Mangelsdorf, et al. 2002. Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc. Natl. Acad. Sci. USA. 99: 11896-11901.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 11896-11901
-
-
Tangirala, R.K.1
Bischoff, E.D.2
Joseph, S.B.3
Wagner, B.L.4
Walczak, R.5
Laffitte, B.A.6
Daige, C.L.7
Thomas, D.8
Heyman, R.A.9
Mangelsdorf, D.J.10
-
21
-
-
0043133791
-
Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression
-
Wagner, B. L., A. F. Valledor, G. Shao, C. L. Daige, E. D. Bischoff, M. Petrowski, K. Jepsen, S. H. Baek, R. A. Heyman, M. G. Rosenfeld, et al. 2003. Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression. Mol. Cell. Biol. 23: 5780-5789.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 5780-5789
-
-
Wagner, B.L.1
Valledor, A.F.2
Shao, G.3
Daige, C.L.4
Bischoff, E.D.5
Petrowski, M.6
Jepsen, K.7
Baek, S.H.8
Heyman, R.A.9
Rosenfeld, M.G.10
-
22
-
-
0037432165
-
T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice
-
DOI 10.1016/S0014-5793(02)03578-0, PII S0014579302035780
-
Terasaka, N., A. Hiroshima, T. Koieyama, N. Ubukata, Y. Morikawa, D. Nakai, and T. Inaba. 2003. T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice. FEBS Lett. 536: 6-11. (Pubitemid 36206397)
-
(2003)
FEBS Letters
, vol.536
, Issue.1-3
, pp. 6-11
-
-
Terasaka, N.1
Hiroshima, A.2
Koieyama, T.3
Ubukata, N.4
Morikawa, Y.5
Nakai, D.6
Inaba, T.7
-
23
-
-
47949094965
-
Integration of metabolism and inflammation by lipid-activated nuclear receptors
-
Bensinger, S. J., and P. Tontonoz. 2008. Integration of metabolism and inflammation by lipid-activated nuclear receptors. Nature. 454: 470-477.
-
(2008)
Nature
, vol.454
, pp. 470-477
-
-
Bensinger, S.J.1
Tontonoz, P.2
-
24
-
-
55449096410
-
Effect of macrophage overexpression of murine liver X receptor-alpha (LXR-alpha) on atherosclerosis in LDL-receptor deficient mice
-
Teupser, D., D. Kretzschmar, C. Tennert, R. Burkhardt, W. Wilfert, D. Fengler, R. Naumann, A. E. Sippel, and J. Thiery. 2008. Effect of macrophage overexpression of murine liver X receptor-alpha (LXR-alpha) on atherosclerosis in LDL-receptor deficient mice. Arterioscler. Thromb. Vasc. Biol. 28: 2009-2015.
-
(2008)
Arterioscler. Thromb. Vasc. Biol.
, vol.28
, pp. 2009-2015
-
-
Teupser, D.1
Kretzschmar, D.2
Tennert, C.3
Burkhardt, R.4
Wilfert, W.5
Fengler, D.6
Naumann, R.7
Sippel, A.E.8
Thiery, J.9
-
25
-
-
0028862192
-
Quantitation of atherosclerosis in murine models: Correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice
-
Tangirala, R. K., E. M. Rubin, and W. Palinski. 1995. Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice. J. Lipid Res. 36: 2320-2328.
-
(1995)
J. Lipid Res.
, vol.36
, pp. 2320-2328
-
-
Tangirala, R.K.1
Rubin, E.M.2
Palinski, W.3
-
26
-
-
40749097733
-
Laminar shear stress regulates liver X receptor in vascular endothelial cells
-
Zhu, M., Y. Fu, Y. Hou, N. Wang, Y. Guan, C. Tang, J. Y. Shyy, and Y. Zhu. 2008. Laminar shear stress regulates liver X receptor in vascular endothelial cells. Arterioscler. Thromb. Vasc. Biol. 28: 527-533.
-
(2008)
Arterioscler. Thromb. Vasc. Biol.
, vol.28
, pp. 527-533
-
-
Zhu, M.1
Fu, Y.2
Hou, Y.3
Wang, N.4
Guan, Y.5
Tang, C.6
Shyy, J.Y.7
Zhu, Y.8
-
27
-
-
46149098344
-
LXR signaling couples sterol metabolism to proliferation in the acquired immune response
-
Bensinger, S. J., M. N. Bradley, S. B. Joseph, N. Zelcer, E. M. Janssen, M. A. Hausner, R. Shih, J. S. Parks, P. A. Edwards, B. D. Jamieson, et al. 2008. LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell. 134: 97-111.
-
(2008)
Cell
, vol.134
, pp. 97-111
-
-
Bensinger, S.J.1
Bradley, M.N.2
Joseph, S.B.3
Zelcer, N.4
Janssen, E.M.5
Hausner, M.A.6
Shih, R.7
Parks, J.S.8
Edwards, P.A.9
Jamieson, B.D.10
-
28
-
-
37249001797
-
Apolipoprotein E-deficient lipoproteins induce foam cell formation by downregulation of lysosomal hydrolases in macrophages
-
DOI 10.1194/jlr.M700217-JLR200
-
Wu, D., C. Sharan, H. Yang, J. S. Goodwin, L. Zhou, G. A. Grabowski, H. Du, and Z. Guo. 2007. Apolipoprotein E-deficient lipoproteins induce foam cell formation by downregulation of lysosomal hydrolases in macrophages. J. Lipid Res. 48: 2571-2578. (Pubitemid 350272841)
-
(2007)
Journal of Lipid Research
, vol.48
, Issue.12
, pp. 2571-2578
-
-
Wu, D.1
Sharan, C.2
Yang, H.3
Goodwin, J.S.4
Zhou, L.5
Grabowski, G.A.6
Du, H.7
Guo, Z.8
|