-
1
-
-
10344263931
-
Neuronal membrane cholesterol loss enhances amyloid peptide generation
-
Abad-Rodriguez J, Ledesma MD, Craessaerts K, Perga S, Medina M, Delacourte A, Dingwall C, De Strooper B, and Dotti CG (2004) Neuronal membrane cholesterol loss enhances amyloid peptide generation. J Cell Biol 167:953-960.
-
(2004)
J Cell Biol
, vol.167
, pp. 953-960
-
-
Abad-Rodriguez, J.1
Ledesma, M.D.2
Craessaerts, K.3
Perga, S.4
Medina, M.5
Delacourte, A.6
Dingwall, C.7
De Strooper, B.8
Dotti, C.G.9
-
2
-
-
4544255297
-
Differential expression of cholesterol hydroxylases in Alzheimer's disease
-
Brown J 3rd, Theisler C, Silberman S, Magnuson D, Gottardi-Littell N, Lee JM, Yager D, Crowley J, Sambamurti K, Rahman MM, et al. (2004) Differential expression of cholesterol hydroxylases in Alzheimer's disease. J Biol Chem 279: 34674-34681.
-
(2004)
J Biol Chem
, vol.279
, pp. 34674-34681
-
-
Brown 3rd, J.1
Theisler, C.2
Silberman, S.3
Magnuson, D.4
Gottardi-Littell, N.5
Lee, J.M.6
Yager, D.7
Crowley, J.8
Sambamurti, K.9
Rahman, M.M.10
-
3
-
-
33745880391
-
The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo
-
Burns MP, Vardanian L, Pajoohesh-Ganji A, Wang L, Cooper M, Harris DC, Duff K, and Rebeck GW (2006) The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo. J Neurochem 98:792-800.
-
(2006)
J Neurochem
, vol.98
, pp. 792-800
-
-
Burns, M.P.1
Vardanian, L.2
Pajoohesh-Ganji, A.3
Wang, L.4
Cooper, M.5
Harris, D.C.6
Duff, K.7
Rebeck, G.W.8
-
4
-
-
0029047410
-
Identification of a putative steroidogenic factor-I response element in the DAX-1 promoter
-
Burris TP, Guo W, Le T, and McCabe ER (1995) Identification of a putative steroidogenic factor-I response element in the DAX-1 promoter. Biochem Biophys Res Commun 214:576-581.
-
(1995)
Biochem Biophys Res Commun
, vol.214
, pp. 576-581
-
-
Burris, T.P.1
Guo, W.2
Le, T.3
McCabe, E.R.4
-
5
-
-
50949111281
-
Seladin-1/DHCR24 protects neuroblastoma cells against Aβ toxicity by increasing membrane cholesterol content
-
in press
-
Cecchi C, Rosati F, Pensalfini A, Formigli L, Nosi D, Liguri G, Dichiara F, Morello M, Danza G, Pieraccini G, et al. (2008) Seladin-1/DHCR24 protects neuroblastoma cells against Aβ toxicity by increasing membrane cholesterol content. J Cell Mol Med, in press.
-
(2008)
J Cell Mol Med
-
-
Cecchi, C.1
Rosati, F.2
Pensalfini, A.3
Formigli, L.4
Nosi, D.5
Liguri, G.6
Dichiara, F.7
Morello, M.8
Danza, G.9
Pieraccini, G.10
-
6
-
-
31444454174
-
The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo
-
Crameri A, Biondi E, Kuehnle K, Lütjohann D, Thelen KM, Perga S, Dotti CG, Nitsch RM, Ledesma MD, and Mohajeri MH (2006) The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo. EMBO J 25:432-443.
-
(2006)
EMBO J
, vol.25
, pp. 432-443
-
-
Crameri, A.1
Biondi, E.2
Kuehnle, K.3
Lütjohann, D.4
Thelen, K.M.5
Perga, S.6
Dotti, C.G.7
Nitsch, R.M.8
Ledesma, M.D.9
Mohajeri, M.H.10
-
7
-
-
0037421206
-
Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts
-
Ehehalt R, Keller P, Haass C, Thiele C, and Simons K (2003) Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts. J Cell Biol 160:113-123.
-
(2003)
J Cell Biol
, vol.160
, pp. 113-123
-
-
Ehehalt, R.1
Keller, P.2
Haass, C.3
Thiele, C.4
Simons, K.5
-
8
-
-
37249053783
-
Thematic review series: Skin lipids. The role of epidermal lipids in cutaneous permeability barrier homeostasis
-
Feingold KR (2007) Thematic review series: skin lipids. The role of epidermal lipids in cutaneous permeability barrier homeostasis. J Lipid Res 48:2531-2546.
-
(2007)
J Lipid Res
, vol.48
, pp. 2531-2546
-
-
Feingold, K.R.1
-
9
-
-
0032937469
-
Effects of apolipoprotein E genotype on blood lipid composition and membrane platelet fluidity in Alzheimer's disease
-
Fernandes MA, Proençogueira AJ, Oliveira LM, Santiago B, Santana I, and Oliveira CR (1999) Effects of apolipoprotein E genotype on blood lipid composition and membrane platelet fluidity in Alzheimer's disease. Biochim Biophys Acta 1454:89-96.
-
(1999)
Biochim Biophys Acta
, vol.1454
, pp. 89-96
-
-
Fernandes, M.A.1
Proençogueira, A.J.2
Oliveira, L.M.3
Santiago, B.4
Santana, I.5
Oliveira, C.R.6
-
10
-
-
0034307463
-
The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress
-
Greeve I, Hermans-Borgmeyer I, Brellinger C, Kasper D, Gomez-Isla T, Behl C, Levkau B, and Nitsch RM (2000) The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress. J Neurosci 20:7345-7352.
-
(2000)
J Neurosci
, vol.20
, pp. 7345-7352
-
-
Greeve, I.1
Hermans-Borgmeyer, I.2
Brellinger, C.3
Kasper, D.4
Gomez-Isla, T.5
Behl, C.6
Levkau, B.7
Nitsch, R.M.8
-
11
-
-
27844553841
-
Hepatic peroxisomal fatty acid beta-oxidation is regulated by liver X receptor alpha
-
Hu T, Foxworthy P, Siesky A, Ficorilli JV, Gao H, Li S, Christe M, Ryan T, Cao G, Eacho P, et al. (2005) Hepatic peroxisomal fatty acid beta-oxidation is regulated by liver X receptor alpha. Endocrinology 146:5380-5387.
-
(2005)
Endocrinology
, vol.146
, pp. 5380-5387
-
-
Hu, T.1
Foxworthy, P.2
Siesky, A.3
Ficorilli, J.V.4
Gao, H.5
Li, S.6
Christe, M.7
Ryan, T.8
Cao, G.9
Eacho, P.10
-
12
-
-
0037067996
-
Seladin-1 transcription is linked to neuronal degeneration in Alzheimer's disease
-
Iivonen S, Hiltunen M, Alafuzoff I, Mannermaa A, Kerokoski P, Puoliväli J, Salminen A, Helisalmi S, and Soininen H (2002) Seladin-1 transcription is linked to neuronal degeneration in Alzheimer's disease. Neuroscience 113:301-310.
-
(2002)
Neuroscience
, vol.113
, pp. 301-310
-
-
Iivonen, S.1
Hiltunen, M.2
Alafuzoff, I.3
Mannermaa, A.4
Kerokoski, P.5
Puoliväli, J.6
Salminen, A.7
Helisalmi, S.8
Soininen, H.9
-
13
-
-
0034638746
-
Statins and the risk of dementia
-
Jick H, Zornberg GL, Jick SS, Seshadri S, and Drachman DA (2000) Statins and the risk of dementia. Lancet 356:1627-1631.
-
(2000)
Lancet
, vol.356
, pp. 1627-1631
-
-
Jick, H.1
Zornberg, G.L.2
Jick, S.S.3
Seshadri, S.4
Drachman, D.A.5
-
14
-
-
0037969631
-
22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid β secretion
-
Koldamova RP, Lefterov IM, Ikonomovic MD, Skoko J, Lefterov PI, Isanski BA, DeKosky ST, and Lazo JS (2003) 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid β secretion. J Biol Chem 278:13244-13256.
-
(2003)
J Biol Chem
, vol.278
, pp. 13244-13256
-
-
Koldamova, R.P.1
Lefterov, I.M.2
Ikonomovic, M.D.3
Skoko, J.4
Lefterov, P.I.5
Isanski, B.A.6
DeKosky, S.T.7
Lazo, J.S.8
-
15
-
-
14244255485
-
The liver X receptor ligand T0901317 decreases amyloid β production in vitro and in a mouse model of Alzheimer's disease
-
Koldamova RP, Lefterov IM, Staufenbiel M, Wolfe D, Huang S, Glorioso JC, Walter M, Roth MG, and Lazo JS (2005) The liver X receptor ligand T0901317 decreases amyloid β production in vitro and in a mouse model of Alzheimer's disease. J Biol Chem 280:4079-4088.
-
(2005)
J Biol Chem
, vol.280
, pp. 4079-4088
-
-
Koldamova, R.P.1
Lefterov, I.M.2
Staufenbiel, M.3
Wolfe, D.4
Huang, S.5
Glorioso, J.C.6
Walter, M.7
Roth, M.G.8
Lazo, J.S.9
-
16
-
-
37849018203
-
Prosurvival effect of DHCR24/Seladin-1 in acute and chronic responses to oxidative stress
-
Kuehnle K, Crameri A, Kälin RE, Luciani P, Benvenuti S, Peri A, Ratti F, Rodolfo M, Kulic L, Heppner FL, et al. (2008) Prosurvival effect of DHCR24/Seladin-1 in acute and chronic responses to oxidative stress. Mol Cell Biol 28:539-550.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 539-550
-
-
Kuehnle, K.1
Crameri, A.2
Kälin, R.E.3
Luciani, P.4
Benvenuti, S.5
Peri, A.6
Ratti, F.7
Rodolfo, M.8
Kulic, L.9
Heppner, F.L.10
-
17
-
-
0032573572
-
Elevated low-density lipoprotein in Alzheimer's disease correlates with brain abeta 1-42 levels
-
Kuo YM, Emmerling MR, Bisgaier CL, Essenburg AD, Lampert HC, Drumm D, and Roher AE (1998) Elevated low-density lipoprotein in Alzheimer's disease correlates with brain abeta 1-42 levels. Biochem Biophys Res Commun 252:711-715.
-
(1998)
Biochem Biophys Res Commun
, vol.252
, pp. 711-715
-
-
Kuo, Y.M.1
Emmerling, M.R.2
Bisgaier, C.L.3
Essenburg, A.D.4
Lampert, H.C.5
Drumm, D.6
Roher, A.E.7
-
18
-
-
0346463111
-
Raft disorganization leads to reduced plasmin activity in Alzheimer's disease brains
-
Ledesma MD, Abad-Rodriguez J, Galvan C, Biondi E, Navarro P, Delacourte A, Dingwall C, and Dotti CG (2003) Raft disorganization leads to reduced plasmin activity in Alzheimer's disease brains. EMBO Rep 4:1190-1196.
-
(2003)
EMBO Rep
, vol.4
, pp. 1190-1196
-
-
Ledesma, M.D.1
Abad-Rodriguez, J.2
Galvan, C.3
Biondi, E.4
Navarro, P.5
Delacourte, A.6
Dingwall, C.7
Dotti, C.G.8
-
20
-
-
0345669752
-
Alzheimer's disease: The cholesterol connection
-
Puglielli L, Tanzi RE, and Kovacs DM (2003) Alzheimer's disease: the cholesterol connection. Nat Neurosci 6:345-351.
-
(2003)
Nat Neurosci
, vol.6
, pp. 345-351
-
-
Puglielli, L.1
Tanzi, R.E.2
Kovacs, D.M.3
-
21
-
-
33947610707
-
The LXR agonist T0901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease
-
Riddell DR, Zhou H, Comery TA, Kouranova E, Lo CF, Warwick HK, Ring RH, Kirksey Y, Aschmies S, Xu J, et al. (2007) The LXR agonist T0901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease. Mol Cell Neurosci 34:621-628.
-
(2007)
Mol Cell Neurosci
, vol.34
, pp. 621-628
-
-
Riddell, D.R.1
Zhou, H.2
Comery, T.A.3
Kouranova, E.4
Lo, C.F.5
Warwick, H.K.6
Ring, R.H.7
Kirksey, Y.8
Aschmies, S.9
Xu, J.10
-
22
-
-
14844311992
-
Prediction of Nuclear Hormone Receptor Response Elements
-
Sandelin A and Wasserman WW (2005) Prediction of Nuclear Hormone Receptor Response Elements. Mol Endocrinol 19:595-606.
-
(2005)
Mol Endocrinol
, vol.19
, pp. 595-606
-
-
Sandelin, A.1
Wasserman, W.W.2
-
23
-
-
11844269279
-
Ligand-dependent coactivation of the human bile acid receptor FXR by the peroxisome proliferator-activated receptor γ coactivator-1 α
-
Savkur RS, Thomas JS, Bramlett KS, Gao Y, Michael LF, and Burris TP (2005) Ligand-dependent coactivation of the human bile acid receptor FXR by the peroxisome proliferator-activated receptor γ coactivator-1 α. J Pharmacol Exp Ther 312:170-178.
-
(2005)
J Pharmacol Exp Ther
, vol.312
, pp. 170-178
-
-
Savkur, R.S.1
Thomas, J.S.2
Bramlett, K.S.3
Gao, Y.4
Michael, L.F.5
Burris, T.P.6
-
24
-
-
42949178186
-
Thematic review series: Skin lipids. Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology
-
Schmuth M, Jiang YJ, Dubrac S, Elias PM, and Feingold KR (2008) Thematic review series: skin lipids. Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology. J Lipid Res 49:499-509.
-
(2008)
J Lipid Res
, vol.49
, pp. 499-509
-
-
Schmuth, M.1
Jiang, Y.J.2
Dubrac, S.3
Elias, P.M.4
Feingold, K.R.5
-
25
-
-
0034304851
-
Lipid rafts and signal transduction
-
Simons K and Toomre D (2000) Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 1:31-39.
-
(2000)
Nat Rev Mol Cell Biol
, vol.1
, pp. 31-39
-
-
Simons, K.1
Toomre, D.2
-
26
-
-
14244264780
-
Regulation of carbohydrate metabolism by the farnesoid X receptor
-
Stayrook KR, Bramlett KS, Savkur RS, Ficorilli J, Cook T, Christe ME, Michael LF, and Burris TP (2005) Regulation of carbohydrate metabolism by the farnesoid X receptor. Endocrinology 146:984-991.
-
(2005)
Endocrinology
, vol.146
, pp. 984-991
-
-
Stayrook, K.R.1
Bramlett, K.S.2
Savkur, R.S.3
Ficorilli, J.4
Cook, T.5
Christe, M.E.6
Michael, L.F.7
Burris, T.P.8
-
27
-
-
38549100334
-
Regulation of human 3α-hydroxysteroid dehydrogenase (AKR1C4) expression by the liver X receptor α
-
Stayrook KR, Rogers PM, Savkur RS, Wang Y, Su C, Varga G, Bu X, Wei T, Nagpal S, Liu XS, et al. (2008) Regulation of human 3α-hydroxysteroid dehydrogenase (AKR1C4) expression by the liver X receptor α. Mol Pharmacol 73:607-612.
-
(2008)
Mol Pharmacol
, vol.73
, pp. 607-612
-
-
Stayrook, K.R.1
Rogers, P.M.2
Savkur, R.S.3
Wang, Y.4
Su, C.5
Varga, G.6
Bu, X.7
Wei, T.8
Nagpal, S.9
Liu, X.S.10
-
28
-
-
0042346382
-
Expression of liver X receptor target genes decreases cellular amyloid β peptide secretion
-
Sun Y, Yao J, Kim TW, and Tall AR (2003) Expression of liver X receptor target genes decreases cellular amyloid β peptide secretion. J Biol Chem 278:27688-27694.
-
(2003)
J Biol Chem
, vol.278
, pp. 27688-27694
-
-
Sun, Y.1
Yao, J.2
Kim, T.W.3
Tall, A.R.4
-
29
-
-
34247191518
-
Classification and predictive modeling of liver X receptor response elements
-
Varga G and Su C (2007) Classification and predictive modeling of liver X receptor response elements. Biodrugs 21:117-124.
-
(2007)
Biodrugs
, vol.21
, pp. 117-124
-
-
Varga, G.1
Su, C.2
-
30
-
-
0034741599
-
Mutations in the 3beta-ydroxysterol delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis
-
Waterham HR, Koster J, Romeijn GJ, Hennekam RC, Vreken P, Andersson HC, FitzPatrick DR, Kelley RI, and Wanders RJ (2001) Mutations in the 3beta-ydroxysterol delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis. Am J Hum Genet 69:685-694.
-
(2001)
Am J Hum Genet
, vol.69
, pp. 685-694
-
-
Waterham, H.R.1
Koster, J.2
Romeijn, G.J.3
Hennekam, R.C.4
Vreken, P.5
Andersson, H.C.6
FitzPatrick, D.R.7
Kelley, R.I.8
Wanders, R.J.9
-
31
-
-
85047684678
-
Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system
-
Whitney KD, Watson MA, Collins JL, Benson WG, Stone TM, Numerick MJ, Tippin TK, Wilson JG, Winegar DA, and Kliewer SA (2002) Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system. Mol Endocrinol 16:1378-1385.
-
(2002)
Mol Endocrinol
, vol.16
, pp. 1378-1385
-
-
Whitney, K.D.1
Watson, M.A.2
Collins, J.L.3
Benson, W.G.4
Stone, T.M.5
Numerick, M.J.6
Tippin, T.K.7
Wilson, J.G.8
Winegar, D.A.9
Kliewer, S.A.10
-
32
-
-
12444256363
-
Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling
-
Yoshikawa T, Ide T, Shimano H, Yahagi N, Amemiya-Kudo M, Matsuzaka T, Yatoh S, Kitamine T, Okazaki H, Tamura Y, et al. (2003) Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling. Mol Endocrinol 17:1240-1254.
-
(2003)
Mol Endocrinol
, vol.17
, pp. 1240-1254
-
-
Yoshikawa, T.1
Ide, T.2
Shimano, H.3
Yahagi, N.4
Amemiya-Kudo, M.5
Matsuzaka, T.6
Yatoh, S.7
Kitamine, T.8
Okazaki, H.9
Tamura, Y.10
-
33
-
-
34547531201
-
Attenuation of neuroinflammation and Alzheimer's disease pathology by liver X receptors
-
Zelcer N, Khanlou N, Clare R, Jiang Q, Reed-Geaghan EG, Landreth GE, Vinters HV, and Tontonoz P (2007) Attenuation of neuroinflammation and Alzheimer's disease pathology by liver X receptors. Proc Natl Acad Sci U S A 104:10601-10606.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 10601-10606
-
-
Zelcer, N.1
Khanlou, N.2
Clare, R.3
Jiang, Q.4
Reed-Geaghan, E.G.5
Landreth, G.E.6
Vinters, H.V.7
Tontonoz, P.8
-
34
-
-
33644651160
-
Liver X receptors as integrators of metabolic and inflammatory signaling
-
Zelcer N and Tontonoz P (2006) Liver X receptors as integrators of metabolic and inflammatory signaling. J Clin Investig 116:607-614.
-
(2006)
J Clin Investig
, vol.116
, pp. 607-614
-
-
Zelcer, N.1
Tontonoz, P.2
|