메뉴 건너뛰기




Volumn 117, Issue 2, 2014, Pages 205-215

Role of Akt in human malignant glioma: From oncogenesis to tumor aggressiveness

Author keywords

Akt; Human malignant glioma; Resistance to treatment

Indexed keywords

4 [2 (4 AMINO 1,2,5 OXADIAZOL 3 YL) 1 ETHYL 7 (3 PIPERIDINYLMETHOXY) 1H IMIDAZO[4,5 C]PYRIDIN 4 YL] 2 METHYL 3 BUTYN 2 OL; 8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; BEVACIZUMAB; CYCLIC AMP DEPENDENT PROTEIN KINASE; ENZASTAURIN; EVEROLIMUS; GEFITINIB; HEAT SHOCK PROTEIN 90; IPATASERTIB; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; NELFINAVIR; PERIFOSINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE B; PROTEIN KINASE B BETA; PROTEIN KINASE C; PROTEIN MDM2; RHEB PROTEIN; SPHINGOSINE KINASE 1; TEMOZOLOMIDE; TEMSIROLIMUS; TUBERIN; ISOENZYME;

EID: 84901610670     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-014-1382-9     Document Type: Review
Times cited : (53)

References (113)
  • 1
    • 14244265590 scopus 로고    scopus 로고
    • Epidemiology and etiology of gliomas
    • 15685439
    • Ohgaki H, Kleihues P (2005) Epidemiology and etiology of gliomas. Acta Neuropathol 109:93-108
    • (2005) Acta Neuropathol , vol.109 , pp. 93-108
    • Ohgaki, H.1    Kleihues, P.2
  • 2
    • 0033581097 scopus 로고    scopus 로고
    • Cancer surveillance series [corrected]: Brain and other central nervous system cancers: Recent trends in incidence and mortality
    • 10451443
    • Legler JM, Ries LA, Smith MA, Warren JL, Heineman EF, Kaplan RS, Linet MS (1999) Cancer surveillance series [corrected]: brain and other central nervous system cancers: recent trends in incidence and mortality. J Natl Cancer Inst 91:1382-1390
    • (1999) J Natl Cancer Inst , vol.91 , pp. 1382-1390
    • Legler, J.M.1    Ries, L.A.2    Smith, M.A.3    Warren, J.L.4    Heineman, E.F.5    Kaplan, R.S.6    Linet, M.S.7
  • 4
    • 84874091180 scopus 로고    scopus 로고
    • The definition of primary and secondary glioblastoma
    • 23209033
    • Ohgaki H, Kleihues P (2013) The definition of primary and secondary glioblastoma. Clin Cancer Res 19:764-772
    • (2013) Clin Cancer Res , vol.19 , pp. 764-772
    • Ohgaki, H.1    Kleihues, P.2
  • 7
    • 47949131646 scopus 로고    scopus 로고
    • Antiangiogenics and radiotherapy
    • 18644195
    • Shannon AM, Williams KJ (2008) Antiangiogenics and radiotherapy. J Pharm Pharmacol 60:1029-1036
    • (2008) J Pharm Pharmacol , vol.60 , pp. 1029-1036
    • Shannon, A.M.1    Williams, K.J.2
  • 8
    • 0038523737 scopus 로고    scopus 로고
    • Tumor hypoxia at the micro-regional level: Clinical relevance and predictive value of exogenous and endogenous hypoxic cell markers
    • 12758235
    • Bussink J, Kaanders JH, van der Kogel AJ (2003) Tumor hypoxia at the micro-regional level: clinical relevance and predictive value of exogenous and endogenous hypoxic cell markers. Radiother Oncol 67:3-15
    • (2003) Radiother Oncol , vol.67 , pp. 3-15
    • Bussink, J.1    Kaanders, J.H.2    Van Der Kogel, A.J.3
  • 11
    • 0026006501 scopus 로고
    • Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families
    • 1718748
    • Coffer PJ, Woodgett JR (1991) Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. Eur J Biochem 201:475-481
    • (1991) Eur J Biochem , vol.201 , pp. 475-481
    • Coffer, P.J.1    Woodgett, J.R.2
  • 12
    • 0025882091 scopus 로고
    • Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily
    • 51620 1851997
    • Jones PF, Jakubowicz T, Pitossi FJ, Maurer F, Hemmings BA (1991) Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. Proc Natl Acad Sci USA 88:4171-4175
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 4171-4175
    • Jones, P.F.1    Jakubowicz, T.2    Pitossi, F.J.3    Maurer, F.4    Hemmings, B.A.5
  • 13
    • 0026095665 scopus 로고
    • A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
    • 1833819
    • Bellacosa A, Testa JR, Staal SP, Tsichlis PN (1991) A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science 254:274-277
    • (1991) Science , vol.254 , pp. 274-277
    • Bellacosa, A.1    Testa, J.R.2    Staal, S.P.3    Tsichlis, P.N.4
  • 15
    • 54949109808 scopus 로고    scopus 로고
    • PI3K/Akt: Getting it right matters
    • 18955974
    • Franke TF (2008) PI3K/Akt: getting it right matters. Oncogene 27:6473-6488
    • (2008) Oncogene , vol.27 , pp. 6473-6488
    • Franke, T.F.1
  • 16
    • 78649712949 scopus 로고    scopus 로고
    • MTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
    • 3020639 21045808
    • Oh WJ, Wu CC, Kim SJ, Facchinetti V, Julien LA, Finlan M, Roux PP, Su B, Jacinto E (2010) mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J 29:3939-3951
    • (2010) EMBO J , vol.29 , pp. 3939-3951
    • Oh, W.J.1    Wu, C.C.2    Kim, S.J.3    Facchinetti, V.4    Julien, L.A.5    Finlan, M.6    Roux, P.P.7    Su, B.8    Jacinto, E.9
  • 18
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • 15718470
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307:1098-1101
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 19
    • 4644359805 scopus 로고    scopus 로고
    • Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase
    • 15262962
    • Feng J, Park J, Cron P, Hess D, Hemmings BA (2004) Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase. J Biol Chem 279:41189-41196
    • (2004) J Biol Chem , vol.279 , pp. 41189-41196
    • Feng, J.1    Park, J.2    Cron, P.3    Hess, D.4    Hemmings, B.A.5
  • 20
    • 60549096247 scopus 로고    scopus 로고
    • Akt-dependent and -independent mechanisms of mTOR regulation in cancer
    • 2650010 19166931
    • Memmott RM, Dennis PA (2009) Akt-dependent and -independent mechanisms of mTOR regulation in cancer. Cell Signal 21:656-664
    • (2009) Cell Signal , vol.21 , pp. 656-664
    • Memmott, R.M.1    Dennis, P.A.2
  • 21
    • 84862103119 scopus 로고    scopus 로고
    • PI3K-independent AKT activation in cancers: A treasure trove for novel therapeutics
    • 3358464 22307544
    • Mahajan K, Mahajan NP (2012) PI3K-independent AKT activation in cancers: a treasure trove for novel therapeutics. J Cell Physiol 227:3178-3184
    • (2012) J Cell Physiol , vol.227 , pp. 3178-3184
    • Mahajan, K.1    Mahajan, N.P.2
  • 22
    • 0033551070 scopus 로고    scopus 로고
    • New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
    • 33561 10200246
    • Cantley LC, Neel BG (1999) New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci USA 96:4240-4245
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 4240-4245
    • Cantley, L.C.1    Neel, B.G.2
  • 23
    • 80052275615 scopus 로고    scopus 로고
    • PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains
    • 3167518 21873248
    • Gao X, Lowry PR, Zhou X, Depry C, Wei Z, Wong GW, Zhang J (2011) PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains. Proc Natl Acad Sci USA 108:14509-14514
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 14509-14514
    • Gao, X.1    Lowry, P.R.2    Zhou, X.3    Depry, C.4    Wei, Z.5    Wong, G.W.6    Zhang, J.7
  • 24
    • 15944406764 scopus 로고    scopus 로고
    • PHLPP: A phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth
    • 15808505
    • Gao T, Furnari F, Newton AC (2005) PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell 18:13-24
    • (2005) Mol Cell , vol.18 , pp. 13-24
    • Gao, T.1    Furnari, F.2    Newton, A.C.3
  • 25
    • 84878431342 scopus 로고    scopus 로고
    • Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer
    • 23454242
    • Seshacharyulu P, Pandey P, Datta K, Batra SK (2013) Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer. Cancer Lett 335:9-18
    • (2013) Cancer Lett , vol.335 , pp. 9-18
    • Seshacharyulu, P.1    Pandey, P.2    Datta, K.3    Batra, S.K.4
  • 26
    • 33947203621 scopus 로고    scopus 로고
    • PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms
    • 17386267
    • Brognard J, Sierecki E, Gao T, Newton AC (2007) PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol Cell 25:917-931
    • (2007) Mol Cell , vol.25 , pp. 917-931
    • Brognard, J.1    Sierecki, E.2    Gao, T.3    Newton, A.C.4
  • 27
    • 84862931549 scopus 로고    scopus 로고
    • LY294002 enhances cytotoxicity of temozolomide in glioma by down-regulation of the PI3K/Akt pathway
    • 22086271
    • Chen L, Han L, Shi Z, Zhang K, Liu Y, Zheng Y, Jiang T, Pu P, Jiang C, Kang C (2012) LY294002 enhances cytotoxicity of temozolomide in glioma by down-regulation of the PI3K/Akt pathway. Mol Med Rep 5:575-579
    • (2012) Mol Med Rep , vol.5 , pp. 575-579
    • Chen, L.1    Han, L.2    Shi, Z.3    Zhang, K.4    Liu, Y.5    Zheng, Y.6    Jiang, T.7    Pu, P.8    Jiang, C.9    Kang, C.10
  • 28
    • 23944526062 scopus 로고    scopus 로고
    • Activation of AKT kinases in cancer: Implications for therapeutic targeting
    • 16095999
    • Bellacosa A, Kumar CC, Di Cristofano A, Testa JR (2005) Activation of AKT kinases in cancer: implications for therapeutic targeting. Adv Cancer Res 94:29-86
    • (2005) Adv Cancer Res , vol.94 , pp. 29-86
    • Bellacosa, A.1    Kumar, C.C.2    Di Cristofano, A.3    Testa, J.R.4
  • 30
    • 0001457668 scopus 로고    scopus 로고
    • Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
    • 39663 8622988
    • Cheng JQ, Ruggeri B, Klein WM, Sonoda G, Altomare DA, Watson DK, Testa JR (1996) Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. Proc Natl Acad Sci USA 93:3636-3641
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 3636-3641
    • Cheng, J.Q.1    Ruggeri, B.2    Klein, W.M.3    Sonoda, G.4    Altomare, D.A.5    Watson, D.K.6    Testa, J.R.7
  • 31
    • 0030860466 scopus 로고    scopus 로고
    • Transforming activity and mitosis-related expression of the AKT2 oncogene: Evidence suggesting a link between cell cycle regulation and oncogenesis
    • 9190895
    • Cheng JQ, Altomare DA, Klein MA, Lee WC, Kruh GD, Lissy NA, Testa JR (1997) Transforming activity and mitosis-related expression of the AKT2 oncogene: evidence suggesting a link between cell cycle regulation and oncogenesis. Oncogene 14:2793-2801
    • (1997) Oncogene , vol.14 , pp. 2793-2801
    • Cheng, J.Q.1    Altomare, D.A.2    Klein, M.A.3    Lee, W.C.4    Kruh, G.D.5    Lissy, N.A.6    Testa, J.R.7
  • 32
    • 0001582482 scopus 로고
    • Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: Amplification of AKT1 in a primary human gastric adenocarcinoma
    • 305241 3037531
    • Staal SP (1987) Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. Proc Natl Acad Sci U S A 84:5034-5037
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 5034-5037
    • Staal, S.P.1
  • 33
    • 0033618371 scopus 로고    scopus 로고
    • Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines
    • 10419456
    • Nakatani K, Thompson DA, Barthel A, Sakaue H, Liu W, Weigel RJ, Roth RA (1999) Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines. J Biol Chem 274:21528-21532
    • (1999) J Biol Chem , vol.274 , pp. 21528-21532
    • Nakatani, K.1    Thompson, D.A.2    Barthel, A.3    Sakaue, H.4    Liu, W.5    Weigel, R.J.6    Roth, R.A.7
  • 36
    • 0032558822 scopus 로고    scopus 로고
    • Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC
    • 9799739
    • Haas-Kogan D, Shalev N, Wong M, Mills G, Yount G, Stokoe D (1998) Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. Curr Biol 8:1195-1198
    • (1998) Curr Biol , vol.8 , pp. 1195-1198
    • Haas-Kogan, D.1    Shalev, N.2    Wong, M.3    Mills, G.4    Yount, G.5    Stokoe, D.6
  • 37
    • 0025114687 scopus 로고
    • Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas
    • 55005 2236070
    • Sugawa N, Ekstrand AJ, James CD, Collins VP (1990) Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas. Proc Natl Acad Sci USA 87:8602-8606
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 8602-8606
    • Sugawa, N.1    Ekstrand, A.J.2    James, C.D.3    Collins, V.P.4
  • 39
  • 41
    • 77956288767 scopus 로고    scopus 로고
    • Loss of PTEN binding adapter protein NHERF1 from plasma membrane in glioblastoma contributes to PTEN inactivation
    • 2932801 20736378
    • Molina JR, Morales FC, Hayashi Y, Aldape KD, Georgescu MM (2010) Loss of PTEN binding adapter protein NHERF1 from plasma membrane in glioblastoma contributes to PTEN inactivation. Cancer Res 70:6697-6703
    • (2010) Cancer Res , vol.70 , pp. 6697-6703
    • Molina, J.R.1    Morales, F.C.2    Hayashi, Y.3    Aldape, K.D.4    Georgescu, M.M.5
  • 42
    • 3543056884 scopus 로고    scopus 로고
    • Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas
    • 15184909
    • Wang H, Zhang W, Huang HJ, Liao WS, Fuller GN (2004) Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas. Lab Invest 84:941-951
    • (2004) Lab Invest , vol.84 , pp. 941-951
    • Wang, H.1    Zhang, W.2    Huang, H.J.3    Liao, W.S.4    Fuller, G.N.5
  • 46
    • 0034020459 scopus 로고    scopus 로고
    • Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice
    • 10802656
    • Holland EC, Celestino J, Dai C, Schaefer L, Sawaya RE, Fuller GN (2000) Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice. Nat Genet 25:55-57
    • (2000) Nat Genet , vol.25 , pp. 55-57
    • Holland, E.C.1    Celestino, J.2    Dai, C.3    Schaefer, L.4    Sawaya, R.E.5    Fuller, G.N.6
  • 47
    • 0035884505 scopus 로고    scopus 로고
    • Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma
    • 11559533
    • Sonoda Y, Ozawa T, Aldape KD, Deen DF, Berger MS, Pieper RO (2001) Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma. Cancer Res 61:6674-6678
    • (2001) Cancer Res , vol.61 , pp. 6674-6678
    • Sonoda, Y.1    Ozawa, T.2    Aldape, K.D.3    Deen, D.F.4    Berger, M.S.5    Pieper, R.O.6
  • 49
    • 34548266099 scopus 로고    scopus 로고
    • AKT1, AKT2 and AKT3-dependent cell survival is cell line-specific and knockdown of all three isoforms selectively induces apoptosis in 20 human tumor cell lines
    • 17426444
    • Koseoglu S, Lu Z, Kumar C, Kirschmeier P, Zou J (2007) AKT1, AKT2 and AKT3-dependent cell survival is cell line-specific and knockdown of all three isoforms selectively induces apoptosis in 20 human tumor cell lines. Cancer Biol Ther 6:755-762
    • (2007) Cancer Biol Ther , vol.6 , pp. 755-762
    • Koseoglu, S.1    Lu, Z.2    Kumar, C.3    Kirschmeier, P.4    Zou, J.5
  • 50
    • 0036185848 scopus 로고    scopus 로고
    • The protein kinase B/Akt signalling pathway in human malignancy
    • 11882383
    • Nicholson KM, Anderson NG (2002) The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal 14:381-395
    • (2002) Cell Signal , vol.14 , pp. 381-395
    • Nicholson, K.M.1    Anderson, N.G.2
  • 51
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • 2756685 17604717
    • Manning BD, Cantley LC (2007) AKT/PKB signaling: navigating downstream. Cell 129:1261-1274
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 52
    • 0032484019 scopus 로고    scopus 로고
    • CREB is a regulatory target for the protein kinase Akt/PKB
    • 9829964
    • Du K, Montminy M (1998) CREB is a regulatory target for the protein kinase Akt/PKB. J Biol Chem 273:32377-32379
    • (1998) J Biol Chem , vol.273 , pp. 32377-32379
    • Du, K.1    Montminy, M.2
  • 53
    • 0033517189 scopus 로고    scopus 로고
    • NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase
    • 10485710
    • Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB (1999) NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401:82-85
    • (1999) Nature , vol.401 , pp. 82-85
    • Ozes, O.N.1    Mayo, L.D.2    Gustin, J.A.3    Pfeffer, S.R.4    Pfeffer, L.M.5    Donner, D.B.6
  • 54
    • 28044461715 scopus 로고    scopus 로고
    • Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma
    • 16275989
    • Koul D, Shen R, Bergh S, Lu Y, de Groot JF, Liu TJ, Mills GB, Yung WK (2005) Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma. Mol Cancer Ther 4:1681-1688
    • (2005) Mol Cancer Ther , vol.4 , pp. 1681-1688
    • Koul, D.1    Shen, R.2    Bergh, S.3    Lu, Y.4    De Groot, J.F.5    Liu, T.J.6    Mills, G.B.7    Yung, W.K.8
  • 55
    • 19944411156 scopus 로고    scopus 로고
    • Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth
    • 15782140
    • Edwards LA, Thiessen B, Dragowska WH, Daynard T, Bally MB, Dedhar S (2005) Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth. Oncogene 24:3596-3605
    • (2005) Oncogene , vol.24 , pp. 3596-3605
    • Edwards, L.A.1    Thiessen, B.2    Dragowska, W.H.3    Daynard, T.4    Bally, M.B.5    Dedhar, S.6
  • 57
    • 79956188245 scopus 로고    scopus 로고
    • Sphingosine kinase 1 regulates the Akt/FOXO3a/Bim pathway and contributes to apoptosis resistance in glioma cells
    • 3097221 21625639
    • Guan H, Song L, Cai J, Huang Y, Wu J, Yuan J, Li J, Li M (2011) Sphingosine kinase 1 regulates the Akt/FOXO3a/Bim pathway and contributes to apoptosis resistance in glioma cells. PLoS One 6:e19946
    • (2011) PLoS One , vol.6 , pp. 19946
    • Guan, H.1    Song, L.2    Cai, J.3    Huang, Y.4    Wu, J.5    Yuan, J.6    Li, J.7    Li, M.8
  • 58
    • 0035736487 scopus 로고    scopus 로고
    • HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
    • 11715018
    • Zhou BP, Liao Y, Xia W, Zou Y, Spohn B, Hung MC (2001) HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat Cell Biol 3:973-982
    • (2001) Nat Cell Biol , vol.3 , pp. 973-982
    • Zhou, B.P.1    Liao, Y.2    Xia, W.3    Zou, Y.4    Spohn, B.5    Hung, M.C.6
  • 60
    • 84875522870 scopus 로고    scopus 로고
    • Sorafenib selectively depletes human glioblastoma tumor-initiating cells from primary cultures
    • 3587450 23324350
    • Carra E, Barbieri F, Marubbi D, Pattarozzi A, Favoni RE, Florio T, Daga A (2013) Sorafenib selectively depletes human glioblastoma tumor-initiating cells from primary cultures. Cell Cycle 12:491-500
    • (2013) Cell Cycle , vol.12 , pp. 491-500
    • Carra, E.1    Barbieri, F.2    Marubbi, D.3    Pattarozzi, A.4    Favoni, R.E.5    Florio, T.6    Daga, A.7
  • 61
    • 34547114987 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol-3-OH kinase/Akt signaling impairs DNA repair in glioblastoma cells following ionizing radiation
    • 3614065 17513297
    • Kao GD, Jiang Z, Fernandes AM, Gupta AK, Maity A (2007) Inhibition of phosphatidylinositol-3-OH kinase/Akt signaling impairs DNA repair in glioblastoma cells following ionizing radiation. J Biol Chem 282:21206-21212
    • (2007) J Biol Chem , vol.282 , pp. 21206-21212
    • Kao, G.D.1    Jiang, Z.2    Fernandes, A.M.3    Gupta, A.K.4    Maity, A.5
  • 63
    • 84859856906 scopus 로고    scopus 로고
    • Gefitinib radiosensitizes stem-like glioma cells: Inhibition of epidermal growth factor receptor-Akt-DNA-PK signaling, accompanied by inhibition of DNA double-strand break repair
    • 22516386
    • Kang KB, Zhu C, Wong YL, Gao Q, Ty A, Wong MC (2012) Gefitinib radiosensitizes stem-like glioma cells: inhibition of epidermal growth factor receptor-Akt-DNA-PK signaling, accompanied by inhibition of DNA double-strand break repair. Int J Radiat Oncol Biol Phys 83:e43-e52
    • (2012) Int J Radiat Oncol Biol Phys , vol.83
    • Kang, K.B.1    Zhu, C.2    Wong, Y.L.3    Gao, Q.4    Ty, A.5    Wong, M.C.6
  • 64
    • 79960028514 scopus 로고    scopus 로고
    • MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks
    • 21623170
    • Fraser M, Harding SM, Zhao H, Coackley C, Durocher D, Bristow RG (2011) MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks. Cell Cycle 10:2218-2232
    • (2011) Cell Cycle , vol.10 , pp. 2218-2232
    • Fraser, M.1    Harding, S.M.2    Zhao, H.3    Coackley, C.4    Durocher, D.5    Bristow, R.G.6
  • 67
    • 84875459340 scopus 로고    scopus 로고
    • Proliferation-independent control of tumor glycolysis by PDGFR-mediated AKT activation
    • 23322009
    • Ran C, Liu H, Hitoshi Y, Israel MA (2013) Proliferation-independent control of tumor glycolysis by PDGFR-mediated AKT activation. Cancer Res 73:1831-1843
    • (2013) Cancer Res , vol.73 , pp. 1831-1843
    • Ran, C.1    Liu, H.2    Hitoshi, Y.3    Israel, M.A.4
  • 71
    • 0032730328 scopus 로고    scopus 로고
    • Opposite translational control of GLUT1 and GLUT4 glucose transporter mRNAs in response to insulin. Role of mammalian target of rapamycin, protein kinase b, and phosphatidylinositol 3-kinase in GLUT1 mRNA translation
    • 10551878
    • Taha C, Liu Z, Jin J, Al-Hasani H, Sonenberg N, Klip A (1999) Opposite translational control of GLUT1 and GLUT4 glucose transporter mRNAs in response to insulin. Role of mammalian target of rapamycin, protein kinase b, and phosphatidylinositol 3-kinase in GLUT1 mRNA translation. J Biol Chem 274:33085-33091
    • (1999) J Biol Chem , vol.274 , pp. 33085-33091
    • Taha, C.1    Liu, Z.2    Jin, J.3    Al-Hasani, H.4    Sonenberg, N.5    Klip, A.6
  • 72
    • 39049112846 scopus 로고    scopus 로고
    • AKT signaling in regulating angiogenesis
    • 18288940
    • Jiang BH, Liu LZ (2008) AKT signaling in regulating angiogenesis. Curr Cancer Drug Targets 8:19-26
    • (2008) Curr Cancer Drug Targets , vol.8 , pp. 19-26
    • Jiang, B.H.1    Liu, L.Z.2
  • 73
    • 33846199233 scopus 로고    scopus 로고
    • Hypoxia-inducible factors: Central regulators of the tumor phenotype
    • 3215290 17208433
    • Gordan JD, Simon MC (2007) Hypoxia-inducible factors: central regulators of the tumor phenotype. Curr Opin Genet Dev 17:71-77
    • (2007) Curr Opin Genet Dev , vol.17 , pp. 71-77
    • Gordan, J.D.1    Simon, M.C.2
  • 74
    • 0032765047 scopus 로고    scopus 로고
    • Studies of the molecular mechanisms in the regulation of telomerase activity
    • 10593857
    • Liu JP (1999) Studies of the molecular mechanisms in the regulation of telomerase activity. FASEB J 13:2091-2104
    • (1999) FASEB J , vol.13 , pp. 2091-2104
    • Liu, J.P.1
  • 75
    • 79955731315 scopus 로고    scopus 로고
    • Rictor regulates MMP-9 activity and invasion through Raf-1-MEK-ERK signaling pathway in glioma cells
    • 21557327
    • Das G, Shiras A, Shanmuganandam K, Shastry P (2011) Rictor regulates MMP-9 activity and invasion through Raf-1-MEK-ERK signaling pathway in glioma cells. Mol Carcinog 50:412-423
    • (2011) Mol Carcinog , vol.50 , pp. 412-423
    • Das, G.1    Shiras, A.2    Shanmuganandam, K.3    Shastry, P.4
  • 76
    • 49349113767 scopus 로고    scopus 로고
    • Runx2 is expressed in human glioma cells and mediates the expression of galectin-3
    • 18438928
    • Vladimirova V, Waha A, Luckerath K, Pesheva P, Probstmeier R (2008) Runx2 is expressed in human glioma cells and mediates the expression of galectin-3. J Neurosci Res 86:2450-2461
    • (2008) J Neurosci Res , vol.86 , pp. 2450-2461
    • Vladimirova, V.1    Waha, A.2    Luckerath, K.3    Pesheva, P.4    Probstmeier, R.5
  • 78
    • 0034642547 scopus 로고    scopus 로고
    • The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activity
    • 10644997
    • Morimoto AM, Tomlinson MG, Nakatani K, Bolen JB, Roth RA, Herbst R (2000) The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activity. Oncogene 19:200-209
    • (2000) Oncogene , vol.19 , pp. 200-209
    • Morimoto, A.M.1    Tomlinson, M.G.2    Nakatani, K.3    Bolen, J.B.4    Roth, R.A.5    Herbst, R.6
  • 79
    • 79958831578 scopus 로고    scopus 로고
    • Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model
    • 3118569 21507933
    • Endersby R, Zhu X, Hay N, Ellison DW, Baker SJ (2011) Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model. Cancer Res 71:4106-4116
    • (2011) Cancer Res , vol.71 , pp. 4106-4116
    • Endersby, R.1    Zhu, X.2    Hay, N.3    Ellison, D.W.4    Baker, S.J.5
  • 80
    • 0242499482 scopus 로고    scopus 로고
    • Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3′-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas
    • 14655756
    • Knobbe CB, Reifenberger G (2003) Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3′-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas. Brain Pathol 13:507-518
    • (2003) Brain Pathol , vol.13 , pp. 507-518
    • Knobbe, C.B.1    Reifenberger, G.2
  • 81
    • 9244227660 scopus 로고    scopus 로고
    • Antisense and dominant-negative AKT2 cDNA inhibits glioma cell invasion
    • 15557754
    • Pu P, Kang C, Li J, Jiang H (2004) Antisense and dominant-negative AKT2 cDNA inhibits glioma cell invasion. Tumour Biol 25:172-178
    • (2004) Tumour Biol , vol.25 , pp. 172-178
    • Pu, P.1    Kang, C.2    Li, J.3    Jiang, H.4
  • 82
    • 30944467414 scopus 로고    scopus 로고
    • The effects of antisense AKT2 RNA on the inhibition of malignant glioma cell growth in vitro and in vivo
    • 16402276
    • Pu P, Kang C, Li J, Jiang H, Cheng J (2006) The effects of antisense AKT2 RNA on the inhibition of malignant glioma cell growth in vitro and in vivo. J Neurooncol 76:1-11
    • (2006) J Neurooncol , vol.76 , pp. 1-11
    • Pu, P.1    Kang, C.2    Li, J.3    Jiang, H.4    Cheng, J.5
  • 83
    • 77953001932 scopus 로고    scopus 로고
    • AKT2 expression is associated with glioma malignant progression and required for cell survival and invasion
    • 20514445
    • Zhang J, Han L, Zhang A, Wang Y, Yue X, You Y, Pu P, Kang C (2010) AKT2 expression is associated with glioma malignant progression and required for cell survival and invasion. Oncol Rep 24:65-72
    • (2010) Oncol Rep , vol.24 , pp. 65-72
    • Zhang, J.1    Han, L.2    Zhang, A.3    Wang, Y.4    Yue, X.5    You, Y.6    Pu, P.7    Kang, C.8
  • 85
    • 84864742732 scopus 로고    scopus 로고
    • Knockdown of AKT2 expression by RNA interference inhibits proliferation, enhances apoptosis, and increases chemosensitivity to the anticancer drug VM-26 in U87 glioma cells
    • 22771706
    • Cui Y, Wang Q, Wang J, Dong Y, Luo C, Hu G, Lu Y (2012) Knockdown of AKT2 expression by RNA interference inhibits proliferation, enhances apoptosis, and increases chemosensitivity to the anticancer drug VM-26 in U87 glioma cells. Brain Res 1469:1-9
    • (2012) Brain Res , vol.1469 , pp. 1-9
    • Cui, Y.1    Wang, Q.2    Wang, J.3    Dong, Y.4    Luo, C.5    Hu, G.6    Lu, Y.7
  • 87
    • 77950050376 scopus 로고    scopus 로고
    • Increased expression of Akt2 and activity of PI3Kand cell proliferation with the ascending of tumor grade of human gliomas
    • 20116920
    • Wang G, Kang C, Pu P (2010) Increased expression of Akt2 and activity of PI3Kand cell proliferation with the ascending of tumor grade of human gliomas. Clin Neurol Neurosurg 112:324-327
    • (2010) Clin Neurol Neurosurg , vol.112 , pp. 324-327
    • Wang, G.1    Kang, C.2    Pu, P.3
  • 88
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455:1061-1068
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 92
    • 19644373959 scopus 로고    scopus 로고
    • Akt activation suppresses Chk2-mediated, methylating agent-induced G2 arrest and protects from temozolomide-induced mitotic catastrophe and cellular senescence
    • 15930307
    • Hirose Y, Katayama M, Mirzoeva OK, Berger MS, Pieper RO (2005) Akt activation suppresses Chk2-mediated, methylating agent-induced G2 arrest and protects from temozolomide-induced mitotic catastrophe and cellular senescence. Cancer Res 65:4861-4869
    • (2005) Cancer Res , vol.65 , pp. 4861-4869
    • Hirose, Y.1    Katayama, M.2    Mirzoeva, O.K.3    Berger, M.S.4    Pieper, R.O.5
  • 93
    • 23844457178 scopus 로고    scopus 로고
    • Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo
    • 16103096
    • Momota H, Nerio E, Holland EC (2005) Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo. Cancer Res 65:7429-7435
    • (2005) Cancer Res , vol.65 , pp. 7429-7435
    • Momota, H.1    Nerio, E.2    Holland, E.C.3
  • 95
    • 42249090359 scopus 로고    scopus 로고
    • Characterization of structurally distinct, isoform-selective phosphoinositide 3′-kinase inhibitors in combination with radiation in the treatment of glioblastoma
    • 18413797
    • Chen JS, Zhou LJ, Entin-Meer M, Yang X, Donker M, Knight ZA, Weiss W, Shokat KM, Haas-Kogan D, Stokoe D (2008) Characterization of structurally distinct, isoform-selective phosphoinositide 3′-kinase inhibitors in combination with radiation in the treatment of glioblastoma. Mol Cancer Ther 7:841-850
    • (2008) Mol Cancer Ther , vol.7 , pp. 841-850
    • Chen, J.S.1    Zhou, L.J.2    Entin-Meer, M.3    Yang, X.4    Donker, M.5    Knight, Z.A.6    Weiss, W.7    Shokat, K.M.8    Haas-Kogan, D.9    Stokoe, D.10
  • 101
    • 80052820448 scopus 로고    scopus 로고
    • North Central Cancer Treatment Group Phase i trial N057K of everolimus (RAD001) and temozolomide in combination with radiation therapy in patients with newly diagnosed glioblastoma multiforme
    • 3010479 20864273
    • Sarkaria JN, Galanis E, Wu W, Peller PJ, Giannini C, Brown PD, Uhm JH, McGraw S, Jaeckle KA, Buckner JC (2011) North Central Cancer Treatment Group Phase I trial N057K of everolimus (RAD001) and temozolomide in combination with radiation therapy in patients with newly diagnosed glioblastoma multiforme. Int J Radiat Oncol Biol Phys 81:468-475
    • (2011) Int J Radiat Oncol Biol Phys , vol.81 , pp. 468-475
    • Sarkaria, J.N.1    Galanis, E.2    Wu, W.3    Peller, P.J.4    Giannini, C.5    Brown, P.D.6    Uhm, J.H.7    McGraw, S.8    Jaeckle, K.A.9    Buckner, J.C.10
  • 102
    • 84876766342 scopus 로고    scopus 로고
    • Phase II study of bevacizumab and temsirolimus combination therapy for recurrent glioblastoma multiforme
    • 23564811
    • Lassen U, Sorensen M, Gaziel TB, Hasselbalch B, Poulsen HS (2013) Phase II study of bevacizumab and temsirolimus combination therapy for recurrent glioblastoma multiforme. Anticancer Res 33:1657-1660
    • (2013) Anticancer Res , vol.33 , pp. 1657-1660
    • Lassen, U.1    Sorensen, M.2    Gaziel, T.B.3    Hasselbalch, B.4    Poulsen, H.S.5
  • 103
    • 84880045561 scopus 로고    scopus 로고
    • RTOG 0913: A phase 1 study of daily everolimus (RAD001) in combination with radiation therapy and temozolomide in patients with newly diagnosed glioblastoma
    • 23725999
    • Chinnaiyan P, Won M, Wen PY, Rojiani AM, Wendland M, Dipetrillo TA, Corn BW, Mehta MP (2013) RTOG 0913: a phase 1 study of daily everolimus (RAD001) in combination with radiation therapy and temozolomide in patients with newly diagnosed glioblastoma. Int J Radiat Oncol Biol Phys 86:880-884
    • (2013) Int J Radiat Oncol Biol Phys , vol.86 , pp. 880-884
    • Chinnaiyan, P.1    Won, M.2    Wen, P.Y.3    Rojiani, A.M.4    Wendland, M.5    Dipetrillo, T.A.6    Corn, B.W.7    Mehta, M.P.8
  • 104
    • 67649958571 scopus 로고    scopus 로고
    • Current status and challenges associated with targeting mTOR for cancer therapy
    • 19489650
    • Dowling RJ, Pollak M, Sonenberg N (2009) Current status and challenges associated with targeting mTOR for cancer therapy. BioDrugs 23:77-91
    • (2009) BioDrugs , vol.23 , pp. 77-91
    • Dowling, R.J.1    Pollak, M.2    Sonenberg, N.3
  • 107
    • 77953452296 scopus 로고    scopus 로고
    • Biomarker development for the clinical activity of the mTOR inhibitor everolimus (RAD001): Processes, limitations, and further proposals
    • 2847314 20360931
    • O'Reilly T, McSheehy PM (2010) Biomarker development for the clinical activity of the mTOR inhibitor everolimus (RAD001): processes, limitations, and further proposals. Transl Oncol 3:65-79
    • (2010) Transl Oncol , vol.3 , pp. 65-79
    • O'Reilly, T.1    McSheehy, P.M.2
  • 108
    • 77958509195 scopus 로고    scopus 로고
    • Akt inhibitors in clinical development for the treatment of cancer
    • Pal SK, Reckamp K, Yu H, Figlin RA (2010) Akt inhibitors in clinical development for the treatment of cancer. Exp Opin Invest Drugs 19:1355-1366
    • (2010) Exp Opin Invest Drugs , vol.19 , pp. 1355-1366
    • Pal, S.K.1    Reckamp, K.2    Yu, H.3    Figlin, R.A.4
  • 113
    • 28844490209 scopus 로고    scopus 로고
    • A knotty turnabout? Akt1 as a metastasis suppressor
    • 16338656
    • Wyszomierski SL, Yu D (2005) A knotty turnabout? Akt1 as a metastasis suppressor. Cancer Cell 8:437-439
    • (2005) Cancer Cell , vol.8 , pp. 437-439
    • Wyszomierski, S.L.1    Yu, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.