Gefitinib radiosensitizes stem-like glioma cells: Inhibition of epidermal growth factor receptor-Akt-DNA-PK signaling, accompanied by inhibition of DNA double-strand break repair

International Journal of Radiation Oncology Biology Physics

Volumn 83, Issue 1, 2012, Pages

  Kang, Khong Bee ^a   Zhu, Congju ^a   Wong, Yin Ling ^a   Gao, Qiuhan ^a   Ty, Albert ^a   Wong, Meng Cheong ^a  

^a DIVISION OF MEDICAL ONCOLOGY   (Singapore)

Author keywords

Brain tumor stem cells; DNA PK; EGFR; Gefitinib; Radiotherapy

Indexed keywords

BRAIN TUMORS; CELL CYCLE; CLONOGENIC ASSAYS; CLONOGENIC SURVIVAL; DNA-PK; DOUBLE STRAND BREAK REPAIR; EGFR; EPIDERMAL GROWTH FACTOR RECEPTORS; EPIDERMAL GROWTH FACTORS; GEFITINIB; GLIOMA CELLS; IMMUNOSTAINING; NOD-SCID MICE; OLIGODENDROCYTES; PROTEIN KINASE;

ACTIVATION ANALYSIS; BRAIN; CYTOLOGY; IRRADIATION; MAMMALS; PHOSPHORYLATION; RADIATION; RADIOTHERAPY; REPAIR; STEM CELLS; TUMORS;

DNA;

DNA DEPENDENT PROTEIN KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; HISTONE H2AX; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; CANCER RADIOTHERAPY; CANCER TRANSPLANTATION; CARCINOGENICITY; CELL CYCLE ARREST; CELL CYCLE M PHASE; CELL DIFFERENTIATION; CELL SURVIVAL; CLONOGENIC ASSAY; CONTROLLED STUDY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; G2 PHASE CELL CYCLE CHECKPOINT; GLIOMA CELL; HUMAN; HUMAN CELL; MALE; MOUSE; NERVE CELL; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RADIOSENSITIZATION; SIGNAL TRANSDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS; BRAIN NEOPLASMS; DNA BREAKS, DOUBLE-STRANDED; DNA-ACTIVATED PROTEIN KINASE; GLIOMA; HISTONES; MICE; MICE, INBRED NOD; MICE, SCID; NEOPLASTIC STEM CELLS; NEUROGLIA; PHOSPHORYLATION; QUINAZOLINES; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; RECEPTOR, EPIDERMAL GROWTH FACTOR; TUMOR STEM CELL ASSAY;

EID: 84859856906     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2011.11.037     Document Type: Article

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