Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 31, 2007, Pages 12867-12872

  Huang, Paul H ^a   Mukasa, Akitake ^c   Bonavia, Rudy ^c   Flynn, Ryan A ^a   Brewer, Zachary E ^a   Cavenee, Webster K ^c,d   Furnari, Frank B ^c,d   White, Forest M ^a,b  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Mass spectrometry; Mutant EGF receptor; Signal transduction; Tyrosine phosphorylation

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; CISPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; EPIDERMAL GROWTH FACTOR VIII; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; PHA 665752; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTYROSINE; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; SCATTER FACTOR RECEPTOR; STAT3 PROTEIN; SU 11274; UNCLASSIFIED DRUG;

ARTICLE; CANCER CHEMOTHERAPY; CANCER RESISTANCE; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME INHIBITION; GLIOBLASTOMA; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; GLIOBLASTOMA; HUMANS; MICE; MICE, NUDE; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 34547881522     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0705158104     Document Type: Article

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