The chemokine CXCL12 and its receptor CXCR4 promote glioma stem cell-mediated VEGF production and tumour angiogenesis via PI3K/AKT signalling

Journal of Pathology

Volumn 224, Issue 3, 2011, Pages 344-354

  Ping, Yi Fang ^a   Yao, Xiao Hong ^a   Jiang, Jian Yong ^a   Zhao, Lin Tao ^a   Yu, Shi Cang ^a   Jiang, Tao ^b   Lin, Marie C M ^a,c   Chen, Jian Hong ^a   Wang, Bin ^a   Zhang, Rong ^a   Cui, You Hong ^a   Qian, Cheng ^a   Wang, Ji Ming ^d   Bian, Xiu Wu ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

angiogenesis; cancer stem cells; cell signalling; CXCR4; glioma

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PLERIXAFOR; PROTEIN KINASE B; STROMAL CELL DERIVED FACTOR 1; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CARCINOGENESIS; CELL ACTIVATION; CELL ISOLATION; CONTROLLED STUDY; GLIOMA; GLIOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; VASCULAR TUMOR;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD31; CELL TRANSFORMATION, NEOPLASTIC; CHEMOKINE CXCL12; GENE KNOCKDOWN TECHNIQUES; GLIOMA; GLYCOPROTEINS; HETEROCYCLIC COMPOUNDS; HUMANS; MICE; MICE, SCID; NEOPLASM PROTEINS; NEOPLASTIC STEM CELLS; NEOVASCULARIZATION, PATHOLOGIC; PEPTIDES; PHOSPHATIDYLINOSITOL 3-KINASES; RECEPTORS, CXCR4; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR STEM CELL ASSAY; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79958189212     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2908     Document Type: Article

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