Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth

Oncogene

Volumn 24, Issue 22, 2005, Pages 3596-3605

  Edwards, Lincoln A ^a,b,d   Thiessen, B ^a,b   Dragowska, Wieslawa H ^a   Daynard, Tim ^c   Bally, Marcel B ^a,b   Dedhar, Shoukat ^a,b  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c QLT Inc   (United States)

^d BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

Author keywords

Brain cancer; Glioblastomas; Integrin linked kinase

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; INTEGRIN LINKED KINASE; INTEGRIN LINKED KINASE ANTISENSE; OLIGONUCLEOTIDE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE ACTIVITY; GENE FUNCTION; GENE INACTIVATION; GENE TARGETING; GENETIC TRANSFECTION; GLIOBLASTOMA; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; PROMOTER REGION; PROSTATE CANCER; TUMOR GROWTH; TUMOR SUPPRESSOR GENE; TUMOR VOLUME; WILD TYPE;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BRAIN NEOPLASMS; CELL LINE, TUMOR; ENZYME ACTIVATION; FLOW CYTOMETRY; GLIOBLASTOMA; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MUTATION; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA;

EID: 19944411156     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1208427     Document Type: Article

References (39)

1. Cheney W, Neuteboom STC, Vaillancourt M-T, Ramachandra M and Bookstein R. (1999). Cancer Res., 59, 2318-2323.
2. Choe G, Horvath S, Cloughesy TF, Crosby K, Seligson D, Palotie A, Inge L, Smith BL, Sawyers CL and Mischel PS. (2003). Cancer Res., 63, 2742-2746.
3. Chung DH, Lee JI, Kook MC, Kim JR, Kim SH, Choi EY, Park SH and Song HG. (1998). Virchows Arch., 433, 113-117.
4. Cruet-Hennequart S, Maubant S, Luis J, Gauduchon P, Staedel C and Dedhar S. (2003). Oncogene, 22, 1688-1702.
5. D'Amico M, Hulit J, Amanatullah DF, Zafonte BT, Albanese C, Bouzahzah B, Fu M, Augenlicht LH, Donehower LA, Takemaru K, Moon RT, Davis R, Lisanti MP, Shtutman M, Zhurinsky J, Ben-Ze'ev A, Troussard AA, Dedhar S and Pestell RG. (2000). J. Biol. Chem., 275, 32649-32657.
6. Daumas-Duport C, Scheithauer BW, O'Fallon J and Kelly P. (1988). Cancer, 62, 2152-2165.
7. Delcommenne M, Tan C, Gray V, Rue L, Woodgett J and Dedhar S. (1998). Proc. Natl. Acad. Sci. USA, 95, 11211-11216.
8. Edwards L, Thiessen B, Yan H, Dedhar S and Bally M. (2003). Neuro-Oncology, 5, 300 (abstract).
9. Edwards LA, Shabbits J, Bally MB and Dedhar S. (2004). Integrin-linked Kinase (ILK) in Combination Molecular Targeting: Cancer Treatment and Research. Kluwer: New York.
10. Ermoian RP, Furniss CS, Lamborn KR, Basila D, Berger MS, Gottschalk AR, Nicholas MK, Stokoe D and Haas-Kogan DA. (2002). Clin. Cancer Res., 8, 1100-1106.
11. Graff JR, Deddens JA, Konicek BW, Colligan BM, Hurst BM, Carter HW and Carter JH. (2001). Clin. Cancer Res., 7, 1987-1991.
12. Haas-Koogan DA, Shaley N, Wong M, Mills G, Yount G and Stokoe D. (1998). Curr. Biol., 8, 1195-1198.
13. Hannigan GE, Leung-Hagesteijn C, Fitz-Gibbon L, Coppolino M, Radeva G, Filmus J, Bell JC and Dedhar S. (1996). Nature, 379, 91-96.
14. Hu Y, Cherton-Horvat G, Dragowska V, Baird S, Korneluk RG, Durkin JP, Mayer LD and LaCasse EC. (2003). Clin. Cancer Res., 9, 2826-2836.
15. Ishii T, Furuoka H, Muroi Y and Nishimura M. (2003). J. Biol. Chem., 278, 26970-26975.
16. Katso R, Okkenhaug K, Ahmadi K, White S, Timms J and Waterfield MD. (2001). Annu. Rev. Cell Dev. Biol., 17, 615-675.
17. Knobbe CB, Merlo A and Reifenberger G. (2002). Neuro-Oncology, 4, 196-211.
18. Li DM and Sun H. (1997). Cancer Res., 57, 2124-2129.
19. Li J, Yen C, Liaw D, Podyspaniana K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh B, Wigler MH and Parsons R. (1997). Science, 275, 1943-1947.
20. Liaw D, Marsh DJ, Li J, Dahia PL, Wang SI, Zheng Z, Bose S, Call KM, Tsou HC, Peacocke M, Eng C and Parsons R. (1997). Nat. Genet., 16, 64-67.
21. Marsh DJ, Roth S, Lunetta KL, Hemminki A, Dahia PL, Sistonen P, Zheng Z, Caron S, van Orsouw NJ, Bodmer WF, Cottrell SE, Dunlop MG, Eccles D, Hodgson SV, Jarvinen H, Kellokumpu I, Markie D, Neale K, Phillips R, Rozen P, Syngal S, Vijg J, Tomlinson IP, Aaltonen LA and Eng C. (1997). Cancer Res., 57, 5017-5021.
22. Nelen MR, van Staveren WC, Peeters EA, Kassel MB, Gorlin RJ, Hamm H, Lindboe CF, Fryns JP, Sijmons RH, Woods DG, Mariman EC, Padberg GW and Kremer H. (1997). Hum. Mol. Genet., 6, 1383-1387.
23. Novak A, Hsu SC, Leung-Hagesteijn C, Radeva G, Papkoff J, Montesano R, Roskelley C, Grosschedl R and Dedhar S. (1998). Proc. Natl. Acad. Sci. USA, 95, 4374-4379.
24. Obara S, Nakata M, Takeshima H, Katagiri H, Asano T, Oka Y, Maryuma I and Kuratsu J. (2004). Can. Lett., 208, 115-122.
25. Park M-J, Kim M-S, Park I-C, Kang H-S, Yoo H, Park S-H, Rhee CH, Hong S-I and Lee S-H. (2002). Can. Res., 62, 6318-6322.
26. Persad S, Attwell S, Gray V, Delecommenne M, Troussard A, Sanghera J and Dedhar S. (2000). Proc. Natl. Acad. Sci. USA, 97, 1322-1324.
27. Persad S, Attwell S, Gray V, Mawji N, Deng JT, Leung D, Van J, Sanghera J, Walsh MP and Dedhar S. (2001). J. Biol. Chem., 276, 27462-27469.
28. Pore N, Liu S, Haas-Kogan DA, O'Rourke DM and Maity A. (2003). Cancer Res., 63, 236-241.
29. Stambolic V, Suzuki A, de la Pompa JL, Brothers GM, Mirtsos C, Sasaki T, Ruland J, Penniger JM, Siderovski DP and Mak TW. (1998). Cell, 95, 29-39.
30. Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Thaylon D, Frye C, Hu R, Swedlund B, Teng DHR and Tavtigian SV. (1997). Nat. Genet., 15, 356-362.
31. Stolarov J, Chang K, Reiner A, Rodgers L, Hannon GJ, Wigler MH and Mittal V. (2001). Proc. Natl. Acad. Sci. USA, 98, 13043-13048.
32. Tan C, Cruet-Hennequart S, Troussard A, Fazli L, Costello P, Sutton K, Wheeler J, Gleave M, Sanghera J and Dedhar S. (2004). Cancer Cell., 5, 79-90.
33. Tan C, Mui A and Dedhar S. (2002). J. Biol. Chem., 277, 3109-3116.
34. Troussard AA, Costello P, Yoganathan TN, Kumagai S, Roskelley CD and Dedhar S. (2000). Oncogene, 19, 5444-5452.
35. Tsou HC, Teng DH, Fing XL, Brancolini V, Davis T, Hu R, Xie XX, Gruener AC, Schrager CA, Christiano AM, Eng C, Steck P, Ott J, Tavtigian SV and Peacocke M. (1997). Am. J. Hum. Genet., 61, 1036-1043.
36. Tu Y, Li F and Wu C. (1998). Mol. Biol. Cell, 9, 3367-3382.
37. Wang SI, Pue J, Li J, Bruce JN, Cairns P and Sidransky D. (1997). Cancer Res., 57, 4183-4186.
38. Waterhouse DN, Dragowska WH, Gelmon KA, Mayer LD and Bally MB. (2004). Can. Biol. Ther., 3, 197-204.
39. White DE, Cardiff RD, Dedhar S and Muller WJ. (2001). Oncogene, 20, 7064-7072.