Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells

Molecular Cancer Therapeutics

Volumn 8, Issue 2, 2009, Pages 386-393

  Gallia, Gary L ^a,d   Tyler, Betty M ^a   Hann, Christine L ^a   Siu, I Mei ^a   Giranda, Vincent L ^b   Vescovi, Angelo L ^c   Brem, Henry ^a   Riggins, Gregory J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ABBOTT LABORATORIES   (United States)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

^d JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; A 443654; A 739985; CASPASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; PHOSPHATIDYLINOSITOL 3 KINASE; POLY[1,3 BIS(CARBOXYPHENOXY)PROPANE CO SEBACIC ACID]; POLYMER; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER STEM CELL; CANCER SURVIVAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG SCREENING; DRUG SELECTIVITY; DRUG SENSITIVITY; ENZYME ASSAY; ENZYME INHIBITION; FEMALE; FLOW CYTOMETRY; GLIOBLASTOMA; GLIOBLASTOMA STEM LIKE CELL; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; TREATMENT RESPONSE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM; ENZYME ACTIVATION; FEMALE; GLIOBLASTOMA; HUMANS; INDAZOLES; INDOLES; MUTATION; NEOPLASTIC STEM CELLS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SURVIVAL ANALYSIS;

EID: 60849104091     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-08-0680     Document Type: Article

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